A primary objective of the proposed center is to establish a laboratory for ongoing optimization of a comprehensive smoking cessation intervention. Our definition of intervention optimization is: "Employing scientific theory and efficient methodology to produce an evidence-based intervention that represents the maximal improvement in effectiveness, translatability and/or cost-effectiveness over currently available interventions." In the proposed center we plan to approach intervention optimization by using an innovative optimization cycle framework inspired by engineering methods. The optimization cycle is an extension and elaboration of the Multiphase Optimization Strategy (MOST), a phased experimental approach to intervention development and optimization developed by Collins, Murphy, Nair, and Strecher1 2. Potential advantages of using the, optimization cycle framework include: It is a systematic and principled approach, and therefore is the fastest way, in the long run, to an appreciably improved smoking cessation intervention;it provides a straightforward way of testing hypotheses about potential new intervention components or changes to existing components;it provides a natural way of including cost information in the basis for decision making about intervention development;and it will help contribute to the building of a coherent cumulative base of scientific knowledge about smoking cessation. The Intervention Optimization Core has four Specific Aims: (1) to serve as an intellectual resource to the center, providing ongoing input on the innovative optimization cycle framework and related statistical and methodological consultation as needed;(2) to conduct original methodological work to refine the optimization cycle approach, based on issues that arise in the course of the proposed optimization cycle;(3) to disseminate information about the optimization cycle approach to drug abuse prevention and treatment scientists, using the work of the proposed center as an illustration;and (4) to conduct exploratory analyses in preparation for a second optimization cycle, in collaboration with the Methods Core.

Public Health Relevance

The health, economic, and human costs of tobacco use are profound. The Intervention Optimization Core (IOC) is a critical component of the proposed center that will facilitate use of an innovative, efficient methodology for developing optimal smoking cessation interventions. The IOC will also advance intervention science by further studying this methodology so that it can be used by scientists in other fields.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center (P50)
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Special Emphasis Panel (ZDA1-RXL-E)
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University of Wisconsin Madison
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Baker, Timothy B; Gustafson, David H; Shah, Dhavan (2014) How can research keep up with eHealth? Ten strategies for increasing the timeliness and usefulness of eHealth research. J Med Internet Res 16:e36
Collins, Linda M; Dziak, John J; Kugler, Kari C et al. (2014) Factorial experiments: efficient tools for evaluation of intervention components. Am J Prev Med 47:498-504
Collins, Linda M; Nahum-Shani, Inbal; Almirall, Daniel (2014) Optimization of behavioral dynamic treatment regimens based on the sequential, multiple assignment, randomized trial (SMART). Clin Trials 11:426-434
Piper, Megan E; Baker, Timothy B; Mermelstein, Robin et al. (2013) Recruiting and engaging smokers in treatment in a primary care setting: developing a chronic care model implemented through a modified electronic health record. Transl Behav Med 3:253-63
Fiore, Michael C; Baker, Timothy B (2013) Should clinicians encourage smoking cessation for every patient who smokes? JAMA 309:1032-3
Collins, Linda M; MacKinnon, David P; Reeve, Bryce B (2013) Some methodological considerations in theory-based health behavior research. Health Psychol 32:586-91
Fraser, David; Christiansen, Bruce A; Adsit, Robert et al. (2013) Electronic health records as a tool for recruitment of participants' clinical effectiveness research: lessons learned from tobacco cessation. Transl Behav Med 3:244-52
Sims, Tammy H; McAfee, Timothy; Fraser, David L et al. (2013) Quitline cessation counseling for young adult smokers: a randomized clinical trial. Nicotine Tob Res 15:932-41
Coffman, Donna L; Kugler, Kari C (2012) Causal mediation of a human immunodeficiency virus preventive intervention. Nurs Res 61:224-30
Zhang, Xiao; Martinez-Donate, Ana P; Kuo, Daphne et al. (2012) Trends in home smoking bans in the U.S.A., 1995-2007: prevalence, discrepancies and disparities. Tob Control 21:330-6

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