The overarching theme of this Tobacco Center of Regulatory Science is the development of improved models to inform tobacco product regulatory strategies that integrate 1) economic impacts of tobacco use on health costs, 2) risk perceptions, perceived acceptability, consumer responses to pro-tobacco marketing and anti-tobacco messages and other social determinants of tobacco use, and 3) rapid changes in risk due to tobacco use and secondhand smoke exposure as manifested in cardiovascular and pulmonary dysfunction. This TCORS includes five full projects (one on economic models, two on behavioral models, and two on cardiovascular and pulmonary disease models), two developmental projects (one on behavioral models and one on cardiovascular and pulmonary disease models), three Cores (Administrative, Informatics and Analysis, and Biomarker), a postdoctoral training program and a process for selecting future developmental projects. The results will inform FDA regulation of the manufacture, distribution and marketing of tobacco products by providing an improved scientific framework in which to evaluate the likely effects of specific regulatory strategies by developing 1) improved economic models for analysis of proposed regulations that account for short-term as well as long-term effects of tobacco use, 2) better understanding of behavioral and social determinants of tobacco use (including perception of risk and decision making processes) to inform the economic models, regulation of marketing, and public education about risks of tobacco products, and 3) functional biomarkers of acute cardiopulmonary responses to tobacco use and secondhand smoke that may predict future disease and also support development of improved economic models. In particular, these improved economic models will integrate the rapid changes in risk due to reductions in cardiovascular and pulmonary diseases which would be expected to result from FDA regulatory decisions. This TCORS is built on the UCSF Center for Tobacco Control Research and Education's tradition of strong transdisciplinary and collaborative research, education and service.
This TCORS will inform FDA regulation by developing new economic models that account for short-term and long-term effects of tobacco use, developing a better understanding of behavioral determinants of tobacco use, and identifying functional biomarkers of acute cardiopulmonary responses to tobacco use that could be used in premarket testing of tobacco products.
|Kim, Minji (2017) Philip Morris International introduces new heat-not-burn product, IQOS, in South Korea. Tob Control :|
|Gotts, Jeffrey E; Abbott, Jason; Fang, Xiaohui et al. (2017) Cigarette Smoke Exposure Worsens Endotoxin-Induced Lung Injury and Pulmonary Edema in Mice. Nicotine Tob Res 19:1033-1039|
|Chaffee, Benjamin W; Couch, Elizabeth T; Gansky, Stuart A (2017) Adolescents' smokeless tobacco susceptibility by perceived professional baseball players' use. J Public Health Dent :|
|Benowitz, Neal L; Fraiman, Joseph B (2017) Cardiovascular effects of electronic cigarettes. Nat Rev Cardiol 14:447-456|
|Dutra, Lauren M; Glantz, Stanton A; Lisha, Nadra E et al. (2017) Beyond experimentation: Five trajectories of cigarette smoking in a longitudinal sample of youth. PLoS One 12:e0171808|
|Gibson, Laura A; Creamer, MeLisa R; Breland, Alison B et al. (2017) Measuring perceptions related to e-cigarettes: Important principles and next steps to enhance study validity. Addict Behav :|
|Couch, Elizabeth T; Darius, Ellen; Walsh, Margaret M et al. (2017) Smokeless Tobacco Decision-Making Among Rural Adolescent Males in California. J Community Health 42:544-550|
|St Helen, Gideon; Dempsey, Delia A; Havel, Christopher M et al. (2017) Impact of e-liquid flavors on nicotine intake and pharmacology of e-cigarettes. Drug Alcohol Depend 178:391-398|
|McKelvey, Karma; Halpern-Felsher, Bonnie (2017) Adolescent Cigarette Smoking Perceptions and Behavior: Tobacco Control Gains and Gaps Amidst the Rapidly Expanding Tobacco Products Market From 2001 to 2015. J Adolesc Health 60:226-228|
|Wang, Yingning; Sung, Hai-Yen; Lightwood, James et al. (2017) Healthcare Utilization and Expenditures Attributable to Smokeless Tobacco Use among US Adults. Nicotine Tob Res :|
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