The University of Michigan Cancer Center Gl SPORE Administrative Core is reponsible for leadership, guidance, and management. The Administrative Core oversees all aspects and performs numerous duties across the expansive scope of the SPORE. These duties are to: 1. Provide scientific leadership, oversee scientific progress, ensures integration and asserts translational focus of all components of the Gl SPORE. 2. Provide logistical and coordinating support for all Gl SPORE operations;3. Manage and oversee the budgets of ail SPORE components;4. Administer developmental research projects and career development awards;5. Facilitate interactions between the Gl SPORE, other SPOREs, and the NCI;6. Communicate with NCI program staff and coordinate submission of required reports;7. Ensure recruitment of underserved minorities to all Gl SPORE projects and research support opportunities;8. Assure compliance with regulations regarding animals in research;9. Coordinate with the Biostatistics and Bioinformatics Core, the Cancer Center's Clinical Trials Office, and support Gl SPORE translational research in humans, and to ensure compliance Good Clinical Practice. Dean E. Brenner, M.D. will serve as prinicipal investigator of the Administrative Core. Dr. Brenner will oversee the day to day operations including all SPORE funcitons, budget, scientific and administrative decisions. He will serve as Chair of the SPORE Operations Committee and signs off on all Operations Committee decisions. Diane Simeone, M.D. will serve as co-principal investigator of the Administrative Core. A co-program director of the Cancer Center Gl Program, she serves as a critical link to the Gl Program. She will oversee the Career Development and Developmental Research Programs and she will oversee the use of SPORE discretionary funds. She will organize the joint SPORE and Gl Program retreats. Ms. Mary Rexer-Bluhm will serve as interim SPORE administrator until a permanent administrator is appointed. Ms. Rexer-Bluhm has provided administrative support for 10 SPORE submissions over the last 13 years for the University of Michigan Cancer Center and serves as the administrative supervisor for the SPORE Program Managers. This Core provides the frameworic to support the success and the mission of the UMCCC SPORE as a cohesive group of investigators committed to the development of translational research in Gl cancers.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Michigan Ann Arbor
Ann Arbor
United States
Zip Code
Dong, Liang; Zou, Hechang; Yuan, Chong et al. (2016) Different Fatty Acids Compete with Arachidonic Acid for Binding to the Allosteric or Catalytic Subunits of Cyclooxygenases to Regulate Prostanoid Synthesis. J Biol Chem 291:4069-78
Satagopan, Jaya M; Sen, Ananda; Zhou, Qin et al. (2016) Bayes and empirical Bayes methods for reduced rank regression models in matched case-control studies. Biometrics 72:584-95
Gifford, Gail B; Demitrack, Elise S; Keeley, Theresa M et al. (2016) Notch1 and Notch2 receptors regulate mouse and human gastric antral epithelial cell homoeostasis. Gut :
Umoh, Faith I; Kato, Ikuko; Ren, Jianwei et al. (2016) Markers of systemic exposures to products of intestinal bacteria in a dietary intervention study. Eur J Nutr 55:793-8
Parsels, Leslie A; Tanska, Daria M; Parsels, Joshua D et al. (2016) Dissociation of gemcitabine chemosensitization by CHK1 inhibition from cell cycle checkpoint abrogation and aberrant mitotic entry. Cell Cycle 15:730-9
Kirkconnell, Killeen S; Paulsen, Michelle T; Magnuson, Brian et al. (2016) Capturing the dynamic nascent transcriptome during acute cellular responses: The serum response. Biol Open 5:837-47
Ziemke, Elizabeth K; Dosch, Joseph S; Maust, Joel D et al. (2016) Sensitivity of KRAS-Mutant Colorectal Cancers to Combination Therapy That Cotargets MEK and CDK4/6. Clin Cancer Res 22:405-14
Sidahmed, ElKhansa; Sen, Ananda; Ren, Jianwei et al. (2016) Colonic Saturated Fatty Acid Concentrations and Expression of COX-1, but not Diet, Predict Prostaglandin E2 in Normal Human Colon Tissue. Nutr Cancer 68:1192-201
Dong, Liang; Zou, Hechang; Yuan, Chong et al. (2016) Interactions of 2-O-arachidonylglycerol ether and ibuprofen with the allosteric and catalytic subunits of human COX-2. J Lipid Res 57:1043-50
Zhang, Qiang; Zhang, Yaqing; Parsels, Joshua D et al. (2016) Fbxw7 Deletion Accelerates Kras(G12D)-Driven Pancreatic Tumorigenesis via Yap Accumulation. Neoplasia 18:666-673

Showing the most recent 10 out of 83 publications