The goal of Administration Core is to ensure that translational goals of the RPCI-UPCI Ovarian Cancer SPORE are met and that resources are used effectively. The Administration Core will provide leadership, direction and administrative services for the purposes of enhancing research productivity and maintaining a stimulating translational research environment for ovarian cancer. The Administration Core will provide a platform to assure integration of diverse scientific disciplines into a unified multidisciplinary approach for achieving excellence in translational research in ovarian cancer. The Administration Core will be organized to meet 4 primary objectives, the provision of 1) Leadership;2) Administrative Management;3) Data and Communications Management;and 4) Scientific Management. The Leadership objective will be met by an MD-PhD team with many years of experience leading large, complex, multi-institutional research efforts in ovarian cancer. The Administrative Management objective will be met through proper adherence to the financial commitments and scientific support made by RPCI and UPCI, responsible project management by the Program Manager and by strong administrative support. The Data and Communications Management objective will be met by the creation of a Central Database that will be used to track all research subjects and specimens, house all data generated, and facilitate data analysis, and a website accessible by the RPCI-UPCI Ovarian Cancer SPORE investigators, investigators from other NCI Ovarian Cancer SPORE grants, research subjects, and the general public. The Scientific Management objective will be met by close supervision of the RPCI-UPCI Ovarian Cancer SPORE by the Executive Committee, and Internal and External Advisory Boards. The Administration Core will foster the exchange of ideas and promote collaboration through its interactions with the Individual Research Project Leaders, Developmental Research Program Project Leaders, Career Developmental Program Project Leaders, Core Directors and all members of the research groups. Importantly, the Administration Core will monitor timelines and ensure that the translational objectives are met for all SPORE projects. The Administration Core will have direct responsibility for organization and facilitation of annual reviews of the Individual Research Projects, Developmental Research Program projects. Career Developmental Program projects, Tissue Core, Biostatistics and Bioinformatics Core, and the Immune Analysis Core by the Internal and External Advisory Boards and organization of an annual scientific retreat.

Public Health Relevance

The Administration Core will make the RPCI-UPCI Ovarian Cancer SPORE more relevant to ovarian cancer research by providing effective leadership and administrative support for a broad range of SPORE-related activities to ensure optimal progress and performance of all leaders, investigators, projects, cores, and developmental research and career development programs.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
1P50CA159981-01A1
Application #
8485814
Study Section
Special Emphasis Panel (ZCA1-RPRB-M (J1))
Project Start
2013-09-18
Project End
2018-06-30
Budget Start
2013-09-18
Budget End
2014-06-30
Support Year
1
Fiscal Year
2013
Total Cost
$171,210
Indirect Cost
$28,163
Name
Roswell Park Cancer Institute Corp
Department
Type
DUNS #
824771034
City
Buffalo
State
NY
Country
United States
Zip Code
14263
Block, Matthew S; Vierkant, Robert A; Rambau, Peter F et al. (2018) MyD88 and TLR4 Expression in Epithelial Ovarian Cancer. Mayo Clin Proc 93:307-320
Wang, Zehua; Yang, Bo; Zhang, Min et al. (2018) lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer. Cancer Cell 33:706-720.e9
Mayor, Paul C; Eng, Kevin H; Singel, Kelly L et al. (2018) Cancer in primary immunodeficiency diseases: Cancer incidence in the United States Immune Deficiency Network Registry. J Allergy Clin Immunol 141:1028-1035
Harris, Holly R; Babic, Ana; Webb, Penelope M et al. (2018) Polycystic Ovary Syndrome, Oligomenorrhea, and Risk of Ovarian Cancer Histotypes: Evidence from the Ovarian Cancer Association Consortium. Cancer Epidemiol Biomarkers Prev 27:174-182
Shenoy, Gautam N; Loyall, Jenni; Berenson, Charles S et al. (2018) Sialic Acid-Dependent Inhibition of T Cells by Exosomal Ganglioside GD3 in Ovarian Tumor Microenvironments. J Immunol 201:3750-3758
Lu, Yingchang; Beeghly-Fadiel, Alicia; Wu, Lang et al. (2018) A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk. Cancer Res 78:5419-5430
Wang, Yue; Wang, Zehua; Xu, Jieni et al. (2018) Systematic identification of non-coding pharmacogenomic landscape in cancer. Nat Commun 9:3192
Minlikeeva, Albina N; Moysich, Kirsten B; Mayor, Paul C et al. (2018) Anthropometric characteristics and ovarian cancer risk and survival. Cancer Causes Control 29:201-212
Peres, Lauren C; Risch, Harvey; Terry, Kathryn L et al. (2018) Racial/ethnic differences in the epidemiology of ovarian cancer: a pooled analysis of 12 case-control studies. Int J Epidemiol 47:460-472
Szender, J Brian; Kaur, Jasmine; Clayback, Katherine et al. (2018) Breadth of Genetic Testing Selected by Patients at Risk of Hereditary Breast and Ovarian Cancer. Int J Gynecol Cancer 28:26-33

Showing the most recent 10 out of 128 publications