The overall objective of the Case Gl SPORE Career Development Program (SCDP) is to develop the next generation of Gl Cancer Translational Scholars who are 1) trained in the broad fundamentals of Gl cancer pathobiology;2) ready to lead an independent translational Gl cancer research program;3) oriented and able to most effectively utilize innovative translational and transdisciplinary science approaches to attack and solve problems associated with Gl malignancies;4) committed to improving all aspects of patient health relevant to Gl malignancies across the spectrum from etiology through prevention, screening, diagnosis, therapy and survivorship, and 5) prepared with sufficient understanding of academic policies and institutional, community and national resources to most effectively support program development and promote academic advancement. The Gl SCDP builds on a strong track record of preparing trainees for successful careers in Gl Cancer Care and Research will support up to 4 SCDP Scholars per year with funds provided from the SPORE Grant, the Case Comprehensive Cancer Center and its NCI sponsored K12 award. Opportunities for translational research training will be provided in collaboration with the CWRU and Clinical Translational Science Award (CTSA) - KL2 Career Development Program. Scholars will be provided with 75% protected time for research and career training. The training program will consist of 4 main core components: 1) Research Project;2) Research Training;3) Multidisciplinary Mentoring and 4) Structured Research and Career Development Planning. Each scholar will be provided with a team of 3 mentors including 1) a Research Project Mentor, 2) a Translational Research Mentor, and 3) a Career Development Mentor to guide the scholars to develop successful research and academic careers focused on translational Gl Cancer Research. Scholars progress and performance and that of the overall program will be monitored by the SCDP Scholars Council and scholars will be recruited on both a national and local level with special efforts made to recruit women and members of underrepresented ethnic groups.

Public Health Relevance

The Case Gl SPORE Career Development Program will provide a series of 2 year career training opportunities to prepare investigators for careers in translational Gl Cancer research. Selected applicants will have 75% protected time for research and training and will conduct a mentored research project with oversight provided by a research mentor, a translational mentor and a career development mentor.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA150964-03
Application #
8567140
Study Section
Special Emphasis Panel (ZCA1-RPRB-M)
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
3
Fiscal Year
2013
Total Cost
$126,111
Indirect Cost
$43,750
Name
Case Western Reserve University
Department
Type
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Venkitachalam, Srividya; Guda, Kishore (2017) Altered glycosyltransferases in colorectal cancer. Expert Rev Gastroenterol Hepatol 11:5-7
Arif, Abul; Terenzi, Fulvia; Potdar, Alka A et al. (2017) EPRS is a critical mTORC1-S6K1 effector that influences adiposity in mice. Nature 542:357-361
Morris, Shelli M; Davison, Jerry; Carter, Kelly T et al. (2017) Transposon mutagenesis identifies candidate genes that cooperate with loss of transforming growth factor-beta signaling in mouse intestinal neoplasms. Int J Cancer 140:853-863
Cummings, Linda C; Thota, Prashanthi N; Willis, Joseph E et al. (2017) A nonrandomized trial of vitamin D supplementation for Barrett's esophagus. PLoS One 12:e0184928
Hu, Xiao; He, Yanhua; Wu, Liping et al. (2017) Novel all-hydrocarbon stapled p110?[E545K] peptides as blockers of the oncogenic p110?[E545K]-IRS1 interaction. Bioorg Med Chem Lett 27:5446-5449
Zhao, Yiqing; Scott, Anthony; Zhang, Peng et al. (2017) Regulation of paxillin-p130-PI3K-AKT signaling axis by Src and PTPRT impacts colon tumorigenesis. Oncotarget 8:48782-48793
Luebeck, E Georg; Curtius, Kit; Hazelton, William D et al. (2017) Identification of a key role of widespread epigenetic drift in Barrett's esophagus and esophageal adenocarcinoma. Clin Epigenetics 9:113
Petersen, Christine P; Meyer, Anne R; De Salvo, Carlo et al. (2017) A signalling cascade of IL-33 to IL-13 regulates metaplasia in the mouse stomach. Gut :
Kim, Jaeil; Do, Eun-Ju; Moinova, Helen et al. (2017) Molecular Imaging of Colorectal Tumors by Targeting Colon Cancer Secreted Protein-2 (CCSP-2). Neoplasia 19:805-816
Cohen, Andrea J; Saiakhova, Alina; Corradin, Olivia et al. (2017) Hotspots of aberrant enhancer activity punctuate the colorectal cancer epigenome. Nat Commun 8:14400

Showing the most recent 10 out of 127 publications