Abstract

To support the CIRNA projects and to provide a resource to the broader scientific community, the Biospecimen and Genotyping Core (BGC) will: (1) standardize the collection, processing, and storage of biospecimens from animal and human projects in the CIRNA;(2) implement a prospective system for tracking samples in the biospecimen repository and integrate these data with the current repository of -3,000 human specimens;and (3) for an exploratory genetic analysis, perform genotyping for polymorphisms hypothesized to contribute to abstinence symptoms or medication effects in Projects 3 and 4 (human studies). The BGC will also work with the Data Management and Biostatistics Core to integrate genotypic and phenotypic data, and to implement the CIRNA data sharing plan. The centralized sample processing and tracking strategy for all projects will increase efficiency and reduce the cost of undertaking the individual projects. All of these processes will occur within the context of extensive quality control procedures to ensure that the data provided to CIRNA investigators and to the scientific community are of the highest quality and accuracy.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA143187-04
Application #
8382187
Study Section
Special Emphasis Panel (ZDA1-RXL-E)
Project Start
Project End
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
4
Fiscal Year
2012
Total Cost
$97,699
Indirect Cost
$29,273

  Institution

Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Maurer, John J; Sandager-Nielsen, Karin; Schmidt, Heath D (2017) Attenuation of nicotine taking and seeking in rats by the stoichiometry-selective alpha4beta2 nicotinic acetylcholine receptor positive allosteric modulator NS9283. Psychopharmacology (Berl) 234:475-484
Perkins, Kenneth A; Karelitz, Joshua L; Michael, Valerie C et al. (2016) Initial Evaluation of Fenofibrate for Efficacy in Aiding Smoking Abstinence. Nicotine Tob Res 18:74-8
Schnoll, Robert A; Hitsman, Brian; Blazekovic, Sonja et al. (2016) Longitudinal changes in smoking abstinence symptoms and alternative reinforcers predict long-term smoking cessation outcomes. Drug Alcohol Depend 165:245-52
Ashare, Rebecca L; Lerman, Caryn; Cao, Wen et al. (2016) Nicotine withdrawal alters neural responses to psychosocial stress. Psychopharmacology (Berl) 233:2459-67
Falcone, Mary; Cao, Wen; Bernardo, Leah et al. (2016) Brain Responses to Smoking Cues Differ Based on Nicotine Metabolism Rate. Biol Psychiatry 80:190-7
Strasser, Andrew A; Souprountchouk, Valentina; Kaufmann, Amanda et al. (2016) Nicotine Replacement, Topography, and Smoking Phenotypes of E-cigarettes. Tob Regul Sci 2:352-362
Ashare, R L; Kimmey, B A; Rupprecht, L E et al. (2016) Repeated administration of an acetylcholinesterase inhibitor attenuates nicotine taking in rats and smoking behavior in human smokers. Transl Psychiatry 6:e713
Forcelli, Patrick A; Turner, Jill R; Lee, Bridgin G et al. (2016) Anxiolytic- and antidepressant-like effects of the methadone metabolite 2-ethyl-5-methyl-3,3-diphenyl-1-pyrroline (EMDP). Neuropharmacology 101:46-56
Cole, Robert D; Poole, Rachel L; Guzman, Dawn M et al. (2015) Contributions of ?2 subunit-containing nAChRs to chronic nicotine-induced alterations in cognitive flexibility in mice. Psychopharmacology (Berl) 232:1207-17
Yildirim, Emre; Connor, David A; Gould, Thomas J (2015) ABT-089, but not ABT-107, ameliorates nicotine withdrawal-induced cognitive deficits in C57BL6/J mice. Behav Pharmacol 26:241-8

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