As all Center components will use genetically engineered mice, a central Animal Breeding Core (AB Core) will be used to meet the animal needs of all Center projects. The AB-Core was established in the previous funding cycle and developed a set of standardized procedures to accomplish this goal.
The aims of the AB-Core are as follows: 1. The AB-Core will co-ordinate with each component to provide the required cohorts of mice as needed. 2. The AB-Core will maintain each line under optimal breeding management practices. 3. As many components will utilize cross-bred lines, the AB-Core will ensure all lines are correctly maintained as congenic on the C57BL/6J background. 4. The AB-Core will follow the correct breeding strategies to ensure wild type and mutant mice are bred as littermates. 5. The AB-Core will verify that correct patterns of expression are achieved following cre- mediated deletion in both males and females.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZDA1-EXL-T)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California Los Angeles
Los Angeles
United States
Zip Code
Erbs, Eric; Faget, Lauren; Scherrer, Gregory et al. (2015) A mu-delta opioid receptor brain atlas reveals neuronal co-occurrence in subcortical networks. Brain Struct Funct 220:677-702
Wang, Nan; Gray, Michelle; Lu, Xiao-Hong et al. (2014) Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's disease. Nat Med 20:536-41
Wassum, Kate M; Greenfield, Venuz Y; Linker, Kay E et al. (2014) Inflated reward value in early opiate withdrawal. Addict Biol :
Ivanov, Iliyan; Liu, Xun; Clerkin, Suzanne et al. (2014) Methylphenidate and brain activity in a reward/conflict paradigm: role of the insula in task performance. Eur Neuropsychopharmacol 24:897-906
Tsoa, Rosemarie W; Coskun, Volkan; Ho, Chi K et al. (2014) Spatiotemporally different origins of NG2 progenitors produce cortical interneurons versus glia in the mammalian forebrain. Proc Natl Acad Sci U S A 111:7444-9
Taylor, Anna M W; Murphy, Niall P; Evans, Christopher J et al. (2014) Correlation between ventral striatal catecholamine content and nociceptive thresholds in neuropathic mice. J Pain 15:878-85
Ostlund, Sean B; Kosheleff, Alisa R; Maidment, Nigel T (2014) Differential effects of systemic cholinergic receptor blockade on Pavlovian incentive motivation and goal-directed action selection. Neuropsychopharmacology 39:1490-7
Becker, Jérôme A J; Clesse, Daniel; Spiegelhalter, Coralie et al. (2014) Autistic-like syndrome in mu opioid receptor null mice is relieved by facilitated mGluR4 activity. Neuropsychopharmacology 39:2049-60
Pradhan, Amynah A; Smith, Monique L; McGuire, Brenna et al. (2014) Characterization of a novel model of chronic migraine. Pain 155:269-74
Liu, Hailiang; Chen, Yongchang; Niu, Yuyu et al. (2014) TALEN-mediated gene mutagenesis in rhesus and cynomolgus monkeys. Cell Stem Cell 14:323-8

Showing the most recent 10 out of 36 publications