Developmental Research Support for developmental research projects are a key SPORE element and are vital for fostering pioneering initiatives. As such, we will commit $140,000 annually to support three developmental research projects with budgets of approximately $45,000 each. The principal goal of the Developmental Research Program is to support innovative gastrointestinal cancer research with high translational impact, allowing investigators the ability to obtain key preliminary data for submission of an R01 application or an equivalent proposal (e.g., project in future SPORE application). Previously funded developmental research projects that have strong success during the initial funding period, but that have not obtained extramural funding, will be permitted to compete with new applications, with a maximum of two years of support possible. However, the expectation is that funds will support most projects for 1 year, with upwards of 15 new projects supported during the initial 5-year period of the grant. Projects will be solicited from University of Michigan Comprehensive Cancer Center (UMCCC) investigators and other University of Michigan faculty by campus-wide announcements and a standing advertisement for the Program at the UMCCC website listing other developmental research opportunities. Applications will utilize an NIH PHS398 format, with a 5-page limit on the body of the application (e.g., excluding references, detailed protocol information, appendix materials). Dr. Eric Fearon will serve as Director of the Developmental Research Program, and the UMCCC Cancer Research Committee (CRC) will undertake initial review, evaluating each proposal's scientific merit, innovation, gastrointestinal cancer relevance, and potential for translational impact. Given the CRC's expertise with rapid review of more than 100 pilot research proposals in laboratory, clinical, and population-based research annually, the CRC is well acquainted with review of projects with limited preliminary data. After review by the CRC, the Senior Advisory Group of the Gl SPORE will utilize assigned merit scores as a principal, but not sole, criterion in selection of proposals for support. Developmental research project investigators will take part in all Gl SPORE activities, and Dr. Fearon will meet quarterly with project Pis to offer in-depth review and mentorship.

Agency
National Institute of Health (NIH)
Type
Specialized Center (P50)
Project #
5P50CA130810-05
Application #
8729835
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Dong, Liang; Zou, Hechang; Yuan, Chong et al. (2016) Different Fatty Acids Compete with Arachidonic Acid for Binding to the Allosteric or Catalytic Subunits of Cyclooxygenases to Regulate Prostanoid Synthesis. J Biol Chem 291:4069-78
Satagopan, Jaya M; Sen, Ananda; Zhou, Qin et al. (2016) Bayes and empirical Bayes methods for reduced rank regression models in matched case-control studies. Biometrics 72:584-95
Gifford, Gail B; Demitrack, Elise S; Keeley, Theresa M et al. (2016) Notch1 and Notch2 receptors regulate mouse and human gastric antral epithelial cell homoeostasis. Gut :
Umoh, Faith I; Kato, Ikuko; Ren, Jianwei et al. (2016) Markers of systemic exposures to products of intestinal bacteria in a dietary intervention study. Eur J Nutr 55:793-8
Parsels, Leslie A; Tanska, Daria M; Parsels, Joshua D et al. (2016) Dissociation of gemcitabine chemosensitization by CHK1 inhibition from cell cycle checkpoint abrogation and aberrant mitotic entry. Cell Cycle 15:730-9
Kirkconnell, Killeen S; Paulsen, Michelle T; Magnuson, Brian et al. (2016) Capturing the dynamic nascent transcriptome during acute cellular responses: The serum response. Biol Open 5:837-47
Ziemke, Elizabeth K; Dosch, Joseph S; Maust, Joel D et al. (2016) Sensitivity of KRAS-Mutant Colorectal Cancers to Combination Therapy That Cotargets MEK and CDK4/6. Clin Cancer Res 22:405-14
Sidahmed, ElKhansa; Sen, Ananda; Ren, Jianwei et al. (2016) Colonic Saturated Fatty Acid Concentrations and Expression of COX-1, but not Diet, Predict Prostaglandin E2 in Normal Human Colon Tissue. Nutr Cancer 68:1192-201
Dong, Liang; Zou, Hechang; Yuan, Chong et al. (2016) Interactions of 2-O-arachidonylglycerol ether and ibuprofen with the allosteric and catalytic subunits of human COX-2. J Lipid Res 57:1043-50
Zhang, Qiang; Zhang, Yaqing; Parsels, Joshua D et al. (2016) Fbxw7 Deletion Accelerates Kras(G12D)-Driven Pancreatic Tumorigenesis via Yap Accumulation. Neoplasia 18:666-673

Showing the most recent 10 out of 83 publications