Adolescence is widely understood to be a time of both increased risk-taking behavior (RTB) and heightened sensitivity to social contexts. The impact of social context on risk-taking may be especially relevant for early adolescents in the child welfare system (CWS). Early adolescent risk-taking has significant implications for long-term health outcomes, and CWS-involved youth may be particularly vulnerable to social context effects on risk-taking due to histories of peer rejection. The primary goals of the proposed research are threefold. First, we seek to better understand the interactions between risk-taking and social contexts in CWS-involved early adolescents by employing a novel paradigm (validated in our preliminary studies) that includes both behavioral and neuroimaging assessments of RTB across key social contexts: alone, with peers watching, and after social exclusion. Second, we aim to characterize longitudinal associations between neural and behavioral measures of RTB assessed in the laboratory and CWS-involved early adolescent concurrent and subsequent health-risking behaviors (HRBs), including drug use and high-risk sexual behavior, using estimates of brain functioning and connectivity as predictors of real-world outcomes. Third, we aim to explore specific effects of different profiles of adverse childhood experiences (ACEs) on these brain-behavior relationships. Individuals with CWS involvement have high levels of ACEs and high rates of drug abuse and other HIV risk behaviors, as well as related problems, but it is unclear exactly why this is the case. In this investigation, we propose to collect data from CWS-involved youth (N = 150) at two timepoints (age 11-13 and age 13-15 years). At T l we will collect both fMRI and behavioral data on RTB plus self-reports of realworid HRBs, and at T2 we will again collect self-reports of HRBs. In summary, this project will provide a comprehensive understanding of the neural foundations of CWS-involved early adolescent RTB and concurrent/subsequent vulnerability to HRBs associated with specific social contexts and with exposure to early childhood adversity, as well as expand our knowledge about the mechanisms linking childhood adversity with significantly greater engagement in HRBs.

Public Health Relevance

Children in the CWS are among the most disadvantaged individuals in America, with elevated drug use, delinquency, and HIV-risk behaviors. Evidence-based interventions for CWS-involved families are rarely implemented into routine CWS practice. The proposed Center would provide a national resource in drug abuse prevention research, with the ultimate goal of reducing drug use and related outcomes for CWS youth.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Specialized Center (P50)
Project #
5P50DA035763-02
Application #
8693998
Study Section
Special Emphasis Panel (ZDA1-EXL-T)
Project Start
Project End
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
2
Fiscal Year
2014
Total Cost
$530,722
Indirect Cost
Name
Oregon Social Learning Center, Inc.
Department
Type
DUNS #
084418656
City
Eugene
State
OR
Country
United States
Zip Code
97401
Roos, Leslie E; Beauchamp, Kathryn G; Pears, Katherine C et al. (2016) Effects of prenatal substance exposure on neurocognitive correlates of inhibitory control success and failure. Appl Neuropsychol Child :1-12
Fisher, Philip A; Beauchamp, Kate G; Roos, Leslie E et al. (2016) The Neurobiology of Intervention and Prevention in Early Adversity. Annu Rev Clin Psychol 12:331-57
Stover, Carla Smith; Zhou, Yuchun; Kiselica, Andrew et al. (2016) Marital Hostility, Hostile Parenting, and Child Aggression: Associations from Toddlerhood to School Age. J Am Acad Child Adolesc Psychiatry 55:235-42
Clark, Caron A C; Skowron, Elizabeth A; Giuliano, Ryan J et al. (2016) Intersections between cardiac physiology, emotion regulation and interpersonal warmth in preschoolers: Implications for drug abuse prevention from translational neuroscience. Drug Alcohol Depend 163 Suppl 1:S60-9
Saldana, Lisa; Chamberlain, Patricia; Chapman, Jason (2016) A Supervisor-Targeted Implementation Approach to Promote System Change: The R(3) Model. Adm Policy Ment Health :
Gewirtz, Abigail H; DeGarmo, David S; Zamir, Osnat (2016) Effects of a Military Parenting Program on Parental Distress and Suicidal Ideation: After Deployment Adaptive Parenting Tools. Suicide Life Threat Behav 46 Suppl 1:S23-31
Palinkas, Lawrence A; Garcia, Antonio R; Aarons, Gregory A et al. (2016) Measuring Use of Research Evidence: The Structured Interview for Evidence Use. Res Soc Work Pract 26:550-564
Pfeifer, Jennifer H; Allen, Nicholas B (2016) The audacity of specificity: Moving adolescent developmental neuroscience towards more powerful scientific paradigms and translatable models. Dev Cogn Neurosci 17:131-7
Roos, Leslie E; Fisher, Philip A; Shaw, Daniel S et al. (2016) Inherited and environmental influences on a childhood co-occurring symptom phenotype: Evidence from an adoption study. Dev Psychopathol 28:111-25
Chamberlain, Patricia; Feldman, Sara Wolf; Wulczyn, Fred et al. (2016) Implementation and evaluation of linked parenting models in a large urban child welfare system. Child Abuse Negl 53:27-39

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