This Core serves two functions. The first is to provide a service to other TCORS investigators by carrying out the analysis of biofluid samples for their studies. The second is to develop new biomarkers of exposure that can be applied to the studies carried out by TCORS investigators, as well as to advance the field. Our laboratory is able to measure alkaloids and toxic substances in both tobacco products and in tobacco smoke. These measurements are needed for biomarker development and to interpret the biomarker data for distinguishing smokeless from smoked tobacco use. These measurements will include other substances in order to explore relationships between toxins and toxin precursors in tobacco and smoke with exposure determined using biomarkers. The improved exposure assessment measures that we expect to develop, and their application to studies carried out by the TCORS, could serve as models for future studies of the risks of new tobacco products and provide scientific basis for their regulation.

Public Health Relevance

The development and validation of biomarkers is a high priority issue for FDA regulation. Studies of tobacco product chemistry with biomarker analyses may provide information on which substances are associated with toxin exposure in humans. Precursors in smoking products that generate toxic substances might provide leads for reducing the toxicity of new products or be targets for regulation. We expect that our studies will result in improved methods for determining human exposure to toxic substances in tobacco and tobacco smoke.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
1P50CA180890-01
Application #
8592344
Study Section
Special Emphasis Panel (ZRG1-BDCN-Q (40))
Project Start
2013-09-19
Project End
2018-08-31
Budget Start
2013-09-19
Budget End
2014-08-31
Support Year
1
Fiscal Year
2013
Total Cost
$860,056
Indirect Cost
$284,619
Name
University of California San Francisco
Department
Type
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Wang, Yingning; Sung, Hai-Yen; Yao, Tingting et al. (2016) Factors Associated with Short-Term Transitions of Nondaily Smokers: Socio-demographic Characteristics and Other Tobacco Product Use. Addiction :
Moazed, Farzad; Burnham, Ellen L; Vandivier, R William et al. (2016) Cigarette smokers have exaggerated alveolar barrier disruption in response to lipopolysaccharide inhalation. Thorax :
Yao, Tingting; Sung, Hai-Yen; Wang, Yingning et al. (2016) Sociodemographic Differences Among U.S. Children and Adults Exposed to Secondhand Smoke at Home: National Health Interview Surveys 2000 and 2010. Public Health Rep 131:357-66
Liu, Jiangtao; Wang, Xiaoyin; Narayan, Shilpa et al. (2016) Impairment of Endothelial Function by Little Cigar Secondhand Smoke. Tob Regul Sci 2:56-63
Lempert, Lauren K; Glantz, Stanton (2016) Packaging colour research by tobacco companies: the pack as a product characteristic. Tob Control :
Dutra, Lauren M; Grana, Rachel; Glantz, Stanton A (2016) Philip Morris research on precursors to the modern e-cigarette since 1990. Tob Control :
St Helen, Gideon; Havel, Christopher; Dempsey, Delia A et al. (2016) Nicotine delivery, retention and pharmacokinetics from various electronic cigarettes. Addiction 111:535-44
Wang, Julie B; Cataldo, Janine K (2016) Medical Marijuana Legalization and Co-use in Adult Cigarette Smokers. Am J Health Behav 40:205-14
Roditis, Maria; Delucchi, Kevin; Cash, David et al. (2016) Adolescents' Perceptions of Health Risks, Social Risks, and Benefits Differ Across Tobacco Products. J Adolesc Health 58:558-66
Couch, Elizabeth T; Darius, Ellen; Walsh, Margaret M et al. (2016) Smokeless Tobacco Decision-Making Among Rural Adolescent Males in California. J Community Health :

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