The specific aims of the UW TTURC's Developmental Research Core are to: (1) encourage high quality, innovative tobacco control research; (2) encourage investigators who have not previously worked in the tobacco control realm to engage in transdisciplinary collaborations, and (3) amplify the transdisciplinary research activities of the UW TTURC by expanding research opportunities in the four core studies. Mechanisms are presented for actively soliciting and evaluating developmental research applications from a wide variety of sources and disciplines. For the first year, two developmental research studies are proposed that explore themes of tobacco dependence mechanisms, outcomes and treatment mediators highly relevant to the main research proposals. One study uses emerging affective neuroscience methodologies (instructed fear conditioning, fear-potentiated startle assessments) and biological measures to assess potential mediators of response to bupropion. This study has the potential to reveal treatment outcome predictors including mechanisms not available to self-report. The second study seeks to investigate the population of smokers that would be excluded from both classic randomized clinical trials and effectiveness trials: smokers with significant medical or psychiatric comorbidity (including alcohol and/or other drug dependence). Three hundred such individuals will be recruited for a placebo-controlled treatment study that will assess the treatment success in this underserved population. This study will not only provide important estimates of treatment outcomes in an often-overlooked and under-served population, but will also provide novel information on predictors and mediators of treatment response that may be compared with those found in highly motivated volunteers and primary care patients who smoke.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Specialized Center (P50)
Project #
5P50DA019706-10
Application #
7681551
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2008-09-01
Budget End
2009-08-31
Support Year
10
Fiscal Year
2008
Total Cost
$14,008
Indirect Cost
Name
University of Wisconsin Madison
Department
Type
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Guerreiro, Rita; Ross, Owen A; Kun-Rodrigues, Celia et al. (2018) Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study. Lancet Neurol 17:64-74
Allen, Alicia M; Carlson, Samantha; Eberly, Lynn E et al. (2018) Use of hormonal contraceptives and smoking cessation: A preliminary report. Addict Behav 76:236-242
Deng, Sien; E McCarthy, Danielle; E Piper, Megan et al. (2018) Extreme Response Style and the Measurement of Intra-Individual Variability in Affect. Multivariate Behav Res 53:199-218
Burgess-Hull, Albert J; Roberts, Linda J; Piper, Megan E et al. (2018) The social networks of smokers attempting to quit: An empirically derived and validated classification. Psychol Addict Behav 32:64-75
Glasheen, Cristie; Johnson, Eric O; Saccone, Nancy L et al. (2018) Is the Fagerström test for nicotine dependence invariant across secular trends in smoking? A question for cross-birth cohort analysis of nicotine dependence. Drug Alcohol Depend 185:127-132
Teitelbaum, A M; Murphy, S E; Akk, G et al. (2018) Nicotine dependence is associated with functional variation in FMO3, an enzyme that metabolizes nicotine in the brain. Pharmacogenomics J 18:136-143
Hancock, D B; Guo, Y; Reginsson, G W et al. (2018) Genome-wide association study across European and African American ancestries identifies a SNP in DNMT3B contributing to nicotine dependence. Mol Psychiatry 23:1-9
Singh, Tarjinder; Walters, James T R; Johnstone, Mandy et al. (2017) The contribution of rare variants to risk of schizophrenia in individuals with and without intellectual disability. Nat Genet 49:1167-1173
Peckham-Gregory, Erin C; Chakraborty, Rikhia; Scheurer, Michael E et al. (2017) A genome-wide association study of LCH identifies a variant in SMAD6 associated with susceptibility. Blood 130:2229-2232
Piper, Megan E; Vasilenko, Sara A; Cook, Jessica W et al. (2017) What a difference a day makes: differences in initial abstinence response during a smoking cessation attempt. Addiction 112:330-339

Showing the most recent 10 out of 120 publications