The goal of Administration Core is to ensure that translational goals of the RPCI-UPCI Ovarian Cancer SPORE are met and that resources are used effectively. The Administration Core will provide leadership, direction and administrative services for the purposes of enhancing research productivity and maintaining a stimulating translational research environment for ovarian cancer. The Administration Core will provide a platform to assure integration of diverse scientific disciplines into a unified multidisciplinary approach for achieving excellence in translational research in ovarian cancer. The Administration Core will be organized to meet 4 primary objectives, the provision of 1) Leadership;2) Administrative Management;3) Data and Communications Management;and 4) Scientific Management. The Leadership objective will be met by an MD-PhD team with many years of experience leading large, complex, multi-institutional research efforts in ovarian cancer. The Administrative Management objective will be met through proper adherence to the financial commitments and scientific support made by RPCI and UPCI, responsible project management by the Program Manager and by strong administrative support. The Data and Communications Management objective will be met by the creation of a Central Database that will be used to track all research subjects and specimens, house all data generated, and facilitate data analysis, and a website accessible by the RPCI-UPCI Ovarian Cancer SPORE investigators, investigators from other NCI Ovarian Cancer SPORE grants, research subjects, and the general public. The Scientific Management objective will be met by close supervision of the RPCI-UPCI Ovarian Cancer SPORE by the Executive Committee, and Internal and External Advisory Boards. The Administration Core will foster the exchange of ideas and promote collaboration through its interactions with the Individual Research Project Leaders, Developmental Research Program Project Leaders, Career Developmental Program Project Leaders, Core Directors and all members of the research groups. Importantly, the Administration Core will monitor timelines and ensure that the translational objectives are met for all SPORE projects. The Administration Core will have direct responsibility for organization and facilitation of annual reviews of the Individual Research Projects, Developmental Research Program projects. Career Developmental Program projects, Tissue Core, Biostatistics and Bioinformatics Core, and the Immune Analysis Core by the Internal and External Advisory Boards and organization of an annual scientific retreat.

Public Health Relevance

The Administration Core will make the RPCI-UPCI Ovarian Cancer SPORE more relevant to ovarian cancer research by providing effective leadership and administrative support for a broad range of SPORE-related activities to ensure optimal progress and performance of all leaders, investigators, projects, cores, and developmental research and career development programs.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center (P50)
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Special Emphasis Panel (ZCA1-RPRB-M (J1))
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Roswell Park Cancer Institute Corp
United States
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Szender, J Brian; Eng, Kevin H; Matsuzaki, Junko et al. (2016) HLA superfamily assignment is a predictor of immune response to cancer testis antigens and survival in ovarian cancer. Gynecol Oncol 142:158-62
Kohrt, Holbrook E; Tumeh, Paul C; Benson, Don et al. (2016) Immunodynamics: a cancer immunotherapy trials network review of immune monitoring in immuno-oncology clinical trials. J Immunother Cancer 4:15
Chen, Yichao; Xia, Rui; Huang, Yixian et al. (2016) An immunostimulatory dual-functional nanocarrier that improves cancer immunochemotherapy. Nat Commun 7:13443
Wong, Jeffrey L; Obermajer, Nataša; Odunsi, Kunle et al. (2016) Synergistic COX2 Induction by IFNγ and TNFα Self-Limits Type-1 Immunity in the Human Tumor Microenvironment. Cancer Immunol Res 4:303-11
Shi, Liangrong; Chen, Lujun; Wu, Changping et al. (2016) PD-1 Blockade Boosts Radiofrequency Ablation-Elicited Adaptive Immune Responses against Tumor. Clin Cancer Res 22:1173-84
Cuellar-Partida, Gabriel; Lu, Yi; Dixon, Suzanne C et al. (2016) Assessing the genetic architecture of epithelial ovarian cancer histological subtypes. Hum Genet 135:741-56
Winham, Stacey J; Pirie, Ailith; Chen, Yian Ann et al. (2016) Investigation of Exomic Variants Associated with Overall Survival in Ovarian Cancer. Cancer Epidemiol Biomarkers Prev 25:446-54
Præstegaard, Camilla; Kjaer, Susanne K; Nielsen, Thor S S et al. (2016) The association between socioeconomic status and tumour stage at diagnosis of ovarian cancer: A pooled analysis of 18 case-control studies. Cancer Epidemiol 41:71-9
Earp, Madalene; Winham, Stacey J; Larson, Nicholas et al. (2016) A targeted genetic association study of epithelial ovarian cancer susceptibility. Oncotarget 7:7381-9
Zhao, Wenyuan; Chen, Beibei; Guo, Xin et al. (2016) A rank-based transcriptional signature for predicting relapse risk of stage II colorectal cancer identified with proper data sources. Oncotarget 7:19060-71

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