This proposal focuses on understanding the relationship between dietary patterns and risk of obesity in Hispanic women. This is an important issue in the realm of health disparities because neariy 80% of Hispanic women in the United States are ovenweight or obese and obesity increases risk for numerous chronic diseases, including breast cancer. The overall goal of this project Is to test the metabolic response to Western -and Indigenous Mexican diets in Hispanic women. We will also investigate whether ancestral genetic variation mediates the response to each diet. We hypothesize that the biological response to a Western dietary pattern produces detrimental metabolic profiles favoring adipose deposition, which leads to increased risk of adverse health events, including increased risk of breast cancer. Conversely, we hypothesize that the physiologic response to an Indigenous Mexican diet will produce a favorable metabolic profile. We further hypothesize that genetic ancestry mediates this biological response to a Western dietary pattern. Our primary aims are: (1) To test in a randomized cross-over experimental feeding study the metabolic response to an Indigenous Mexican diet vs. a Western diet in 50 first and second generation Hispanic women living in the greater Seattle area. The metabolic response will be measured by blood concentrations ofthe following biomarkers assessed before and after each feeding period: insulin, glucose, IGFI, IGFBP3, leptin, adiponectin, IL-6, CRP and SAA;and (2) To investigate whether genetic characteristics, as assessed with Ancestry Informative Markers, mediate the metabolic response to each tested diet. As secondary alms we will examine measures of hunger and satiety during each diet test period and genetic predictors of adiposity. This project will provide important data for understanding the etiology of obesity in i-lispanic women, which can be used to design effective programs for prevention.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA148143-04
Application #
8495080
Study Section
Special Emphasis Panel (ZCA1-SRLB-3)
Project Start
Project End
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
4
Fiscal Year
2013
Total Cost
$178,979
Indirect Cost
Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
078200995
City
Seattle
State
WA
Country
United States
Zip Code
98109
Santiago-Torres, M; De Dieu Tapsoba, J; Kratz, M et al. (2017) Genetic ancestry in relation to the metabolic response to a US versus traditional Mexican diet: a randomized crossover feeding trial among women of Mexican descent. Eur J Clin Nutr 71:395-401
Molina, Yamile; Beresford, Shirley A A; Thompson, Beti (2017) Psychological Outcomes After a False Positive Mammogram: Preliminary Evidence for Ethnic Differences Across Time. J Racial Ethn Health Disparities 4:123-133
Molina, Yamile; Glassgow, Anne E; Kim, Sage J et al. (2017) Patient Navigation in Medically Underserved Areas study design: A trial with implications for efficacy, effect modification, and full continuum assessment. Contemp Clin Trials 53:29-35
Molina, Yamile; Beresford, Shirley A A; Hayes Constant, Tara et al. (2017) Conversations about Abnormal Mammograms on Distress and Timely Follow-up Across Ethnicity. J Cancer Educ 32:320-327
Thompson, Beti; Carosso, Elizabeth A; Jhingan, Esther et al. (2017) Results of a randomized controlled trial to increase cervical cancer screening among rural Latinas. Cancer 123:666-674
Scheel, John R; Molina, Yamile; Coronado, Gloria et al. (2017) Healthcare Factors for Obtaining a Mammogram in Latinas With a Variable Mammography History. Oncol Nurs Forum 44:66-76
Molina, Yamile; Plascak, Jesse J; Patrick, Donald L et al. (2017) Neighborhood Predictors of Mammography Barriers Among US-Based Latinas. J Racial Ethn Health Disparities 4:233-242
Smith, Caren E; Fullerton, Stephanie M; Dookeran, Keith A et al. (2016) Using Genetic Technologies To Reduce, Rather Than Widen, Health Disparities. Health Aff (Millwood) 35:1367-73
Thompson, Beti; Molina, Yamile; Viswanath, Kasisomayajula et al. (2016) Strategies To Empower Communities To Reduce Health Disparities. Health Aff (Millwood) 35:1424-8
Chen, Lu; Li, Christopher I; Tang, Mei-Tzu C et al. (2016) Reproductive Factors and Risk of Luminal, HER2-Overexpressing, and Triple-Negative Breast Cancer Among Multiethnic Women. Cancer Epidemiol Biomarkers Prev 25:1297-304

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