instmctions): The purpose of the Scientific and Administrative Core is to provide the overall interdisciplinary scientific planning and coordination for the Yale-SCOR as it develops gender-sensitive therapeutics for the treatment of tobacco dependence. Specifically, the Core, through its structure and resources, will: 1) Oversee and facilitate the ongoing conceptual integration of the Yale-SCOR;2) Ensure and support the development of new collaborative research within the Yale-SCOR and with other Yale centers;3) Oversee and monitor centralized training and quality control of core intake assessments across human studies to facilitate the scientific yield across studies;4) Oversee and provide fiscal and administrative management for all components, as well as information on resource allocation and reallocation based on project needs;5) Solicit, review, and fund meritorious applications for pilot projects;and 6) Organize and implement regular planning meetings to facilitate dynamic exchange among investigators regarding new scientific findings and their implications for gender-sensitive medications development. Oversight of all projects and scientific planning will be integrated into this Core rather than distributed across projects, thus facilitating the efficiency ofthe Yale-SCOR. This approach is designed to ensure thatthe Project Pis, investigators, collaborators, and trainees operate in an integrated scientific environment that creates a coordinated interdisciplinary team effort focused on advancing the understanding and development of gender-sensitive smoking interventions. Thus, the Scientific and Administrative Core will be the central organizing force for the Yale-SCOR. This Core will allow the Yale-SCOR to amplify the accomplishments of individual projects. The goals ofthe core will be accomplished through the following specific aims:
AIM 1 : Provide and stimulate integrated scientific research planning among the Yale-SCOR's Principal Investigator, Scientific Director, and Executive Committee, with targeted consultation from the External Scientific Advisory Board;AIIVI 2: Provide and ensure fiscal and administrative oversight to the Yale-SCOR component and pilot projects;
AIM 3 : Maximize the scientific yield across individual studies by utilizing a core battery of methods and assessments and centrally coordinating training in the use of assessments and methods;
AIM 4 : Coordinate planned research and training collaborations and generate new collaborations with other SCORs, existing centers at Yale, and collaborators;
and AIM 5 : Generate interest in and provide pilot project funding for promising new studies on tobacco use and women's health emphasizing treatment development

Public Health Relevance

Women, compared to men have poorer rates of smoking cessation and exacerbated health risk, and appear to have less success with available treatments, yet few attempts have been made to develop gender- sensitive smoking cessation treatments. The Scientific and Administrative Core will advance the public health by providing key infrastructure to support an integrated scientific environment that creates a coordinated interdisciplinary team effort focused on the development of gender-sensitive smoking interventions.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Specialized Center (P50)
Project #
5P50DA033945-02
Application #
8501393
Study Section
Special Emphasis Panel (ZRG1-EMNR-Q)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
2
Fiscal Year
2013
Total Cost
$122,949
Indirect Cost
$73,594
Name
Yale University
Department
Type
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Mineur, Yann S; Einstein, Emily B; Bentham, Matthew P et al. (2015) Expression of the 5-HT1A serotonin receptor in the hippocampus is required for social stress resilience and the antidepressant-like effects induced by the nicotinic partial agonist cytisine. Neuropsychopharmacology 40:938-46
Mazure, Carolyn M; Weinberger, Andrea H; Pittman, Brian et al. (2014) Gender and stress in predicting depressive symptoms following stroke. Cerebrovasc Dis 38:240-6
Higley, Michael J; Picciotto, Marina R (2014) Neuromodulation by acetylcholine: examples from schizophrenia and depression. Curr Opin Neurobiol 29:88-95
Morris, Evan D; Lucas, Molly V; Petrulli, J Ryan et al. (2014) How to design PET experiments to study neurochemistry: application to alcoholism. Yale J Biol Med 87:33-54
Smith, Megan V; Ramsay, Christina; Mazure, Carolyn M (2014) Understanding disparities in subpopulations of women who smoke. Curr Addict Rep 1:69-74
Smith, Philip H; Young-Wolff, Kelly C; Hyland, Andrew et al. (2014) Are statewide restaurant and bar smoking bans associated with reduced cigarette smoking among those with mental illness? Nicotine Tob Res 16:846-54
Mineur, Yann S; Taylor, Seth R; Picciotto, Marina R (2014) Calcineurin downregulation in the amygdala is sufficient to induce anxiety-like and depression-like behaviors in C57BL/6J male mice. Biol Psychiatry 75:991-8
Weinberger, Andrea H; Smith, Philip H; Kaufman, Mira et al. (2014) Consideration of sex in clinical trials of transdermal nicotine patch: a systematic review. Exp Clin Psychopharmacol 22:373-83
Weinberger, Andrea H; Mazure, Carolyn M; McKee, Sherry A et al. (2014) The Association of Tobacco Use and Gender to Cardiac Rehabilitation Outcomes: A Preliminary Investigation. J Subst Use 19:171-175
Smith, Philip H; Mazure, Carolyn M; McKee, Sherry A (2014) Smoking and mental illness in the U.S. population. Tob Control 23:e147-53

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