Program Director/Principal Investigator (Last, First, Middle): Khshnan-Sarin, Suchltra/O'Malley, Stephanie S.
SPECIFIC AIMS : The purpose of this Laboratory Core is to support research carried out under the auspices of the proposed Center by providing objective and quantitative estimates of exposure to selected tobacco related drugs /compounds, as reflected by their concentrations in biological fluids. Consistent with one of the priorities in the FOA, the proposed projects are concerned with reducing addiction through better understanding of how , some prevalent modifications in the content of tobacco products may influence risk of addiction to nicotine. Research strategies include administration, by various routes, of nicotine alone, and in conjunction with other selected additives, including menthol, that may influence responses to nicotine. Optimal interpretation of study outcomes requires that variations in nicotine and/or menthol exposure across individuals and experimental arms be considered. The initial list of analyte targets includes nicotine, cotinine, trans 3-OH cotinine/cotinine (OHC/C) ratios, menthol glucuronide and unconjugated menthol (for in-vitro solutions). However, the Laboratory Core^will have the ability to set up other assays as mandated by the evolving needs of the center... General Rationale For An On

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Specialized Center (P50)
Project #
1P50DA036151-01
Application #
8594328
Study Section
Special Emphasis Panel (ZRG1-BDCN-Q (40))
Project Start
Project End
Budget Start
2013-09-30
Budget End
2014-08-31
Support Year
1
Fiscal Year
2013
Total Cost
$349,109
Indirect Cost
$131,587
Name
Yale University
Department
Type
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Smith, Gregory J; Cichocki, Joseph A; Doughty, Bennett J et al. (2016) Effects of Acetaminophen on Oxidant and Irritant Respiratory Tract Responses to Environmental Tobacco Smoke in Female Mice. Environ Health Perspect 124:642-50
Miao, Shida; Beach, Evan S; Sommer, Toby J et al. (2016) High-Intensity Sweeteners in Alternative Tobacco Products. Nicotine Tob Res :
Morean, Meghan E; Kong, Grace; Camenga, Deepa R et al. (2016) Latent class analysis of current e-cigarette and other substance use in high school students. Drug Alcohol Depend 161:292-7
Camenga, Deepa R; Kong, Grace; Cavallo, Dana A et al. (2016) Current and Former Smokers' Use of Electronic Cigarettes for Quitting Smoking: An Exploratory Study of Adolescents and Young Adults. Nicotine Tob Res :
Valentine, Gerald W; Jatlow, Peter I; Coffman, Marcedes et al. (2016) The effects of alcohol-containing e-cigarettes on young adult smokers. Drug Alcohol Depend 159:272-6
Morean, Meghan E; Kong, Grace; Cavallo, Dana A et al. (2016) Nicotine concentration of e-cigarettes used by adolescents. Drug Alcohol Depend 167:224-7
Hefner, Kathryn; Rosenheck, Robert; Merrel, Jeremy et al. (2016) E-cigarette Use in Veterans Seeking Mental Health and/or Substance Use Services. J Dual Diagn 12:109-17
Ha, Michael A; Smith, Gregory J; Cichocki, Joseph A et al. (2015) Menthol attenuates respiratory irritation and elevates blood cotinine in cigarette smoke exposed mice. PLoS One 10:e0117128
Tanner, Julie-Anne; Novalen, Maria; Jatlow, Peter et al. (2015) Nicotine metabolite ratio (3-hydroxycotinine/cotinine) in plasma and urine by different analytical methods and laboratories: implications for clinical implementation. Cancer Epidemiol Biomarkers Prev 24:1239-46
Addy, Nii A; Nunes, Eric J; Wickham, Robert J (2015) Muscarinic, but not nicotinic, acetylcholine receptor blockade in the ventral tegmental area attenuates cue-induced sucrose-seeking. Behav Brain Res 291:372-6

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