This proposal focuses on understanding the relationship between dietary patterns and risk of obesity in Hispanic women. This is an important issue in the realm of health disparities because neariy 80% of Hispanic women in the United States are ovenweight or obese and obesity increases risk for numerous chronic diseases, including breast cancer. The overall goal of this project Is to test the metabolic response to Western -and Indigenous Mexican diets in Hispanic women. We will also investigate whether ancestral genetic variation mediates the response to each diet. We hypothesize that the biological response to a Western dietary pattern produces detrimental metabolic profiles favoring adipose deposition, which leads to increased risk of adverse health events, including increased risk of breast cancer. Conversely, we hypothesize that the physiologic response to an Indigenous Mexican diet will produce a favorable metabolic profile. We further hypothesize that genetic ancestry mediates this biological response to a Western dietary pattern. Our primary aims are: (1) To test in a randomized cross-over experimental feeding study the metabolic response to an Indigenous Mexican diet vs. a Western diet in 50 first and second generation Hispanic women living in the greater Seattle area. The metabolic response will be measured by blood concentrations ofthe following biomarkers assessed before and after each feeding period: insulin, glucose, IGFI, IGFBP3, leptin, adiponectin, IL-6, CRP and SAA;and (2) To investigate whether genetic characteristics, as assessed with Ancestry Informative Markers, mediate the metabolic response to each tested diet. As secondary alms we will examine measures of hunger and satiety during each diet test period and genetic predictors of adiposity. This project will provide important data for understanding the etiology of obesity in i-lispanic women, which can be used to design effective programs for prevention.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA148143-05
Application #
8725069
Study Section
Special Emphasis Panel (ZCA1-SRLB-3)
Project Start
Project End
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
5
Fiscal Year
2014
Total Cost
$138,564
Indirect Cost
Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
078200995
City
Seattle
State
WA
Country
United States
Zip Code
98109
Molina, Yamile; Hempstead, Bridgette H; Thompson-Dodd, Jacci et al. (2015) Medical Advocacy and Supportive Environments for African-Americans Following Abnormal Mammograms. J Cancer Educ 30:447-52
Molina, Yamile; Lehavot, Keren; Beadnell, Blair et al. (2014) Racial Disparities in Health Behaviors and Conditions Among Lesbian and Bisexual Women: The Role of Internalized Stigma. LGBT Health 1:131-139
Coronado, Gloria D; Gutierrez, Javiera Martinez; Jhingan, Esther et al. (2014) Patient and clinical perspectives on changes to mammography screening guidelines. Breast J 20:105-6
Coronado, Gloria D; Jimenez, Ricardo; Martinez-Gutierrez, Javiera et al. (2014) Multi-level Intervention to increase participation in mammography screening: ¬°Fortaleza Latina! study design. Contemp Clin Trials 38:350-4
Molina, Yamile; Hohl, Sarah D; Ko, Linda K et al. (2014) Understanding the patient-provider communication needs and experiences of Latina and non-Latina White women following an abnormal mammogram. J Cancer Educ 29:781-9
Molina, Yamile; Yi, Jean C; Martinez-Gutierrez, Javiera et al. (2014) Resilience among patients across the cancer continuum: diverse perspectives. Clin J Oncol Nurs 18:93-101
Molina, Yamile; Kim, Sage; Berrios, Nerida et al. (2014) Medical mistrust and patient satisfaction with mammography: the mediating effects of perceived self-efficacy among navigated African American women. Health Expect :
Molina, Yamile; Beresford, Shirley A A; Espinoza, Noah et al. (2014) Psychological distress, social withdrawal, and coping following receipt of an abnormal mammogram among different ethnicities: a mediation model. Oncol Nurs Forum 41:523-32
Molina, Y; Ramirez-Valles, J (2013) HIV/AIDS stigma: measurement and relationships to psycho-behavioral factors in Latino gay/bisexual men and transgender women. AIDS Care 25:1559-68
Balsam, Kimberly F; Beadnell, Blair; Molina, Yamile (2013) The Daily Heterosexist Experiences Questionnaire: Measuring Minority Stress Among Lesbian, Gay, Bisexual, and Transgender Adults. Meas Eval Couns Dev 46:3-25

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