This competing renewal application proposes to continue the follow-up research on 775 families enrolled in the Center's prospective investigations into the etiology of substance use disorder (SUD). The probands are men with lifetime presence/absence of SUD consequent to use of an illicit drug who have a 10-12 year old biological son or daughter. The biological children of SUD men are assigned to the high average risk (HAR) group whereas offspring of men without SUD, having neither axis 1 disorder ("normal") nor SUD psychiatric disorder, are assigned to the low average risk (LAR) groups. These children are currently in varying stages of follow-up evaluation conducted at ages 12-14, 16, 19, and annually thereafter until age 30. We have already shown that we can predict in 10-12 year old youth cannabis use disorder by age 22 with approximately 70% accuracy, thereby substantiating the paradigm, subject recruitment strategy and measurement protocols. Multidisciplinary research is conducted on family members (father, mother, children, step-parents) with the objective of elucidating the genetic, biobehavioral and environmental factors on development of SUD consequent to use of illegal drugs. Research protocols are organized into three thematically connected research modules (Neurogenetics. Developmental Psychopathology, and Translation) linking etiology and prevention. The research components thus align with the NIH Roadmap model such that basic science informs clinical research leading to prevention guided by an understanding of etiology. In addition to module-level research, faculty also participate in 3 centerwide aims: 1) Devise a practical scale to quantify the transmissible liability to SUD;2) Empirically test a biopsychological theory of SUD etiology focusing on off time maturation leading to psychological dysregulation predisposing to SUD;and, 3) Delineate SUD liability variants within an ontogenetic framework. The Center has the program name Center for Education and Drug Abuse Research (CEDAR). It consists of six components (3 cores &3 research modules): 1) Science Administration (R. Tarter, Ph.D.), 2) Clinical Core (J. Cornelius, M.D.), 3) Statistics Core (L. Kirisci, Ph.D.), 4) Neurogenetics Module (M. Vanyukov, Ph.D.) 5) Developmental Psychopathology Module (D. Clark, M.D., Ph.D.), and 6) Translation Module (Ty Ridenour, Ph.D.). Vertical and horizontal integration of the Center's components promote collaborative research encompassing multiple disciplines. To date, this research program has supported over 360 publications, 4 books, and 3 special journal issues as well as the training of numerous students, faculty and fellows. Six K awards are currently funded using CEDAR resources.

Public Health Relevance

This research will contribute to the design and implementation of preventions based on an understanding of etiology of substance use disorder. In addition, instrumentation will be developed for practical use to identify youths who are at high risk for substance use disorder. CENTER CHARACTERISTICS:

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Specialized Center (P50)
Project #
3P50DA005605-22S1
Application #
8699322
Study Section
Special Emphasis Panel (ZDA1-EXL-T (11))
Program Officer
Weinberg, Naimah Z
Project Start
1997-05-01
Project End
2015-02-28
Budget Start
2013-03-01
Budget End
2014-02-28
Support Year
22
Fiscal Year
2013
Total Cost
$99,990
Indirect Cost
$34,423
Name
University of Pittsburgh
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Cochran, Gerald; Gordon, Adam J; Field, Craig et al. (2016) Developing a framework of care for opioid medication misuse in community pharmacy. Res Social Adm Pharm 12:293-301
Babinski, Dara E; Pelham Jr, William E; Molina, Brooke S G et al. (2016) Maternal ADHD, Parenting, and Psychopathology Among Mothers of Adolescents With ADHD. J Atten Disord 20:458-68
Schwantes-An, Tae-Hwi; Zhang, Juan; Chen, Li-Shiun et al. (2016) Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts. Behav Genet 46:151-69
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Altszuler, Amy R; Page, Timothy F; Gnagy, Elizabeth M et al. (2016) Financial Dependence of Young Adults with Childhood ADHD. J Abnorm Child Psychol 44:1217-29
Rabinowitz, Jill A; Osigwe, Ijeoma; Drabick, Deborah A G et al. (2016) Negative emotional reactivity moderates the relations between family cohesion and internalizing and externalizing symptoms in adolescence. J Adolesc 53:116-126
Vanyukov, Michael M; Tarter, Ralph E; Conway, Kevin P et al. (2016) Risk and resistance perspectives in translation-oriented etiology research. Transl Behav Med 6:44-54
Cornelius, Jack R; Chung, Tammy; Douaihy, Antoine B et al. (2016) Mirtazapine in comorbid major depression and an alcohol use disorder: A double-blind placebo-controlled pilot trial. Psychiatry Res 242:326-30
Rabinowitz, Jill A; Drabick, Deborah A G; Reynolds, Maureen D et al. (2016) Child Temperamental Flexibility Moderates the Relation between Positive Parenting and Adolescent Adjustment. J Appl Dev Psychol 43:43-53
Bastian, Jaime R; Chen, Huijun; Zhang, Hongfei et al. (2016) Dose-adjusted plasma concentrations of sublingual buprenorphine are lower during than after pregnancy. Am J Obstet Gynecol :

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