Abstract

The Methodology and Statistics Core performs six main tasks essential to achieving the Center's mission. The tasks are: 1) Conduct psychometric analyses of all instruments used in CEDAR to ensure their quality; 2) Evaluate potential threats to the validity of results that could be caused by bias associated with proband ascertainment strategy, cohort effects, protocol implementation, and attrition; 3) Spearhead the development and psychometric analyses of the biobehavioral and environmental constructs contributing to derivation of the substance use disorder (SUD) liability index; 4) Conduct the statistical analyses to test CEDAR's biopsychosocial theory of SUD etiology; 5) Elucidate the relative contribution of the different facets of alcohol, tobacco, other drugs consumption topology in SUD risk and outcome; and, 6) Determine the validity and heuristic utility of quantifying the various DSM diagnostic categories of SUD. These interrelated tasks, requiring extensive synergy among the Center's cores and research modules, constitute essential operational requirements for satisfying CEDAR's mission.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Specialized Center (P50)
Project #
2P50DA005605-14A2
Application #
6722491
Study Section
Special Emphasis Panel (ZDA1-RXL-E (20))
Project Start
2003-12-01
Project End
2008-11-30
Budget Start
2003-12-01
Budget End
2005-04-30
Support Year
14
Fiscal Year
2004
Total Cost
$170,091
Indirect Cost

  Institution

Name
University of Pittsburgh
Department
Type
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

Parker, Andrew M; de Bruin, Wändi Bruine; Fischhoff, Baruch et al. (2018) Robustness of Decision-Making Competence: Evidence from two measures and an 11-year longitudinal study. J Behav Decis Mak 31:380-391
Marceau, Kristine; Kirisci, Levent; Tarter, Ralph E (2018) Correspondence of Pubertal Neuroendocrine and Tanner Stage Changes in Boys and Associations With Substance Use. Child Dev :
Vanyukov, Michael M; Nimgaonkar, Vishwajit L; Kirisci, Levent et al. (2018) Association of cognitive function and liability to addiction with childhood herpesvirus infections: A prospective cohort study. Dev Psychopathol 30:143-152
Price, Julia; Drabick, Deborah A G; Ridenour, Ty A (2018) Association With Deviant Peers Across Adolescence: Subtypes, Developmental Patterns, and Long-Term Outcomes. J Clin Child Adolesc Psychol :1-12
Halliburton, Amanda E; Ridenour, Ty A; White, Bradley A et al. (2017) Clinically differentiating life-course-persistent and adolescence-limited conduct problems: Is age-of-onset really enough? J Appl Dev Psychol 52:34-45
Bastian, Jaime R; Chen, Huijun; Zhang, Hongfei et al. (2017) Dose-adjusted plasma concentrations of sublingual buprenorphine are lower during than after pregnancy. Am J Obstet Gynecol 216:64.e1-64.e7
Eckert, Scott; Feingold, Eleanor; Cooper, Margaret et al. (2017) Variants on chromosome 4q21 near PKD2 and SIBLINGs are associated with dental caries. J Hum Genet 62:491-496
Rabinowitz, Jill A; Osigwe, Ijeoma; Byrne, Ashley et al. (2017) Father- and Youth-Reported Family Affective Expression Differentially Predicts Youth Internalizing and Externalizing Symptoms. J Clin Child Adolesc Psychol :1-14
Rabinowitz, Jill A; Osigwe, Ijeoma; Drabick, Deborah A G et al. (2016) Negative emotional reactivity moderates the relations between family cohesion and internalizing and externalizing symptoms in adolescence. J Adolesc 53:116-126
Altszuler, Amy R; Page, Timothy F; Gnagy, Elizabeth M et al. (2016) Financial Dependence of Young Adults with Childhood ADHD. J Abnorm Child Psychol 44:1217-29

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