The goal of the Career Development Program of the M. D. Anderson Cancer Center Prostate SPORE is to develop a cadre of investigators dedicated to translational studies in human prostate cancer. The program will (1) recruit innovative entry-level scientists into the Prostate SPORE to enhance its overall translational research capability and bring new techniques and talent to our SPORE program, (2) help these individuals develop the intellectual and technical skills required to be productive investigators in translational prostate cancer research, and (3) teach these individuals basic principles of cancer biology not commonly included in clinical training or PhD degree programs. The unique educational environment that exists at M. D. Anderson will ensure that these goals will be met. At least three Career Development awardees will be selected annually from qualified candidates within and outside M. D. Anderson Cancer Center. Awardees will be selected from the pool of candidates who respond to a SPORE solicitation based on objective criteria established by the Program Director and Co-Director in collaboration with the Principal Investigator and Co- Principal Investigator. Applications will be solicited and reviewed annually, and announcements for applications will be published in appropriate journals and on the SPORE web site as well as mailed to selected academic centers. The awardees'mentors have been selected from a large, diverse group of laboratory scientists and clinicians at M. D. Anderson based on their interest in translational science and skill as educators. The mentorship training will include principles of cancer biology, scientific methods, statistical analysis, biomedical communications, and strategies necessary to become successful in translational prostate cancer research. The program will be evaluated annually, and modifications in the selection process or training will be made when appropriate. Nine Career Development awards were funded by the initial SPORE in Prostate Cancer. Investigators receiving Career Development Awards reported 96 publications. A total of 25 externally reviewed grants were funded. Of note, one investigator (Dr. Jeri Kim) is a collaborator in Project 5 and the Specimen Core in this new M. D. Anderson Cancer Center Prostate SPORE proposal, reflecting the important role of the Career Development Program in identifying investigators with the potential to make significant contributions in translational prostate cancer research.

Public Health Relevance

The goal of the Career Development Program of the M. D. Anderson Cancer Center Prostate SPORE is to develop a cadre of investigators dedicated to translational studies in human prostate cancer by recruiting innovative entry-level scientists to enhance, the SPORE's overall translational research capability, helping these individuals develop intellectual and technical skills required to be productive investigators, and teaching these individuals basic principles of cancer biology.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA140388-05
Application #
8541607
Study Section
Special Emphasis Panel (ZCA1-RPRB-7)
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
5
Fiscal Year
2013
Total Cost
$132,862
Indirect Cost
$44,740
Name
University of Texas MD Anderson Cancer Center
Department
Type
DUNS #
800772139
City
Houston
State
TX
Country
United States
Zip Code
77030
Jin, J-K; Tien, P-C; Cheng, C-J et al. (2015) Talin1 phosphorylation activates ?1 integrins: a novel mechanism to promote prostate cancer bone metastasis. Oncogene 34:1811-21
Han, Ying; Signorello, Lisa B; Strom, Sara S et al. (2015) Generalizability of established prostate cancer risk variants in men of African ancestry. Int J Cancer 136:1210-7
Yu, Guoyu; Lee, Yu-Chen; Cheng, Chien-Jui et al. (2015) RSK promotes prostate cancer progression in bone through ING3, CKAP2, and PTK6-mediated cell survival. Mol Cancer Res 13:348-57
Al Olama, Ali Amin; Kote-Jarai, Zsofia; Berndt, Sonja I et al. (2014) A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer. Nat Genet 46:1103-9
Satcher, Robert L; Pan, Tianhong; Cheng, Chien-Jui et al. (2014) Cadherin-11 in renal cell carcinoma bone metastasis. PLoS One 9:e89880
Jiang, Xianhan; Li, Xun; Huang, Hai et al. (2014) Elevated levels of mitochondrion-associated autophagy inhibitor LRPPRC are associated with poor prognosis in patients with prostate cancer. Cancer 120:1228-36
Tien, Jean Ching-Yi; Liao, Lan; Liu, Yonghong et al. (2014) The steroid receptor coactivator-3 is required for developing neuroendocrine tumor in the mouse prostate. Int J Biol Sci 10:1116-27
Li, Likun; Chang, Wenjun; Yang, Guang et al. (2014) Targeting poly(ADP-ribose) polymerase and the c-Myb-regulated DNA damage response pathway in castration-resistant prostate cancer. Sci Signal 7:ra47
Li, Hongge; Tao, Chenqi; Cai, Zhigang et al. (2014) Frs2* and Shp2 signal independently of Gab to mediate FGF signaling in lens development. J Cell Sci 127:571-82
Lin, Zhuo-Yuan; Huang, Ya-Qiang; Zhang, Yan-Qiong et al. (2014) MicroRNA-224 inhibits progression of human prostate cancer by downregulating TRIB1. Int J Cancer 135:541-50

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