(Core D: Pilot Project Core) The purpose of the Pilot Project Core is to provide resources for follow-up studies that are essential to replicate, validate and extend the results obtained by the center. Follow-up studies may include data collection or analysis. In later years we anticipate conducting follow-up studies in which we produce and phenotype rats with mutations in genes that were identified by our GWAS. Recent advances in the ability to target any gene in the rat genome for deletion (or to produce transgenic overexpressing rats or even knock-ins of putatively causal sequence variants) are one of the key rationales for conducting GWAS in rats. We also hope to use pilot projects to better integrate our findings with emergent findings from human genetic studies. In this section we describe several pilot projects that we would consider for funding and also discuss the mechanism by which we will make decisions about which projects to fund. Pilot project funding will be available to new-, junior-, and senior-level investigators at any of the participating institutions.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZDA1-EXL-T (03))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Chicago
United States
Zip Code
Parker, Clarissa C; Gopalakrishnan, Shyam; Carbonetto, Peter et al. (2016) Genome-wide association study of behavioral, physiological and gene expression traits in outbred CFW mice. Nat Genet 48:919-26
McMurray, K M J; Du, X; Brownlee, M et al. (2016) Neuronal overexpression of Glo1 or amygdalar microinjection of methylglyoxal is sufficient to regulate anxiety-like behavior in mice. Behav Brain Res 301:119-23
King, Christopher P; Palmer, Abraham A; Woods, Leah C Solberg et al. (2016) Premature responding is associated with approach to a food cue in male and female heterogeneous stock rats. Psychopharmacology (Berl) 233:2593-605
Wang, Tengfei; Han, Wenyan; Chen, Hao (2016) Socially acquired nicotine self-administration with an aversive flavor cue in adolescent female rats. Psychopharmacology (Berl) 233:1837-44
Gamazon, Eric R; Wheeler, Heather E; Shah, Kaanan P et al. (2015) A gene-based association method for mapping traits using reference transcriptome data. Nat Genet 47:1091-8
Pitchers, Kyle K; Flagel, Shelly B; O'Donnell, Elizabeth G et al. (2015) Individual variation in the propensity to attribute incentive salience to a food cue: influence of sex. Behav Brain Res 278:462-9
Wang, T; Han, W; Wang, B et al. (2014) Propensity for social interaction predicts nicotine-reinforced behaviors in outbred rats. Genes Brain Behav 13:202-12
Parker, Clarissa C; Chen, Hao; Flagel, Shelly B et al. (2014) Rats are the smart choice: Rationale for a renewed focus on rats in behavioral genetics. Neuropharmacology 76 Pt B:250-8