The Recruitment/Screening core will oversee recmitment and screening of eligible participants for all of the human subjects studies of the center (Projects 1-3). To accomplish this goal, we will utilize our established recruitment/screening infrastructure, which comprises: 1) an advertising system entailing television, radio, internet and other media;2) a centralized telephone call answering center that: a) provides initial telephone screening of interested smokers who respond to recruitment advertisements;and b) schedules in-person medical screening sessions;and 3) a physician and three physician assistants covering our four clinical research sites, who conduct physical examinations and additional medical evaluations to implement study inclusion/exclusion criteria. Based on previous experience, this core will be able to recruit, screen and refer to the respective center project approximately 150 participants per year. This participant flow will be more than adequate to help ensure the successful completion of all human studies proposed in this application.
Cigarette smoking is the leading preventable cause of disease and death. These health risks can be reduced substantially by quitting smoking, and yet current smoking cessation treatments have limited effectiveness. By ensuring the adequate recmitment of research participants into the clinical studies of the center, more effective treatments can be developed to aid smokers in the population.
|Rezvani, Amir H; Cauley, Marty C; Levin, Edward D (2014) Lorcaserin, a selective 5-HT(2C) receptor agonist, decreases alcohol intake in female alcohol preferring rats. Pharmacol Biochem Behav 125:8-14|
|Hall, Brandon J; Wells, Corinne; Allenby, Cheyenne et al. (2014) Differential effects of non-nicotine tobacco constituent compounds on nicotine self-administration in rats. Pharmacol Biochem Behav 120:103-8|
|Levin, Edward D; Hao, Ian; Burke, Dennis A et al. (2014) Effects of tobacco smoke constituents, anabasine and anatabine, on memory and attention in female rats. J Psychopharmacol 28:915-22|
|Levin, Edward D (2013) Complex relationships of nicotinic receptor actions and cognitive functions. Biochem Pharmacol 86:1145-52|
|Bough, K J; Lerman, C; Rose, J E et al. (2013) Biomarkers for smoking cessation. Clin Pharmacol Ther 93:526-38|
|Kutlu, Munir G; Burke, Dennis; Slade, Susan et al. (2013) Role of insular cortex Dýýý and Dýýý dopamine receptors in nicotine self-administration in rats. Behav Brain Res 256:273-8|
|Rezvani, Amir H; Sexton, Hannah G; Johnson, Joshua et al. (2013) Effects of caffeine on alcohol consumption and nicotine self-administration in rats. Alcohol Clin Exp Res 37:1609-17|
|Hall, F Scott; Markou, Athina; Levin, Edward D et al. (2012) Mouse models for studying genetic influences on factors determining smoking cessation success in humans. Ann N Y Acad Sci 1248:39-70|
|Levin, Edward D; Slade, Susan; Wells, Corinne et al. (2011) D-cycloserine selectively decreases nicotine self-administration in rats with low baseline levels of response. Pharmacol Biochem Behav 98:210-4|
|Levin, Edward D; Johnson, Joshua E; Slade, Susan et al. (2011) Lorcaserin, a 5-HT2C agonist, decreases nicotine self-administration in female rats. J Pharmacol Exp Ther 338:890-6|