Core C will continue to oversee the execution and development of pilot projects that bring new technologies and new investigators into the Neurobiology of Addiction Research Center (NARC). MUSC neurosciences has undergone dramatic growth within the last 5 years that has expanded the pool of young, talented investigators in preclinical and clincal arenas. The pilot core will provide an opportunity to mentor some of these young investigators into the field of addiction under the supervision of senior NARC investigators. Due to the success of pilot clinical trials during the current funding period Dr. Robert Malcolm has been appointed as co-PL of Core C in order to help recruit and mentor clinical addiction investigators. Preclinical and clinical pilot projects will be solicited by advertisement and word-of-mouth and will be competitvely reviewed by the NARC Internal Steering Committee. Once funded, the progress of projects will undergo extensive monitoring by the Core Director and Clinical co-Director and the Internal Steering Committee. As in the past, the proposed pilot grants will be evaluated and prioritized to promote primarily young investigators whose work will synergize with the overall NARC mission.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Specialized Center (P50)
Project #
5P50DA015369-10
Application #
8377640
Study Section
Special Emphasis Panel (ZDA1-RXL-E)
Project Start
Project End
Budget Start
2012-05-01
Budget End
2013-04-30
Support Year
10
Fiscal Year
2012
Total Cost
$134,183
Indirect Cost
$44,731
Name
Medical University of South Carolina
Department
Type
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29425
Hanlon, Colleen A; Dowdle, Logan T; Gibson, Nicole B et al. (2018) Cortical substrates of cue-reactivity in multiple substance dependent populations: transdiagnostic relevance of the medial prefrontal cortex. Transl Psychiatry 8:186
Roberts-Wolfe, Douglas; Bobadilla, Ana-Clara; Heinsbroek, Jasper A et al. (2018) Drug Refraining and Seeking Potentiate Synapses on Distinct Populations of Accumbens Medium Spiny Neurons. J Neurosci 38:7100-7107
Spencer, Sade; Neuhofer, Daniela; Chioma, Vivian C et al. (2018) A Model of ?9-Tetrahydrocannabinol Self-administration and Reinstatement That Alters Synaptic Plasticity in Nucleus Accumbens. Biol Psychiatry 84:601-610
Parrilla-Carrero, Jeffrey; Buchta, William C; Goswamee, Priyodarshan et al. (2018) Restoration of Kv7 Channel-Mediated Inhibition Reduces Cued-Reinstatement of Cocaine Seeking. J Neurosci 38:4212-4229
Kearney-Ramos, Tonisha E; Lench, Daniel H; Hoffman, Michaela et al. (2018) Gray and white matter integrity influence TMS signal propagation: a multimodal evaluation in cocaine-dependent individuals. Sci Rep 8:3253
Giannotti, Giuseppe; Barry, Sarah M; Siemsen, Ben M et al. (2018) Divergent Prelimbic Cortical Pathways Interact with BDNF to Regulate Cocaine-seeking. J Neurosci 38:8956-8966
Siemsen, Ben M; Lombroso, Paul J; McGinty, Jacqueline F (2018) Intra-prelimbic cortical inhibition of striatal-enriched tyrosine phosphatase suppresses cocaine seeking in rats. Addict Biol 23:219-229
Moorman, David E; James, Morgan H; Kilroy, Elisabeth A et al. (2017) Orexin/hypocretin-1 receptor antagonism reduces ethanol self-administration and reinstatement selectively in highly-motivated rats. Brain Res 1654:34-42
Bobadilla, Ana-Clara; Heinsbroek, Jasper A; Gipson, Cassandra D et al. (2017) Corticostriatal plasticity, neuronal ensembles, and regulation of drug-seeking behavior. Prog Brain Res 235:93-112
Barry, Sarah M; McGinty, Jacqueline F (2017) Role of Src Family Kinases in BDNF-Mediated Suppression of Cocaine-Seeking and Prevention of Cocaine-Induced ERK, GluN2A, and GluN2B Dephosphorylation in the Prelimbic Cortex. Neuropsychopharmacology 42:1972-1980

Showing the most recent 10 out of 180 publications