The Administrative Core will serve as the headquarters for the SCOR: Sex Differences and Progesterone Effects on Impulsivity, Smoking, &Cocaine abuse. Drs. Marilyn E. Carroll and Sharon Allen will serve as Co- Directors of the SCOR using a Multiple PI Leadership Plan. The Department of Psychiatry and the Academic Health Center will provide ample space for SCOR staff and the operating procedures. In addition, the Delaware Clinical Research Unit and the Ambulatory Research Center are available for interview and testing space. Administrative Core A will provide the administrative service and coordinate the other Cores, Training and Service (B) and Statistics (C) to benefit the research and training goals of the three projects.

Public Health Relevance

Despite much effort, there are not yet highly effective approved medications for the direct treatment of cocaine and nicotine dependence. This SCOR will carry out interdisciplinary and translational investigations to identify pharmacological interventions targeting behaviors impaired in nicotine and cocaine dependent subjects to enhance the effectiveness of existing behavioral treatments for addiction.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Specialized Center (P50)
Project #
5P50DA033942-03
Application #
8708814
Study Section
Special Emphasis Panel (ZRG1-EMNR-Q)
Project Start
Project End
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
3
Fiscal Year
2014
Total Cost
$98,650
Indirect Cost
$33,749
Name
University of Minnesota Twin Cities
Department
Type
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Allen, Alicia M; McRae-Clark, Aimee L; Carlson, Samantha et al. (2016) Determining menstrual phase in human biobehavioral research: A review with recommendations. Exp Clin Psychopharmacol 24:1-11
Swalve, Natashia; Smethells, John R; Carroll, Marilyn E (2016) Sex differences in the acquisition and maintenance of cocaine and nicotine self-administration in rats. Psychopharmacology (Berl) 233:1005-13
Swalve, Natashia; Smethells, John R; Zlebnik, Natalie E et al. (2016) Sex differences in reinstatement of cocaine-seeking with combination treatments of progesterone and atomoxetine. Pharmacol Biochem Behav 145:17-23
Carroll, Marilyn E; Lynch, Wendy J (2016) How to study sex differences in addiction using animal models. Addict Biol 21:1007-29
Swalve, Natashia; Smethells, John R; Carroll, Marilyn E (2016) Progesterone attenuates impulsive action in a Go/No-Go task for sucrose pellets in female and male rats. Horm Behav 85:43-7
Smethells, John R; Swalve, Natashia L; Eberly, Lynn E et al. (2016) Sex differences in the reduction of impulsive choice (delay discounting) for cocaine in rats with atomoxetine and progesterone. Psychopharmacology (Berl) 233:2999-3008
Smethells, J R; Zlebnik, N E; Miller, D K et al. (2016) Cocaine self-administration and reinstatement in female rats selectively bred for high and low voluntary running. Drug Alcohol Depend 167:163-8
Swalve, Natashia; Smethells, John R; Carroll, Marilyn E (2016) Sex differences in attenuation of nicotine reinstatement after individual and combined treatments of progesterone and varenicline. Behav Brain Res 308:46-52
Lawless, Michael H; Harrison, Katherine A; Grandits, Gregory A et al. (2015) Perceived stress and smoking-related behaviors and symptomatology in male and female smokers. Addict Behav 51:80-3
Weinberger, Andrea H; Smith, Philip H; Allen, Sharon S et al. (2015) Systematic and meta-analytic review of research examining the impact of menstrual cycle phase and ovarian hormones on smoking and cessation. Nicotine Tob Res 17:407-21

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