The Recruitment/Screening core will oversee recmitment and screening of eligible participants for all of the human subjects studies of the center (Projects 1-3). To accomplish this goal, we will utilize our established recruitment/screening infrastructure, which comprises: 1) an advertising system entailing television, radio, internet and other media;2) a centralized telephone call answering center that: a) provides initial telephone screening of interested smokers who respond to recruitment advertisements;and b) schedules in-person medical screening sessions;and 3) a physician and three physician assistants covering our four clinical research sites, who conduct physical examinations and additional medical evaluations to implement study inclusion/exclusion criteria. Based on previous experience, this core will be able to recruit, screen and refer to the respective center project approximately 150 participants per year. This participant flow will be more than adequate to help ensure the successful completion of all human studies proposed in this application.

Public Health Relevance

Cigarette smoking is the leading preventable cause of disease and death. These health risks can be reduced substantially by quitting smoking, and yet current smoking cessation treatments have limited effectiveness. By ensuring the adequate recmitment of research participants into the clinical studies of the center, more effective treatments can be developed to aid smokers in the population.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Specialized Center (P50)
Project #
5P50DA027840-04
Application #
8499277
Study Section
Special Emphasis Panel (ZDA1-EXL-T)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
4
Fiscal Year
2013
Total Cost
$122,812
Indirect Cost
$44,588
Name
Duke University
Department
Type
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
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Larrauri, José A; Burke, Dennis A; Hall, Brandon J et al. (2015) Role of nicotinic receptors in the lateral habenula in the attenuation of amphetamine-induced prepulse inhibition deficits of the acoustic startle response in rats. Psychopharmacology (Berl) 232:3009-17
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Walton, Kevin M; Abrams, David B; Bailey, William C et al. (2015) NIH electronic cigarette workshop: developing a research agenda. Nicotine Tob Res 17:259-69
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Levin, Edward D; Wells, Corinne; Johnson, Joshua E et al. (2015) Amitifadine, a triple monoamine re-uptake inhibitor, reduces nicotine self-administration in female rats. Eur J Pharmacol 764:30-7
Hall, Brandon J; Slade, Susan; Wells, Corinne et al. (2015) Bupropion-varenicline interactions and nicotine self-administration behavior in rats. Pharmacol Biochem Behav 130:84-9
Cousins, Vanessa; Rose, Jed E; Levin, Edward D (2014) IV nicotine self-administration in rats using a consummatory operant licking response: sensitivity to serotonergic, glutaminergic and histaminergic drugs. Prog Neuropsychopharmacol Biol Psychiatry 54:200-5
Rose, Jed E; Behm, Frédérique M (2014) Combination treatment with varenicline and bupropion in an adaptive smoking cessation paradigm. Am J Psychiatry 171:1199-205

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