The principal role of the Administrative Core of the M. D. Anderson Cancer Center Prostate SPORE is to expand the integration of investigators from diverse scientific disciplines who have joined the translational research effort in prostate cancer. It is the purpose of the Administrative Core to provide continuous leadership and general administrative support for all SPORE-related activities. Dr. Christopher Logothetis, Director, and Dr. Timothy Thompson, Co-Director, provide support for all SPORE research projects, cores, and programs and ensure compliance with all governmental regulations, policies, and requirements. The Administrative Core coordinates data quality control and quality assurance in conjunction with the Biostatistics and Bioinformatics and Specimen Cores and the Internal and External Advisory Boards. The Administrative Core convenes all meetings of the SPORE, including seminars and lectures presented by scientific leaders in basic, translational, and clinical prostate cancer research brought to the SPORE by the Directors. With the Program Directors, the Administrative Core monitors the selection of projects and trainees for the Developmental Research and Career Development Programs, respectively. Dr. Logothetis chairs the Executive Committee, composed ofthe Co-Principal Investigator and senior scientific leaders with extensive SPORE experience. To address the ongoing needs of the minority and medically underserved communities in Houston and Harris County, Texas, Dr. Curtis Pettaway (Collaborator) has developed the Prostate Outreach Program integrated into SPORE research through the Administrative Core. Special Contributor Dr. Randall Millikan has developed the M. D. Anderson Prostate Research database (Research Repository) which serves the increasing data and bioinformatics needs of SPORE investigators, in collaboration with the Biostatistics and Bioinformatics and Specimen Cores. The Patient Advocacy program brings patient representation to the SPORE and increases awareness and education of prostate cancer research, treatment, and prevention in the community.

Public Health Relevance

The principal role of the Administrative Core of the M. D. Anderson Cancer Center Prostate SPORE is to expand the integration of investigators from diverse scientific disciplines who have joined the translational research effort in prostate cancer, and to provide continuous leadership and general administrative support for all SPORE-related activities.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA140388-05
Application #
8541603
Study Section
Special Emphasis Panel (ZCA1-RPRB-7)
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
5
Fiscal Year
2013
Total Cost
$236,194
Indirect Cost
$79,537
Name
University of Texas MD Anderson Cancer Center
Department
Type
DUNS #
800772139
City
Houston
State
TX
Country
United States
Zip Code
77030
Wang, Hong; Yang, Xu; Liu, Anna et al. (2018) ?-Tocopherol inhibits the development of prostate adenocarcinoma in prostate specific Pten-/- mice. Carcinogenesis 39:158-169
Velazquez-Torres, Guermarie; Shoshan, Einav; Ivan, Cristina et al. (2018) A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression. Nat Commun 9:461
Zanoaga, Oana; Jurj, Ancuta; Raduly, Lajos et al. (2018) Implications of dietary ?-3 and ?-6 polyunsaturated fatty acids in breast cancer. Exp Ther Med 15:1167-1176
Zhang, Wei; Liu, Bo; Wu, Wenhui et al. (2018) Targeting the MYCN-PARP-DNA Damage Response Pathway in Neuroendocrine Prostate Cancer. Clin Cancer Res 24:696-707
Monroig-Bosque, Paloma Del C; Shah, Maitri Y; Fu, Xiao et al. (2018) OncomiR-10b hijacks the small molecule inhibitor linifanib in human cancers. Sci Rep 8:13106
Basourakos, Spyridon P; Davis, John W; Chapin, Brian F et al. (2018) Baseline and longitudinal plasma caveolin-1 level as a biomarker in active surveillance for early-stage prostate cancer. BJU Int 121:69-76
Pan, Tianhong; Lin, Song-Chang; Yu, Kai-Jie et al. (2018) BIGH3 Promotes Osteolytic Lesions in Renal Cell Carcinoma Bone Metastasis by Inhibiting Osteoblast Differentiation. Neoplasia 20:32-43
Yu-Lee, Li-Yuan; Yu, Guoyu; Lee, Yu-Chen et al. (2018) Osteoblast-Secreted Factors Mediate Dormancy of Metastatic Prostate Cancer in the Bone via Activation of the TGF?RIII-p38MAPK-pS249/T252RB Pathway. Cancer Res 78:2911-2924
Luo, Yong; Azad, Abul Kalam; Karanika, Styliani et al. (2018) Enzalutamide and CXCR7 inhibitor combination treatment suppresses cell growth and angiogenic signaling in castration-resistant prostate cancer models. Int J Cancer 142:2163-2174
Soundararajan, Rama; Aparicio, Ana M; Logothetis, Christopher J et al. (2018) Function of Tumor Suppressors in Resistance to Antiandrogen Therapy and Luminal Epithelial Plasticity of Aggressive Variant Neuroendocrine Prostate Cancers. Front Oncol 8:69

Showing the most recent 10 out of 217 publications