Program Director/Principal Investigator (Last, First, Middle): Khshnan-Sarin, Suchltra/O'Malley, Stephanie S.
SPECIFIC AIMS : The purpose of this Laboratory Core is to support research carried out under the auspices of the proposed Center by providing objective and quantitative estimates of exposure to selected tobacco related drugs /compounds, as reflected by their concentrations in biological fluids. Consistent with one of the priorities in the FOA, the proposed projects are concerned with reducing addiction through better understanding of how , some prevalent modifications in the content of tobacco products may influence risk of addiction to nicotine. Research strategies include administration, by various routes, of nicotine alone, and in conjunction with other selected additives, including menthol, that may influence responses to nicotine. Optimal interpretation of study outcomes requires that variations in nicotine and/or menthol exposure across individuals and experimental arms be considered. The initial list of analyte targets includes nicotine, cotinine, trans 3-OH cotinine/cotinine (OHC/C) ratios, menthol glucuronide and unconjugated menthol (for in-vitro solutions). However, the Laboratory Core will have the ability to set up other assays as mandated by the evolving needs of the center...

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Specialized Center (P50)
Project #
5P50DA036151-02
Application #
8737869
Study Section
Special Emphasis Panel (ZRG1-BDCN-A)
Project Start
Project End
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
2
Fiscal Year
2014
Total Cost
$327,491
Indirect Cost
$126,731
Name
Yale University
Department
Type
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Morean, Meghan; Krishnan-Sarin, Suchitra; Sussman, Steve et al. (2018) Psychometric evaluation of the Patient-Reported Outcomes Measurement Information System (PROMIS) Nicotine Dependence Item Bank for use with electronic cigarettes. Nicotine Tob Res :
Hefner, Kathryn R; Sollazzo, Antonietta; Mullaney, Sean et al. (2018) E-cigarettes, alcohol use, and mental health: Use and perceptions of e-cigarettes among college students, by alcohol use and mental health status. Addict Behav :
Valentine, Gerald W; Hefner, Kathryn; Jatlow, Peter I et al. (2018) Impact of E-cigarettes on Smoking and Related Outcomes in Veteran Smokers With Psychiatric Comorbidity. J Dual Diagn 14:2-13
Barrington-Trimis, Jessica L; Gibson, Laura A; Halpern-Felsher, Bonnie et al. (2018) Type of E-Cigarette Device Used Among Adolescents and Young Adults: Findings From a Pooled Analysis of Eight Studies of 2166 Vapers. Nicotine Tob Res 20:271-274
Valentine, Gerald W; DeVito, Elise E; Jatlow, Peter I et al. (2018) Acute effects of inhaled menthol on the rewarding effects of intravenous nicotine in smokers. J Psychopharmacol 32:986-994
Garrison, Kathleen A; O'Malley, Stephanie S; Gueorguieva, Ralitza et al. (2018) A fMRI study on the impact of advertising for flavored e-cigarettes on susceptible young adults. Drug Alcohol Depend 186:233-241
Bold, Krysten W; Kong, Grace; Camenga, Deepa R et al. (2018) Trajectories of E-Cigarette and Conventional Cigarette Use Among Youth. Pediatrics 141:
Barrington-Trimis, Jessica L; Kong, Grace; Leventhal, Adam M et al. (2018) E-cigarette Use and Subsequent Smoking Frequency Among Adolescents. Pediatrics 142:
Camenga, Deepa; Gutierrez, Kevin M; Kong, Grace et al. (2018) E-cigarette advertising exposure in e-cigarette naïve adolescents and subsequent e-cigarette use: A longitudinal cohort study. Addict Behav 81:78-83
Kroemer, Nils B; Veldhuizen, Maria G; Delvy, Roberta et al. (2018) Sweet taste potentiates the reinforcing effects of e-cigarettes. Eur Neuropsychopharmacol 28:1089-1102

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