Quantitative evaluation of data is the foundation of scientific research. The Biostatistics Core provides resources to assist in the planning, conduct and analysis of the proposed research in such a way that quantitative analyses are appropriate and illuminating. The Core also assists in the dissemination of appropriate information both within and external to the SPORE and the Siteman Cancer Center (SCC). This core represents an extension of the strong Biostatistics Core within the Siteman Cancer Center, and funding is only requested for the SPORE-specific support required. This efficient model takes advantage of the core infrastructure in place. The Core is staffed by a dedicated biostatistician for each of the 4 projects. In addition a designated faculty member is devoted to collaborations concerning specialized bioinformatics issues. The Core staff are collaborators with the Project Co-leaders. The staff of the Core will meet weekly among themselves and regulariy with Project leaders to review the progress in each Project and the SPORE overall and to discuss methodological issues. The Biostatistics Core will serve as a resource and collaborator for the four main projects proposed in this application. Career Development Program and Developmental Research Program projects and the SPORE Cores. Specifically the Biostatistics Core will: 1. Continue to participate in the design of all projects (including developmental and career development) and will advocate for the application of appropriate statistical and methodological techniques. 2. Continue to merge information from the SPORE research with information about samples that have been entered into caTISSUE which is supported by the SPORE Tissue and Pathology Core to produce analytic datasets which are deidentified and easily distributed to investigators. 3. Collaborate in data analysis and report preparation for all Cores and Projects. 4. Collaborate in the design of all forms to be used. 5. Support data entry and data management procedures to achieve cost-effective data acquisition. 6. Facilitate access to data collected by the projects and cores.

Public Health Relevance

This shared resource will acquire and store tissue samples (blood and bone marrow) from patients with leukemia. These samples will be invaluable to investigators as they test new hypotheses and therapies.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
1P50CA171963-01A1
Application #
8595808
Study Section
Special Emphasis Panel (ZCA1-RPRB-0 (M1))
Project Start
2013-09-03
Project End
2018-06-30
Budget Start
2013-09-03
Budget End
2014-06-30
Support Year
1
Fiscal Year
2013
Total Cost
$183,799
Indirect Cost
$79,913
Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Wagner, Julia A; Berrien-Elliott, Melissa M; Rosario, Maximillian et al. (2017) Cytokine-Induced Memory-Like Differentiation Enhances Unlicensed Natural Killer Cell Antileukemia and Fc?RIIIa-Triggered Responses. Biol Blood Marrow Transplant 23:398-404
Uy, G L; Duncavage, E J; Chang, G S et al. (2017) Dynamic changes in the clonal structure of MDS and AML in response to epigenetic therapy. Leukemia 31:872-881
Saez, Borja; Walter, Matthew J; Graubert, Timothy A (2017) Splicing factor gene mutations in hematologic malignancies. Blood 129:1260-1269
Cooper, Matthew L; Choi, Jaebok; Karpova, Darja et al. (2017) Azacitidine Mitigates Graft-versus-Host Disease via Differential Effects on the Proliferation of T Effectors and Natural Regulatory T Cells In Vivo. J Immunol 198:3746-3754
Duncavage, Eric J; Uy, Geoffrey L; Petti, Allegra A et al. (2017) Mutational landscape and response are conserved in peripheral blood of AML and MDS patients during decitabine therapy. Blood 129:1397-1401
Shirai, Cara Lunn; White, Brian S; Tripathi, Manorama et al. (2017) Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome. Nat Commun 8:14060
Schroeder, Mark A; Choi, Jaebok; Staser, Karl et al. (2017) The Role of Janus Kinase Signaling in Graft-Versus-Host Disease and Graft Versus Leukemia. Biol Blood Marrow Transplant :
How, Joan; Slade, Michael; Vu, Khoan et al. (2017) T Cell-Replete Peripheral Blood Haploidentical Hematopoietic Cell Transplantation with Post-Transplantation Cyclophosphamide Results in Outcomes Similar to Transplantation from Traditionally Matched Donors in Active Disease Acute Myeloid Leukemia. Biol Blood Marrow Transplant 23:648-653
Ali, Alaa M; Weisel, Daniel; Gao, Feng et al. (2017) Patterns of infectious complications in acute myeloid leukemia and myelodysplastic syndromes patients treated with 10-day decitabine regimen. Cancer Med 6:2814-2821
Romee, Rizwan; Rosario, Maximillian; Berrien-Elliott, Melissa M et al. (2016) Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia. Sci Transl Med 8:357ra123

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