Ensuring the successful development of the next generation of innovative research ideas and young scientists is critical to the continued advancement of high-impact translational science in neuroAIDS and addictions. Building on TMARC's success in supporting pilot studies and junior investigators during the past funding period, we propose to establish a formal Pilot and Developmental (PAD) Core for the renewal. The PAD Core will enable TMARC to expand the scope, rigor, and effectiveness of its already strong investment in serving as a resource-efficient incubator for innovative pilot studies and shaping individually-tailored developmental activities for trainees and junior investigators that will foster their professional growth in neuroAIDS and addictions research. Leadership of the PAD Core is multidisciplinary and brings considerable prior experience in training and the administration of developmental activities. The developmental program will assist trainees and junior investigators in matching with appropriate mentors and accessing TMARC scientific resources. The pilot grant program will involve annual calls for applications, which will Undergo formal scientific review by a nationally-recognized panel of external experts, the resource economy of which will be facilitated by linking the TMARC PAD Core to that of the HIV Neurobehavioral Research Center. After external review, the TMARC scientific leadership will evaluate highly rated proposals for their relevance to the Center's over-arching translational scientific aims and available resources before final funding recommendations are offered to NIDA program staff. In the current application, the PAD Core anticipates proposing 5 novel pilot studies for Year 1 that address issues germane to TMARC's METH/HIV aims, including real-world functioning (ludicello), cerebrovascular imaging (Croteau), social cognition (Sanders), cellular aging (Schrier), and vasculopathy (Soontornniyomkij). Each pilot: a) underwent a rigorous review process;b) is led by a junior investigator;c) has the potential to support external grant applications;and d) leverages the transdisciplinary resources of the Cores and Projects that support it. Abstracts of the Pilot Studies are found in the following pages.

Public Health Relevance

The TMARC PAD Core supports small-scale, innovative studies led by junior scientists that relate to HIV and METH effects on the brain. The PAD Core also for fosters the professional development of promising young scientists. By providing mentorship and multidisciplinary training opportunities, the PAD Core will help foster the next generation of investigators focusing on translational science in HIV and METH

National Institute of Health (NIH)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZDA1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California San Diego
La Jolla
United States
Zip Code
Morgan, Erin E; Iudicello, Jennifer E; Cattie, Jordan E et al. (2015) Neurocognitive impairment is associated with lower health literacy among persons living with HIV infection. AIDS Behav 19:166-77
Casaletto, K B; Obermeit, L; Morgan, E E et al. (2015) Depression and executive dysfunction contribute to a metamemory deficit among individuals with methamphetamine use disorders. Addict Behav 40:45-50
Maung, Ricky; Hoefer, Melanie M; Sanchez, Ana B et al. (2014) CCR5 knockout prevents neuronal injury and behavioral impairment induced in a transgenic mouse model by a CXCR4-using HIV-1 glycoprotein 120. J Immunol 193:1895-910
Morgan, Erin E; Doyle, Katie L; Minassian, Arpi et al. (2014) Elevated intraindividual variability in methamphetamine dependence is associated with poorer everyday functioning. Psychiatry Res 220:527-34
Kamat, Rujvi; Brown, Gregory G; Bolden, Khalima et al. (2014) Apathy is associated with white matter abnormalities in anterior, medial brain regions in persons with HIV infection. J Clin Exp Neuropsychol 36:854-66
Montoya, Jessica L; Georges, Shereen; Poquette, Amelia et al. (2014) Refining a personalized mHealth intervention to promote medication adherence among HIV+ methamphetamine users. AIDS Care 26:1477-81
Desplats, Paula; Dumaop, Wilmar; Cronin, Peter et al. (2014) Epigenetic alterations in the brain associated with HIV-1 infection and methamphetamine dependence. PLoS One 9:e102555
Henry, Brook L; Geyer, Mark A; Buell, Mahalah R et al. (2014) Prepulse inhibition in HIV-1 gp120 transgenic mice after withdrawal from chronic methamphetamine. Behav Pharmacol 25:12-22
Tatro, Erick T; Purnajo, Intan; Richman, Douglas D et al. (2014) Antibody response to Achromobacter xylosoxidans during HIV infection is associated with lower CD4 levels and increased lymphocyte activation. Clin Vaccine Immunol 21:46-50
Iudicello, Jennifer E; Morgan, Erin E; Gongvatana, Assawin et al. (2014) Detrimental impact of remote methamphetamine dependence on neurocognitive and everyday functioning in older but not younger HIV+ adults: evidence for a legacy effect? J Neurovirol 20:85-98

Showing the most recent 10 out of 44 publications