Research conducted to date under the Statistics Core has yielded two provisional indexes having discriminant and predictive validity. The Transmissible Liability Index (TLI) and Non-Transmissible Liability Index (NTLl), evaluating the two sources of variance in SUD risk, independently predict diagnosis of cannabis used disorder between ages 10-12 and 22 (TLI OR=2.3;NTLl OR=2.8). Together they predict cannabis use disorder with 75% overall accuracy. These preliminary findings demonstrate the capacity to predict SUD consequent to use of illegal drugs up to 12 years after assessment. Accordingly, the research proposed in the new Translation Module has two overarching objectives. First will be cross-validation of the indexes by rederivation of the indexes using the sample of the Collaborative Studies on the Genetics of Alcoholism [COGA] as well as testing, clarifying, and adjusting for differences between genders, ethnicities, and the samples of the CEDAR and COGA studies. Preliminary correlation between the CEDAR-derived TLI and COGA-derived TLI equaled .98 (the CEDAR TLI had an alpha internal consistency of .74 in the COGA sample), suggesting good generalizability, of the TLI between samples. Cross-validation research will include joining the two indexes for quantification of SUD risk and traditional validity testing. As part of ongoing longitudinal research at CEDAR, this project establishes the foundation to apply etiology findings for selective/indicated SUD prevention. The TLI and NTLl, and their joining into a Resultant Liability Index (RLl), will enable accurate tracking of risk status from late childhood onward for elucidating SUD etiology within an ontogenetic framework. A second main objective of this project is to explicate the factors which intermediate (i.e., mediate or moderate) the relationship between the TLI or NTLl and SUD. To date, over 80 individual and environment latent constructs;that predict cannabis use disorder between childhood and adolescence, and/or discriminate high and low risk youths, have been derived using CEDAR's dataset. In addition to these 80 summative constructs are the manifold observed measures of CEDAR participants (10,000+ items at baseline). Thus, commensurate with selective/indicated prevention, this project will enable accurate detection of high risk youths and will provide guidance for the risks that need to be improved in subsequent intervention, based on the salient intermediary factors empirically linked to SUD etiology. The proposed project will be performed on the CEDAR cohort consisting of 800 families that have been sequentially enrolled for prospective study since 1990. At this juncture, the majority of the sample is passing through the modal period of risk for SUD. Thus, it is opportune (within the Statistics Core) to delineate and scale the transmissible (TLI) and non-transmissible (NTLl) components of SUD liability. It is equally timely (within the Translation Module) to prepare these indexes for applied uses and to delineate the factors that intermediate the TLI and SUD and/or NTLl and SUD to guide prevention strategy. Upon achieving these goals, efficient population screening will be feasible so as to guide selective/indicated prevention.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Specialized Center (P50)
Project #
5P50DA005605-20
Application #
8237023
Study Section
Special Emphasis Panel (ZDA1)
Project Start
Project End
Budget Start
2011-03-01
Budget End
2012-02-29
Support Year
20
Fiscal Year
2011
Total Cost
$58,671
Indirect Cost
Name
University of Pittsburgh
Department
Type
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Halliburton, Amanda E; Ridenour, Ty A; White, Bradley A et al. (2017) Clinically differentiating life-course-persistent and adolescence-limited conduct problems: Is age-of-onset really enough? J Appl Dev Psychol 52:34-45
Bastian, Jaime R; Chen, Huijun; Zhang, Hongfei et al. (2017) Dose-adjusted plasma concentrations of sublingual buprenorphine are lower during than after pregnancy. Am J Obstet Gynecol 216:64.e1-64.e7
Eckert, Scott; Feingold, Eleanor; Cooper, Margaret et al. (2017) Variants on chromosome 4q21 near PKD2 and SIBLINGs are associated with dental caries. J Hum Genet 62:491-496
Harty, Seth C; Gnagy, Elizabeth M; Pelham Jr, William E et al. (2017) Anger-irritability as a mediator of attention deficit hyperactivity disorder risk for adolescent alcohol use and the contribution of coping skills. J Child Psychol Psychiatry 58:555-563
Rabinowitz, Jill A; Osigwe, Ijeoma; Byrne, Ashley et al. (2017) Father- and Youth-Reported Family Affective Expression Differentially Predicts Youth Internalizing and Externalizing Symptoms. J Clin Child Adolesc Psychol :1-14
Rabinowitz, Jill A; Osigwe, Ijeoma; Drabick, Deborah A G et al. (2016) Negative emotional reactivity moderates the relations between family cohesion and internalizing and externalizing symptoms in adolescence. J Adolesc 53:116-126
Vanyukov, Michael M; Tarter, Ralph E; Conway, Kevin P et al. (2016) Risk and resistance perspectives in translation-oriented etiology research. Transl Behav Med 6:44-54
Altszuler, Amy R; Page, Timothy F; Gnagy, Elizabeth M et al. (2016) Financial Dependence of Young Adults with Childhood ADHD. J Abnorm Child Psychol 44:1217-29
Rabinowitz, Jill A; Drabick, Deborah A G; Reynolds, Maureen D et al. (2016) Child Temperamental Flexibility Moderates the Relation between Positive Parenting and Adolescent Adjustment. J Appl Dev Psychol 43:43-53
Molina, Brooke S G; Gnagy, Elizabeth M; Joseph, Heather M et al. (2016) Antisocial Alcoholism in Parents of Adolescents and Young Adults With Childhood ADHD. J Atten Disord :

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