instrucfions): The Pilot Core will continue to oversee the execution and development of pilot projects that bring new technologies and new investigators into the Neurobiology of Addiction Research Center (NARC). MUSC neurosciences has undergone dramatic growth within the last 5 years that has expanded the pool of young, talented investigators in preclinical and clincal arenas. The pilot core will provide an opportunity to mentor some of these young investigators into the field of addiction under the supervision of senior NARC investigators. Due to the success of preclinical pilot projects and pilot clinical trials during the current funding period, both preclinical and clinical pilot projects will continue to be solicited by advertisement and word-of- mouth, and will be competitvely reviewed by the NARC Internal Steering Committee. Once funded, the progress of projects wlll undergo extensive monitoring by the Core Director and the Steering Committee. As in the past, the proposed pilot grants will be evaluated and prioritized to promote primarily young investigators whose work will synergize with the overall NARC mission. To illustrate the potential ofthe pilot core to assist in the development of young investigators and to promote cutting edge preclinical and clinical research in addiction, the proposal contains possible pilot projects that, if formally submitted in a call for pilot grants, will be considered in a competitive manner if the renewal is funded.

Public Health Relevance

The NARC Pilot Core has an excellent record of mentoring investigators towards research and funding in the neurobiology and pilot clinical trials for addiction. This effort has developed faculty funded through NIDA and NIAAA at MUSC, as well as junior non-tenure track faculty at MUSC finding tenure-track faculty positions outside of MUSC. As such, the Pilot Core is playing an important role in developing the next generation of addiction snienti.qt.q and research clinicians.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Specialized Center (P50)
Project #
2P50DA015369-11
Application #
8585254
Study Section
Special Emphasis Panel (ZDA1-EXL-T (01))
Project Start
Project End
Budget Start
2013-05-15
Budget End
2014-04-30
Support Year
11
Fiscal Year
2013
Total Cost
$147,882
Indirect Cost
$63,174
Name
Medical University of South Carolina
Department
Type
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29425
McClure, Erin A; Baker, Nathaniel L; Gipson, Cassandra D et al. (2015) An open-label pilot trial of N-acetylcysteine and varenicline in adult cigarette smokers. Am J Drug Alcohol Abuse 41:52-6
McGinty, Jacqueline F; Zelek-Molik, Agnieska; Sun, Wei-Lun (2014) Cocaine self-administration causes signaling deficits in corticostriatal circuitry that are reversed by BDNF in early withdrawal. Brain Res :
Scofield, Michael D; Kalivas, Peter W (2014) Astrocytic dysfunction and addiction: consequences of impaired glutamate homeostasis. Neuroscientist 20:610-22
Stankeviciute, Neringa M; Scofield, Michael D; Kalivas, Peter W et al. (2014) Rapid, transient potentiation of dendritic spines in context-induced relapse to cocaine seeking. Addict Biol 19:972-4
McClure, Erin A; Gipson, Cassandra D; Malcolm, Robert J et al. (2014) Potential role of N-acetylcysteine in the management of substance use disorders. CNS Drugs 28:95-106
Mahler, Stephen V; Vazey, Elena M; Beckley, Jacob T et al. (2014) Designer receptors show role for ventral pallidum input to ventral tegmental area in cocaine seeking. Nat Neurosci 17:577-85
Moorman, David E; Aston-Jones, Gary (2014) Orbitofrontal cortical neurons encode expectation-driven initiation of reward-seeking. J Neurosci 34:10234-46
Gipson, Cassandra D; Kupchik, Yonatan M; Kalivas, Peter W (2014) Rapid, transient synaptic plasticity in addiction. Neuropharmacology 76 Pt B:276-86
Sun, Wei-Lun; Coleman, Nortorious T; Zelek-Molik, Agnieszka et al. (2014) Relapse to cocaine-seeking after abstinence is regulated by cAMP-dependent protein kinase A in the prefrontal cortex. Addict Biol 19:77-86
Kalivas, Peter W; Gipson, Cassandra D (2014) "Mourning" a lost opportunity. Psychopharmacology (Berl) 231:3921-2

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