Dr. Snyder will provide overall direction of the center comprising scientific, financial and administrative perspectives. He will be responsible for determining the intellectual direction of the program and for making appropriate changes when necessary. Administrative, scientific and financial functions he will address will include preparation of scientific progress reports and renewals, coordination and direction of research projects and their integration, and consultation with internal and external advisory committees as well as outside consultants. He will also be responsible for allocating budgets and organizing seminars and meetings related to the Center grant, justifying expenditures and handling all records and finances for the project. Snyder has served as center director throughout the 40 years of the center's existence and thus has substantial experience in successfully coordinating the research of Pis and ensuring high scientific standards. Snyder devotes at least 40% of his effort to the research and administrative activities of this grant with 20% devoted to center administration. In practice, generally more than half of his research time is devoted to the activities of the Center. Barbara Ziegler will serve as the administrative coordinator, handling the implementation of many of the functions described above. She will also prepare manuscripts, progress reports and correspondence. Additionally, she will serve as financial administrator of the project, maintaining records of all financial transactions. Ms. Ziegler has over ten years of experience in executing these functions.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Specialized Center (P50)
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Special Emphasis Panel (ZDA1-EXL-T)
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Johns Hopkins University
United States
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Hinkle, Jared T; Perepezko, Kate; Bakker, Catherine C et al. (2018) Domain-specific cognitive impairment in non-demented Parkinson's disease psychosis. Int J Geriatr Psychiatry 33:e131-e139
Hinkle, Jared T; Perepezko, Kate; Mills, Kelly A et al. (2018) Dopamine transporter availability reflects gastrointestinal dysautonomia in early Parkinson disease. Parkinsonism Relat Disord 55:8-14
Piard, Juliette; Umanah, George K Essien; Harms, Frederike L et al. (2018) A homozygous ATAD1 mutation impairs postsynaptic AMPA receptor trafficking and causes a lethal encephalopathy. Brain :
Hinkle, Jared T; Perepezko, Kate; Rosenthal, Liana S et al. (2018) Markers of impaired motor and cognitive volition in Parkinson's disease: Correlates of dopamine dysregulation syndrome, impulse control disorder, and dyskinesias. Parkinsonism Relat Disord 47:50-56
Berger, Nathan A; Besson, Valerie C; Boulares, A Hamid et al. (2018) Opportunities for the repurposing of PARP inhibitors for the therapy of non-oncological diseases. Br J Pharmacol 175:192-222
Chern, Yijuang; Chien, Ting; Fu, Xiuping et al. (2018) Trax: A versatile signaling protein plays key roles in synaptic plasticity and DNA repair. Neurobiol Learn Mem :
Paul, Bindu D; Snyder, Solomon H (2018) Gasotransmitter hydrogen sulfide signaling in neuronal health and disease. Biochem Pharmacol 149:101-109
Harraz, Maged M; Snyder, Solomon H (2017) Antidepressant Actions of Ketamine Mediated by the Mechanistic Target of Rapamycin, Nitric Oxide, and Rheb. Neurotherapeutics 14:728-733
Asrani, Kaushal; Sood, Akshay; Torres, Alba et al. (2017) mTORC1 loss impairs epidermal adhesion via TGF-?/Rho kinase activation. J Clin Invest 127:4001-4017
Dawson, Ted M; Dawson, Valina L (2017) Mitochondrial Mechanisms of Neuronal Cell Death: Potential Therapeutics. Annu Rev Pharmacol Toxicol 57:437-454

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