The Center for Native Population Health Disparities is organized into an Administrative Core, a Training Core, and a Shared Resources Core, that includes both a Methods and Measurement Core and a Dissemination and Sustainability Core, and 5 Research Projects, Directorship ofthe Center will be shared by Dedra Buchwald, MD, Professor of Medicine and Director, Partnerships for Native Health, University of Washington, and Jeffrey Henderson (Cheyenne River Sioux), MD, MH, CEO of the non-profit, communitybased Black Hills Center for American Indian Health. Both investigators are nationally recognized for their research and leadership in areas directly relevant to all aspects of this RFA, as well as their ongoing efforts to understand and eliminate health disparities among American Indians and Alaska Native populations. Aligned with the """"""""team science"""""""" approach of this application, the Administrative Core integrates the University's strength in methods, training, and administration with the equally formidable strengths of the Black Hills Center for American Indian Health in community-based participatory research, field work, recruitment, and outreach with diverse Native populations. The Administrative Core will provide direction and support, both day-to-day and long-term, to each of the 5 Research Projects and other Cores. Accordingly, the specific aims ofthe Administrative Core are to: 1) Support the logistical and field operations of each Research Project and Core;2) Stimulate, coordinate, and monitor activities across Research Projects and Cores;3) Supervise implementation of key strategic decisions;and 4) Facilitate program planning and review. The Administrative Core staff will support a broad range of logistical operations, such as scheduling, communication, expenditures, monitoring, and human resources, across all Projects and Cores. An Executive Committee will make key strategic decisions and engage in program planning and review. The latter are conducted in concert with the National Institutes of Health program staff, and our Community Action Board, which is composed of local """"""""experts and stakeholders. Other key Administrative Core personnel at the University of Washington responsible for implementing the logistical tasks will be Janice Sabin, Ph.D., Department of Medical Education and Medical Bioinformatics;Kim Tran, B.A., Program Manager;and Michelle Xan, M.S., Senior Computer Specialist;and at the Black Hills Center for American Indian Health, Patricia Nez Henderson, MD, Vice President, and Sandra Albertson, BA, Director of Grants and Contracts, will assist Dr. Henderson.

Public Health Relevance

The challenges of working with Native communities are not trivial. Few institutions possess the infrastructure on which to build and sustain a program of research on Native health disparities. Stable, continuous, culturally attuned resources are necessary to successfully mount and sustain a program of research under these conditions, carrying it past the intermittent, unforeseen shortfalls in funding that often plague research projects. Our team has the commitment and resources to successfully carry out the work of this Center.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center (P50)
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Special Emphasis Panel (ZCA1-SRLB-3)
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University of Washington
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Tanner, Julie-Anne; Henderson, Jeffrey A; Buchwald, Dedra et al. (2017) Variation in CYP2A6 and nicotine metabolism among two American Indian tribal groups differing in smoking patterns and risk for tobacco-related cancer. Pharmacogenet Genomics 27:169-178
Engblom, Camilla; Pfirschke, Christina; Zilionis, Rapolas et al. (2017) Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils. Science 358:
Sawchuk, Craig N; Van Dyke, Emily; Omidpanah, Adam et al. (2016) Barriers to Cancer Care among American Indians and Alaska Natives. J Health Care Poor Underserved 27:84-96
Blacksher, Erika; Nelson, Charlene; Van Dyke, Emily et al. (2016) Conversations about Community-Based Participatory Research and Trust: ""We Are Explorers Together"". Prog Community Health Partnersh 10:305-9
Morris, Arden M; Doorenbos, Ardith Z; Haozous, Emily et al. (2016) Perceptions of cancer treatment decision making among American Indians/Alaska Natives and their physicians. Psychooncology 25:1050-6
Winer, Rachel L; Gonzales, Angela A; Noonan, Carolyn J et al. (2016) A Cluster-Randomized Trial to Evaluate a Mother-Daughter Dyadic Educational Intervention for Increasing HPV Vaccination Coverage in American Indian Girls. J Community Health 41:274-81
Simianu, Vlad V; Morris, Arden M; Varghese Jr, Thomas K et al. (2016) Evaluating disparities in inpatient surgical cancer care among American Indian/Alaska Native patients. Am J Surg 212:297-304
Winer, Rachel L; Gonzales, Angela A; Noonan, Carolyn J et al. (2016) Assessing Acceptability of Self-Sampling Kits, Prevalence, and Risk Factors for Human Papillomavirus Infection in American Indian Women. J Community Health 41:1049-61
Hiratsuka, Vanessa Y; Suchy-Dicey, Astrid M; Garroutte, Eva M et al. (2016) Patient and Provider Factors Associated With American Indian and Alaska Native Adolescent Tobacco Use Screening. J Prim Care Community Health 7:2-9
Haozous, Emily A; Doorenbos, Ardith; Alvord, Lori A et al. (2016) Cancer Journey for American Indians and Alaska Natives in the Pacific Northwest?. Oncol Nurs Forum 43:625-35

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