This Medications Development Research Center builds on the strengths and achievements of our existing Center, while developing innovative advances in medications development for opioids, cocaine, marijuana, and one of the (re)emerging drugs of concern, methamphetamine. We have created laboratory models for the initial evaluation of medications and developed procedures for the translation of our laboratory findings to the clinic. The major themes of the Center are: 1) model development, 2) targeted pharmacotherapy, 3) predictors of response, and 4) evaluating medications for emerging problems. The Center consists of 2 Cores and 5 Projects, among which there is considerable synergy and interdependency. Unifying all of the Projects are the Central Administrative Core (Core I) and the Biostatistics, Training and Education Core (Core II). Core I provides administrative and research support including research and nursing staff, clinical services, research facilities, laboratory resources, a centralized and standardized recruitment and screening program, and funding for pilot studies. The Biostatistics component of Core II provides the necessary statistical support for the Center and the Training and Education component of Core II is dedicated to education, training, mentoring in, as evidenced by our successful Substance Abuse Fellowship and extensive education (with our Fellowship program) to medical students, residents, and fellows. Project 1 will evaluate the ability of two glial inhibitors, ibudilast and minocycline, to alter prescription opioid self administration and relapse in humans. Project 2 will assess microglial inhibition for methamphetamine dependence using neuroimaging techniques in non-human primates and humans. Project 3 will employ the brain imaging techniques previously developed in Project 2 to the clinic by combining neuroimaging of dopamine transmission with a randomized clinical trial in cocaine-dependent individuals to evaluate the efficacy of medications that increase synaptic dopamine levels. Similarly, Project 4 will build on previous findings from Project 5 by conducting a randomized clinical trial comparing dronabinol + lofexidine to placebo for the treatment of cannabis dependence. Project 5 will now assess other potential triggers (proximal cues and priming) for marijuana relapse in the laboratory and test medications for each of these triggers. The thematic coherence between the Cores and the Projects is what allows our Center to foster original and creative contributions to the scientific understanding of medications development for drug abuse that is far greater than what could be achieved independently.
This Medications Development Research Center is an integrative endeavor to develop innovative advances in medications development for a range of abused drugs. Our focus is to develop laboratory models to test potential medications and then translate these findings to the clinic. In addition, our Center is dedicated to training and mentoring young researchers and disseminating our research findings to other researchers and the community.
|Cooper, Ziva D; Johnson, Kirk W; Pavlicova, Martina et al. (2016) The effects of ibudilast, a glial activation inhibitor, on opioid withdrawal symptoms in opioid-dependent volunteers. Addict Biol 21:895-903|
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|Jones, Jermaine D; Sullivan, Maria A; Manubay, Jeanne M et al. (2016) The effects of pioglitazone, a PPARÎ³ receptor agonist, on the abuse liability of oxycodone among nondependent opioid users. Physiol Behav 159:33-9|
|Bedi, Gillinder; Shiffrin, Laura; Vadhan, Nehal P et al. (2016) Effects of levodopa-carbidopa-entacapone and smoked cocaine on facial affect recognition in cocaine smokers. J Psychopharmacol 30:370-7|
|Haney, Margaret; Malcolm, Robert J; Babalonis, Shanna et al. (2016) Oral Cannabidiol does not Alter the Subjective, Reinforcing or Cardiovascular Effects of Smoked Cannabis. Neuropsychopharmacology 41:1974-82|
|Levin, Frances R; Mariani, John J; Pavlicova, Martina et al. (2016) Dronabinol and lofexidine for cannabis use disorder: A randomized, double-blind, placebo-controlled trial. Drug Alcohol Depend 159:53-60|
|Cooper, Ziva D; Haney, Margaret (2016) Sex-dependent effects of cannabis-induced analgesia. Drug Alcohol Depend 167:112-20|
|Haney, Margaret; Ramesh, Divya; Glass, Andrew et al. (2015) Naltrexone Maintenance Decreases Cannabis Self-Administration and Subjective Effects in Daily Cannabis Smokers. Neuropsychopharmacology 40:2489-98|
|Dakwar, Elias; Kleber, Herbert D (2015) Naltrexone-facilitated buprenorphine discontinuation: a feasibility trial. J Subst Abuse Treat 53:60-3|
|Askalsky, Paula; Kalapatapu, Raj K; Foltin, Richard W et al. (2015) Butyrylcholinesterase levels and subjective effects of smoked cocaine in healthy cocaine users. Am J Drug Alcohol Abuse 41:161-5|
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