This competing renewal application proposes to continue the follow-up study of 800 families enrolled in the Center's prospective investigations into the etiology of substance use disorder (SUD). Proband fathers are ascertained on the basis of the presence or absence of SUD, and have a biological son or daughter between 10-12 years of age at baseline. Ascertainment criterion for SUD probands is a lifetime diagnosis (abuse or dependence) on any illegal compound or a compound consumed without medical prescription. The children of SUD men are assigned to the high average risk (HAR) group. Offspring of men without SUD are assigned to the low average risk (LAR) group. These children are currently in varying stages of follow-up evaluation conducted at ages 12-14, 16, 19, and annually thereafter until age 30. During the next five years it is anticipated that approximately 117 subjects undergoing the age 22 assessment will have succumbed to SUD; thus, the Center is at the stage where determination of SUD liability is a feasible undertaking. Comprehensive multidisciplinary protocols are administered to family members (father, mother, children, stepparents, 1st degree relatives of father and mother) with the objective of elucidating the genetic, biobehavioral, and environmental contributors of SUD liability. These protocols are organized into four thematically connected research modules (horizontal Center integration) which accrue the data to input to the Scientific Core (vertical integration) to achieve the Center's scientific goals. The Center, having the programmatic name Center for Education and Drug Abuse Research (CEDAR), is structured in 9 components (5 cores and 4 research modules): 1) Administrative Core (R. Tarter, Ph.D., M.P.A.), 2) Scientific Core (M. Vanyukov, Ph.D.), 3) Clinical Core (J. Cornelius, M.D., M.P.H.), 4) Computing and Information Systems Core (A. Mezzich, Ph.D., M.I.S.), 5) Methodology and Statistics Core (L. Kirisci, Ph.D.), 6) Developmental Psychopathology Module (D. Clark, M.D., Ph.D.), 7) Neurocognition Module (R. Tarter, Ph.D.), 8) Genetics Module (M. Vanyukov, Ph.D.), and, 9) Family and Social Ecology Module (M. Dunn, Ph.D.). In 2007, CEDAR will have completed 13 years of prospective investigation into the etiology of SUD. During the ensuing five years, research will be directed at characterizing SUD liability, development of the individual liability index, and empirically confirm/disconfirm CEDAR's theory of SUD etiology.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Specialized Center (P50)
Project #
2P50DA005605-14A2
Application #
6712062
Study Section
Special Emphasis Panel (ZDA1-RXL-E (20))
Program Officer
Conway, Kevin
Project Start
1997-05-01
Project End
2009-04-30
Budget Start
2004-05-01
Budget End
2005-04-30
Support Year
14
Fiscal Year
2004
Total Cost
$1,676,766
Indirect Cost
Name
University of Pittsburgh
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Parker, Andrew M; de Bruin, Wändi Bruine; Fischhoff, Baruch et al. (2018) Robustness of Decision-Making Competence: Evidence from two measures and an 11-year longitudinal study. J Behav Decis Mak 31:380-391
Marceau, Kristine; Kirisci, Levent; Tarter, Ralph E (2018) Correspondence of Pubertal Neuroendocrine and Tanner Stage Changes in Boys and Associations With Substance Use. Child Dev :
Vanyukov, Michael M; Nimgaonkar, Vishwajit L; Kirisci, Levent et al. (2018) Association of cognitive function and liability to addiction with childhood herpesvirus infections: A prospective cohort study. Dev Psychopathol 30:143-152
Price, Julia; Drabick, Deborah A G; Ridenour, Ty A (2018) Association With Deviant Peers Across Adolescence: Subtypes, Developmental Patterns, and Long-Term Outcomes. J Clin Child Adolesc Psychol :1-12
Halliburton, Amanda E; Ridenour, Ty A; White, Bradley A et al. (2017) Clinically differentiating life-course-persistent and adolescence-limited conduct problems: Is age-of-onset really enough? J Appl Dev Psychol 52:34-45
Bastian, Jaime R; Chen, Huijun; Zhang, Hongfei et al. (2017) Dose-adjusted plasma concentrations of sublingual buprenorphine are lower during than after pregnancy. Am J Obstet Gynecol 216:64.e1-64.e7
Eckert, Scott; Feingold, Eleanor; Cooper, Margaret et al. (2017) Variants on chromosome 4q21 near PKD2 and SIBLINGs are associated with dental caries. J Hum Genet 62:491-496
Rabinowitz, Jill A; Osigwe, Ijeoma; Byrne, Ashley et al. (2017) Father- and Youth-Reported Family Affective Expression Differentially Predicts Youth Internalizing and Externalizing Symptoms. J Clin Child Adolesc Psychol :1-14
Rabinowitz, Jill A; Osigwe, Ijeoma; Drabick, Deborah A G et al. (2016) Negative emotional reactivity moderates the relations between family cohesion and internalizing and externalizing symptoms in adolescence. J Adolesc 53:116-126
Altszuler, Amy R; Page, Timothy F; Gnagy, Elizabeth M et al. (2016) Financial Dependence of Young Adults with Childhood ADHD. J Abnorm Child Psychol 44:1217-29

Showing the most recent 10 out of 219 publications