The two-fold purpose ofthe Service Core is to provide 1) essential research-related services to Yale- SCOR investigators, trainees, and collaborating researchers;and 2) a dedicated resource on emerging gender-sensitive health information on smoking and smoking cessation therapeutics to care providers and consumers at local, regional, and national levels. Efforts of the Service Core will focus on: a) providing expert consultation, management and coordination on/of IRB and clinical regulatory procedures and data safety monitoring, as required for component and pilot projects;b) generating and ensuring comprehensive strategies to recruit representative gender and racial/ethnic minority samples of human subjects into all Yale- SCOR clinical studies;c) maintaining and enhancing modern data management and analytical techniques that are appropriate for addressing our research questions across both preclinical and clinical investigations; d) providing and supporting a structure for training the next generation of researchers, including "clerkships" and other training activities for BIRCWH K12 Scholars and other interested trainees, that ensure involvement in interdisciplinary translational research on sex- and gender-differences to advance women's health with regard to tobacco use;e) engaging healthcare providers and consumers through a variety of print and electronic media - with information for these outlets generated in collaboration with Women's Health Research at Yale;and f) providing scientific and community workshops designed to appeal to a wide audience. The goals of the Service Core will be accomplished through the following specific aims:
AIM 1 : Provide research-related resources to the component and pilot projects (i.e., coordination of all human subject involvement, centralized recruitment, data management, and statistical support for analyses);
AIM 2 : Mentor junior investigators in conducting interdisciplinary translational research on tobacco use and women's health through "clerkships" and other training activities with Yale-SCOR Pis, and pilot funding;
AIM 3 : Translate and disseminate findings generated by our research through the established educational outreach initiatives of Women's Health Research at Yale and the Yale Centerfor Clinical Investigation (YCCI-CTSA);
AIM 4 : Be a national resource to invigorate and galvanize the study of sex and gender differences in relation to smoking by providing expert consultation;supporting faculty training awards;mining national data on gender, smoking and health outcomes to inform health policy;and expanding our current program of local and national community outreach.

Public Health Relevance

Women, compared to men, have poorer rates of smoking cessation and exacerbated health risk from smoking. New gender-sensitive smoking cessation treatments are needed, and gender-specific data on smoking interventions are needed by the public. The Sen/ice Core will contribute to the public health by providing 1) essential research-related services to Yale-SCOR investigators, trainees, and collaborating researchers, and 2) a dedicated resource on emerging gender-sensitive health information on smoking and smoking cessation therapeutics to care providers and consumers.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Specialized Center (P50)
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Special Emphasis Panel (ZRG1-EMNR-Q)
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Yale University
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Mineur, Yann S; Einstein, Emily B; Bentham, Matthew P et al. (2015) Expression of the 5-HT1A serotonin receptor in the hippocampus is required for social stress resilience and the antidepressant-like effects induced by the nicotinic partial agonist cytisine. Neuropsychopharmacology 40:938-46
Mazure, Carolyn M; Weinberger, Andrea H; Pittman, Brian et al. (2014) Gender and stress in predicting depressive symptoms following stroke. Cerebrovasc Dis 38:240-6
Higley, Michael J; Picciotto, Marina R (2014) Neuromodulation by acetylcholine: examples from schizophrenia and depression. Curr Opin Neurobiol 29:88-95
Morris, Evan D; Lucas, Molly V; Petrulli, J Ryan et al. (2014) How to design PET experiments to study neurochemistry: application to alcoholism. Yale J Biol Med 87:33-54
Smith, Megan V; Ramsay, Christina; Mazure, Carolyn M (2014) Understanding disparities in subpopulations of women who smoke. Curr Addict Rep 1:69-74
Smith, Philip H; Young-Wolff, Kelly C; Hyland, Andrew et al. (2014) Are statewide restaurant and bar smoking bans associated with reduced cigarette smoking among those with mental illness? Nicotine Tob Res 16:846-54
Mineur, Yann S; Taylor, Seth R; Picciotto, Marina R (2014) Calcineurin downregulation in the amygdala is sufficient to induce anxiety-like and depression-like behaviors in C57BL/6J male mice. Biol Psychiatry 75:991-8
Weinberger, Andrea H; Smith, Philip H; Kaufman, Mira et al. (2014) Consideration of sex in clinical trials of transdermal nicotine patch: a systematic review. Exp Clin Psychopharmacol 22:373-83
Weinberger, Andrea H; Mazure, Carolyn M; McKee, Sherry A et al. (2014) The Association of Tobacco Use and Gender to Cardiac Rehabilitation Outcomes: A Preliminary Investigation. J Subst Use 19:171-175
Smith, Philip H; Mazure, Carolyn M; McKee, Sherry A (2014) Smoking and mental illness in the U.S. population. Tob Control 23:e147-53

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