This is a competing continuation of a currently funded Center Grant, """"""""Treatments for Complex Patients in New Settings."""""""" In this continuation the San Francisco Treatment Research Center (hereafter, """"""""Center"""""""") has an integrating focus on continuing and extended models of care. The Center has been productive during the past 5 years, with 190 scientific articles published or in press. The Center structure includes 4 component studies. Component 1 is a health services research study testing an intervention to bring drug abuse continuing care into medical primary care settings, while component 2 is a clinical trial testing an extended care approach to the treatment of tobacco dependence among persons receiving opiate replacement therapy. Components 3 attaches to Component 2 to investigate neurological and neurocognitive substrates of addiction and recovery. Component 4 is a cross-cutting study employing data and participants from both main components (Components 1 and 2) to study prevalence, covariance and change in multiple risk behaviors among persons in continuing care models of treatment, and a secondary analysis studies subgroups of smokers enrolled in drug abuse treatment in order to tailor tobacco dependence treatment to their specific needs. Wrapped around these component studies and providing scientific leadership and infrastructure are a Scientific and Administrative Core and a Statistics and Health Economics Core. Finally, using the Center and its resources as a platform to train and develop new and promising researchers is the Research Training Core. Building on its longstanding and successful research focused on complex patients, the Center innovates by testing continuing care models of treatment to better serve these patients, by increasing its multidisciplinary capabilities to include neurological, neurocognitive and exploratory genetics research, by integrating both treatment research and health services research into the Center's approach, and by testing continuing and extended care models in public health systems as well as in private managed health care systems.

Public Health Relevance

Drug abuse is increasingly recognized as a chronic and relapsing condition, yet there are few practicable approaches to continuing care. This Center will test models of continuing and extended care for drug abuse treatment, including nicotine dependence, and will increase our understanding of how drug-related brain injury affects the process of treatment for, and recovery from, drug abuse. If these continuing care models are found to be effective, they will offer treatment systems practical and effective strategies for longer term and more effective drug abuse treatment. CENTER CHARACTERISTICS:

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Specialized Center (P50)
Project #
5P50DA009253-20
Application #
8668011
Study Section
Special Emphasis Panel (ZDA1-EXL-T (05))
Program Officer
Grossman, Debra
Project Start
1997-09-01
Project End
2015-05-31
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
20
Fiscal Year
2014
Total Cost
$2,494,181
Indirect Cost
$678,423
Name
University of California San Francisco
Department
Psychiatry
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Pagano, Anna; Gubner, Noah R; Le, Thao et al. (2018) Differences in tobacco use prevalence, behaviors, and cessation services by race/ethnicity: A survey of persons in addiction treatment. J Subst Abuse Treat 94:9-17
Vogel, Erin A; Rubinstein, Mark L; Prochaska, Judith J et al. (2018) Associations between marijuana use and tobacco cessation outcomes in young adults. J Subst Abuse Treat 94:69-73
Murray, Donna E; Durazzo, Timothy C; Schmidt, Thomas P et al. (2018) Regional cerebral blood flow in opiate dependence relates to substance use and neuropsychological performance. Addict Biol 23:781-795
Schackman, Bruce R; Gutkind, Sarah; Morgan, Jake R et al. (2018) Cost-effectiveness of hepatitis C screening and treatment linkage intervention in US methadone maintenance treatment programs. Drug Alcohol Depend 185:411-420
Gubner, Noah R; Thrul, Johannes; Kelly, Oona A et al. (2018) Young adults report increased pleasure from smoking cigarettes when drinking alcohol but not when using marijuana. Addict Res Theory 26:71-76
Newville, Howard; Sorensen, James L; Hatch-Maillette, Mary et al. (2018) Temporal Relationship of Sex Risk Behaviors and Substance Use Severity Among Men in Substance Use Treatment. J Sex Res 55:1056-1064
Pagano, Anna; Gubner, Noah; Le, Thao et al. (2018) Cigarette smoking and quit attempts among Latinos in substance use disorder treatment. Am J Drug Alcohol Abuse 44:660-667
Guydish, Joseph; Tajima, Barbara; Le, Thao et al. (2018) Do cigarette graphic warnings encourage smokers to attend a smoking cessation programme: a quasi-experimental study. Tob Control 27:43-49
McKnight, Courtney; Shumway, Martha; Masson, Carmen L et al. (2017) Perceived discrimination among racial and ethnic minority drug users and the association with health care utilization. J Ethn Subst Abuse 16:404-419
Thrul, Johannes; Ramo, Danielle E (2017) Cessation Strategies Young Adult Smokers Use After Participating in a Facebook Intervention. Subst Use Misuse 52:259-264

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