Abstract

Program Director/Principal Investigator (Last, First, Middle): Khshnan-Sarin, Suchltra/O'Malley, Stephanie S.
SPECIFIC AIMS : The purpose of this Laboratory Core is to support research carried out under the auspices of the proposed Center by providing objective and quantitative estimates of exposure to selected tobacco related drugs /compounds, as reflected by their concentrations in biological fluids. Consistent with one of the priorities in the FOA, the proposed projects are concerned with reducing addiction through better understanding of how , some prevalent modifications in the content of tobacco products may influence risk of addiction to nicotine. Research strategies include administration, by various routes, of nicotine alone, and in conjunction with other selected additives, including menthol, that may influence responses to nicotine. Optimal interpretation of study outcomes requires that variations in nicotine and/or menthol exposure across individuals and experimental arms be considered. The initial list of analyte targets includes nicotine, cotinine, trans 3-OH cotinine/cotinine (OHC/C) ratios, menthol glucuronide and unconjugated menthol (for in-vitro solutions). However, the Laboratory Core^will have the ability to set up other assays as mandated by the evolving needs of the center... General Rationale For An On

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Specialized Center (P50)
Project #
1P50DA036151-01
Application #
8594328
Study Section
Special Emphasis Panel (ZRG1-BDCN-Q (40))
Project Start
Project End
Budget Start
2013-09-30
Budget End
2014-08-31
Support Year
1
Fiscal Year
2013
Total Cost
$349,109
Indirect Cost
$131,587

  Institution

Name
Yale University
Department
Type
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520

  Publications

Simon, Patricia; Camenga, Deepa R; Morean, Meghan E et al. (2018) Socioeconomic status and adolescent e-cigarette use: The mediating role of e-cigarette advertisement exposure. Prev Med 112:193-198
Pittman, Brian; Buta, Eugenia; Krishnan-Sarin, Suchitra et al. (2018) Models for analyzing zero-inflated and overdispersed count data: an application to cigarette and marijuana use. Nicotine Tob Res :
Morean, Meghan E; Krishnan-Sarin, Suchitra; S O'Malley, Stephanie (2018) Assessing nicotine dependence in adolescent E-cigarette users: The 4-item Patient-Reported Outcomes Measurement Information System (PROMIS) Nicotine Dependence Item Bank for electronic cigarettes. Drug Alcohol Depend 188:60-63
Bold, Krysten W; Sussman, Steve; O'Malley, Stephanie S et al. (2018) Measuring E-cigarette dependence: Initial guidance. Addict Behav 79:213-218
Morean, Meghan E; Camenga, Deepa R; Bold, Krysten W et al. (2018) Querying about the Use of Specific E-cigarette Devices May Enhance Accurate Measurement of E-cigarette Prevalence Rates among High School Students. Nicotine Tob Res :
Morean, Meghan E; DeMartini, Kelly S; Foster, Dawn et al. (2018) The Self-Report Habit Index: Assessing habitual marijuana, alcohol, e-cigarette, and cigarette use. Drug Alcohol Depend 186:207-214
Jatlow, Peter; Valentine, Gerald; Gueorguieva, Ralitza et al. (2018) Plasma Menthol Glucuronide as a Biomarker of Acute Menthol Inhalation. Tob Regul Sci 4:586-591
Pentz, Mary Ann; Hieftje, Kimberly D; Pendergrass, Tyra M et al. (2018) A videogame intervention for tobacco product use prevention in adolescents. Addict Behav :
Bold, Krysten W; Krishnan-Sarin, Suchitra; Stoney, Catherine M (2018) E-cigarette use as a potential cardiovascular disease risk behavior. Am Psychol 73:955-967
Maclean, Johanna Catherine; Oney, Melissa; Marti, Joachim et al. (2018) What factors predict the passage of state-level e-cigarette regulations? Health Econ 27:897-907

Showing the most recent 10 out of 67 publications