Tailoring programs for substance use and HIV inverventions is critical because the greatest effects will be realized if the right program is offered to the right individuals at the optimal time. At the same time, tailoring programs to each individual in a population may not be feasible. It may be possible, however, to detect a finite set of subgroups of individuals based on common risk exposure, dominant risk effects, treatment response, or mediational pathways;if so, we can leverage preventive intervention resources more effectively by matching appropriate program components to the different subgroups. The overall goals ofthe project are to advance a framework based on finite mixture models and bring it to the forefront in intervention science so that it can be used to address new questions in research on substance use and HIV.
The Specific Aims of this Project are: 1. To enable substance use and HIV scientists to simultaneously (a) identify latent classes of risk and (b) use membership in these latent classes to predict a dependent variable;2. To enable substance use and HIV scientists to identify latent classes characterized by the relations between multiple risks and key dependent variables;3. To enable substance use and HIV scientists to simultaneously (a) identify latent classes characterized by different sizes of treatment effects and (b) use covariates to predict membership in these treatment-response latent classes;4. To enable substance use and HIV scientists to identify latent classes of individuals based on shared mediational pathways;and 5. Dissemination and software development. For each method developed in this project, empirical results will be published in journals focused on prevention/substance use/HIV, and methodological innovations and results of simulation studies will be published in quantitative journals. In addition, by working with the Software Development and Technology Transfer Gore, user-friendly software will be made available for download as SAS procedures and STATA plug-ins for conducting LCA with a dependent variable, LC regression, and LC mediation. Adoption ofthe proposed methods by substance use and HIV scientists in the analysis of empirical diata will inform the development of programs tailored for and targeted to different subgroups of individuals.
This project will enable substance use and HIV scientists to identify underlying subgroups based on risk exposure, dominant risk effects, treatment response, or mediational pathways in order to tailor programs and target them for different subgroups of individuals;this will enhance the effectiveness and efficiency of interventions and ultimately translate to increased public health benefits.
|Kugler, Kari C; Guastaferro, Kate; Shenk, Chad E et al. (2018) The effect of substantiated and unsubstantiated investigations of child maltreatment and subsequent adolescent health. Child Abuse Negl :|
|Smith, Rachel A; MacGeorge, Erina L; Hackman, Nicole M et al. (2018) Campaign Preparation for Complex Initiatives: A Person-Centered Approach to Audience Segmentation of Parents' Antibiotic Stewardship. Health Commun 33:1539-1548|
|Wesche, Rose; Claxton, Shannon E; Lefkowitz, Eva S et al. (2018) Evaluations and Future Plans After Casual Sexual Experiences: Differences Across Partner Type. J Sex Res 55:1180-1191|
|Perzow, Sarah E D; Bray, Bethany C; Wadsworth, Martha E (2018) Financial stress response profiles and psychosocial functioning in low-income parents. J Fam Psychol 32:517-527|
|Smith, Rachel A; Sillars, Alan; Chesnut, Ryan P et al. (2018) Investigating Married Adults' Communal Coping with Genetic Health Risk and Perceived Discrimination. Commun Monogr 85:181-202|
|Bray, Bethany C; Dziak, John J; Patrick, Megan E et al. (2018) Inverse Propensity Score Weighting with a Latent Class Exposure: Estimating the Causal Effect of Reported Reasons for Alcohol Use on Problem Alcohol Use 16 Years Later. Prev Sci :|
|Bediako, Phylicia T; BeLue, Rhonda; Hillemeier, Marianne M (2018) Immigrant Generational Status and Developmental Problems among Prematurely Born Children. J Immigr Minor Health 20:422-430|
|Nahum-Shani, Inbal; Dziak, John J; Collins, Linda M (2018) Multilevel factorial designs with experiment-induced clustering. Psychol Methods 23:458-479|
|Russell, Michael A; Schlomer, Gabriel L; Cleveland, H Harrington et al. (2018) PROSPER Intervention Effects on Adolescents' Alcohol Misuse Vary by GABRA2 Genotype and Age. Prev Sci 19:27-37|
|Reid, Alexander; Halgunseth, Linda C; Espinosa-Hernandez, Graciela et al. (2018) Sociocultural Influences on the Association Between Negative Romantic Experiences and Psychological Maladjustment in Mexican Adolescents. J Res Adolesc 28:888-901|
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