Ensuring the successful development of the next generation of innovative research ideas and young scientists is critical to the continued advancement of high-impact translational science in neuroAIDS and addictions. Building on TMARC's success in supporting pilot studies and junior investigators during the past funding period, we propose to establish a formal Pilot and Developmental (PAD) Core for the renewal. The PAD Core will enable TMARC to expand the scope, rigor, and effectiveness of its already strong investment in serving as a resource-efficient incubator for innovative pilot studies and shaping individually-tailored developmental activities for trainees and junior investigators that will foster their professional growth in neuroAIDS and addictions research. Leadership of the PAD Core is multidisciplinary and brings considerable prior experience in training and the administration of developmental activities. The developmental program will assist trainees and junior investigators in matching with appropriate mentors and accessing TMARC scientific resources. The pilot grant program will involve annual calls for applications, which will Undergo formal scientific review by a nationally-recognized panel of external experts, the resource economy of which will be facilitated by linking the TMARC PAD Core to that of the HIV Neurobehavioral Research Center. After external review, the TMARC scientific leadership will evaluate highly rated proposals for their relevance to the Center's over-arching translational scientific aims and available resources before final funding recommendations are offered to NIDA program staff. In the current application, the PAD Core anticipates proposing 5 novel pilot studies for Year 1 that address issues germane to TMARC's METH/HIV aims, including real-world functioning (ludicello), cerebrovascular imaging (Croteau), social cognition (Sanders), cellular aging (Schrier), and vasculopathy (Soontornniyomkij). Each pilot: a) underwent a rigorous review process;b) is led by a junior investigator;c) has the potential to support external grant applications;and d) leverages the transdisciplinary resources of the Cores and Projects that support it. Abstracts of the Pilot Studies are found in the following pages.

Public Health Relevance

The TMARC PAD Core supports small-scale, innovative studies led by junior scientists that relate to HIV and METH effects on the brain. The PAD Core also for fosters the professional development of promising young scientists. By providing mentorship and multidisciplinary training opportunities, the PAD Core will help foster the next generation of investigators focusing on translational science in HIV and METH

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
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University of California San Diego
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Jones, Jeb; Hoenigl, Martin; Siegler, Aaron J et al. (2017) Assessing the Performance of 3 Human Immunodeficiency Virus Incidence Risk Scores in a Cohort of Black and White Men Who Have Sex With Men in the South. Sex Transm Dis 44:297-302
Osorio, Georgina; Hoenigl, Martin; Quartarolo, Jennifer et al. (2017) Evaluation of opt-out inpatient HIV screening at an urban teaching hospital. AIDS Care 29:1014-1018
Bischoff-Grethe, Amanda; Connolly, Colm G; Jordan, Stephan J et al. (2017) Altered reward expectancy in individuals with recent methamphetamine dependence. J Psychopharmacol 31:17-30
Paolillo, Emily W; Gongvatana, Assawin; Umlauf, Anya et al. (2017) At-Risk Alcohol Use is Associated with Antiretroviral Treatment Nonadherence Among Adults Living with HIV/AIDS. Alcohol Clin Exp Res 41:1518-1525
Hoenigl, Martin; Braun, Dominique L; Kouyos, Roger et al. (2017) Evaluation of the Predictive Potential of the Short Acute Retroviral Syndrome Severity Score for HIV-1 Disease Progression in Individuals With Acute HIV Infection. J Acquir Immune Defic Syndr 74:e114-e117
Woods, Steven Paul; Iudicello, Jennifer E; Morgan, Erin E et al. (2017) Household Everyday Functioning in the Internet Age: Online Shopping and Banking Skills Are Affected in HIV-Associated Neurocognitive Disorders. J Int Neuropsychol Soc 23:605-615
Bortell, Nikki; Basova, Liana; Semenova, Svetlana et al. (2017) Astrocyte-specific overexpressed gene signatures in response to methamphetamine exposure in vitro. J Neuroinflammation 14:49
Kesby, James P; Najera, Julia A; Romoli, Benedetto et al. (2017) HIV-1 TAT protein enhances sensitization to methamphetamine by affecting dopaminergic function. Brain Behav Immun 65:210-221
Sanchez, Ana B; Kaul, Marcus (2017) Neuronal Stress and Injury Caused by HIV-1, cART and Drug Abuse: Converging Contributions to HAND. Brain Sci 7:
Obermeit, Lisa C; Beltran, Jessica; Casaletto, Kaitlin B et al. (2017) Evaluating the accuracy of self-report for the diagnosis of HIV-associated neurocognitive disorder (HAND): defining ""symptomatic"" versus ""asymptomatic"" HAND. J Neurovirol 23:67-78

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