The Genetics core will coordinate the collection of genotype data for the appropriate projects. These data will primarily be ancestry informative markers (AIMs) for the estimation of individual ancestry. The core will both lead the selection of AIMs for the project, to provide maximal information in the Latina populations studied, as well as actually generate the ancestry estimates. The actual collection of the genotype data will be performed in year 5 of the project, for three reasons. First, genotyping is much more cost effective (and technically consistent) when performed in a single batch. Because several of the projects may not complete recruitment until year 4, it is prudent to delay genotyping until recruitment is complete. The other reason to push genotyping into year 4 is technical: not only is it likely that AIM panels will tie refined for Hispanic populations over the coming years, but the cost of collecting genotypes tends to decrease with each year. Thus, by delaying the genotype collection effort until all samples are available, we can maximize the information content of the AIM panel, and minimize the cost of collecting the data.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA148143-05
Application #
8725074
Study Section
Special Emphasis Panel (ZCA1-SRLB-3)
Project Start
Project End
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
5
Fiscal Year
2014
Total Cost
$2,737
Indirect Cost
Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
078200995
City
Seattle
State
WA
Country
United States
Zip Code
98109
Chen, Lu; Li, Christopher I; Tang, Mei-Tzu C et al. (2016) Reproductive Factors and Risk of Luminal, HER2-Overexpressing, and Triple-Negative Breast Cancer Among Multiethnic Women. Cancer Epidemiol Biomarkers Prev 25:1297-304
Thompson, Beti; Carosso, Elizabeth A; Jhingan, Esther et al. (2016) Results of a randomized controlled trial to increase cervical cancer screening among rural Latinas. Cancer :
Smith, Caren E; Fullerton, Stephanie M; Dookeran, Keith A et al. (2016) Using Genetic Technologies To Reduce, Rather Than Widen, Health Disparities. Health Aff (Millwood) 35:1367-73
Molina, Yamile; Beresford, Shirley A A; Thompson, Beti (2016) Psychological Outcomes After a False Positive Mammogram: Preliminary Evidence for Ethnic Differences Across Time. J Racial Ethn Health Disparities :
Hohl, Sarah D; Thompson, Beti; Krok-Schoen, Jessica L et al. (2016) Characterizing Community Health Workers on Research Teams: Results From the Centers for Population Health and Health Disparities. Am J Public Health 106:664-70
Santiago-Torres, Margarita; Kratz, Mario; Lampe, Johanna W et al. (2016) Metabolic responses to a traditional Mexican diet compared with a commonly consumed US diet in women of Mexican descent: a randomized crossover feeding trial. Am J Clin Nutr 103:366-74
Malen, Rachel; Knerr, Sarah; Delgado, Fernanda et al. (2016) Rural Mexican-Americans' perceptions of family health history, genetics, and disease risk: implications for disparities-focused research dissemination. J Community Genet 7:91-6
Santiago-Torres, M; De Dieu Tapsoba, J; Kratz, M et al. (2016) Genetic ancestry in relation to the metabolic response to a US versus traditional Mexican diet: a randomized crossover feeding trial among women of Mexican descent. Eur J Clin Nutr :
Molina, Yamile; Hohl, Sarah D; Nguyen, Michelle et al. (2016) Ethnic differences in social support after initial receipt of an abnormal mammogram. Cultur Divers Ethnic Minor Psychol 22:588-593
Molina, Yamile; Plascak, Jesse J; Patrick, Donald L et al. (2016) Neighborhood Predictors of Mammography Barriers Among US-Based Latinas. J Racial Ethn Health Disparities :

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