Program Director/Principal Investigator (Last, First, Middle): Khshnan-Sarin, Suchltra/O'Malley, Stephanie S.
SPECIFIC AIMS : The purpose of this Laboratory Core is to support research carried out under the auspices of the proposed Center by providing objective and quantitative estimates of exposure to selected tobacco related drugs /compounds, as reflected by their concentrations in biological fluids. Consistent with one of the priorities in the FOA, the proposed projects are concerned with reducing addiction through better understanding of how , some prevalent modifications in the content of tobacco products may influence risk of addiction to nicotine. Research strategies include administration, by various routes, of nicotine alone, and in conjunction with other selected additives, including menthol, that may influence responses to nicotine. Optimal interpretation of study outcomes requires that variations in nicotine and/or menthol exposure across individuals and experimental arms be considered. The initial list of analyte targets includes nicotine, cotinine, trans 3-OH cotinine/cotinine (OHC/C) ratios, menthol glucuronide and unconjugated menthol (for in-vitro solutions). However, the Laboratory Core will have the ability to set up other assays as mandated by the evolving needs of the center...

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Specialized Center (P50)
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Special Emphasis Panel (ZRG1-BDCN-A)
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Yale University
New Haven
United States
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Krishnan-Sarin, Suchitra; Green, Barry G; Kong, Grace et al. (2017) Studying the interactive effects of menthol and nicotine among youth: An examination using e-cigarettes. Drug Alcohol Depend 180:193-199
Gibson, Laura A; Creamer, MeLisa R; Breland, Alison B et al. (2017) Measuring perceptions related to e-cigarettes: Important principles and next steps to enhance study validity. Addict Behav :
Caceres, Ana I; Liu, Boyi; Jabba, Sairam V et al. (2017) Transient Receptor Potential Cation Channel Subfamily M Member 8 channels mediate the anti-inflammatory effects of eucalyptol. Br J Pharmacol 174:867-879
Baldassarri, Stephen R; Hillmer, Ansel T; Anderson, Jon Mikael et al. (2017) Use of Electronic Cigarettes Leads to Significant Beta2-Nicotinic Acetylcholine Receptor Occupancy: Evidence From a PET Imaging Study. Nicotine Tob Res :
Bold, Krysten W; Kong, Grace; Cavallo, Dana A et al. (2017) E-Cigarette Susceptibility as a Predictor of Youth Initiation of E-Cigarettes. Nicotine Tob Res 20:140-144
Kong, Grace; Unger, Jennifer; Baezconde-Garbanati, Lourdes et al. (2017) The Associations between Yelp Online Reviews and Vape Shops Closing or Remaining Open One Year Later. Tob Prev Cessat 2:
Achanta, Satyanarayana; Jordt, Sven-Eric (2017) TRPA1: Acrolein meets its target. Toxicol Appl Pharmacol 324:45-50
Simon, Patricia; Camenga, Deepa R; Kong, Grace et al. (2017) Youth E-cigarette, Blunt, and Other Tobacco Use Profiles: Does SES Matter? Tob Regul Sci 3:115-127
Kong, Grace; Morean, Meghan E; Cavallo, Dana A et al. (2017) Sources of electronic cigarette acquisition among adolescents in Connecticut. Tob Regul Sci 3:10-16
Bold, Krysten W; Sussman, Steve; O'Malley, Stephanie S et al. (2017) Measuring E-cigarette dependence: Initial guidance. Addict Behav :

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