(Core D: Pilot Project Core) The purpose of the Pilot Project Core is to provide resources for follow-up studies that are essential to replicate, validate and extend the results obtained by the center. Follow-up studies may include data collection or analysis. In later years we anticipate conducting follow-up studies in which we produce and phenotype rats with mutations in genes that were identified by our GWAS. Recent advances in the ability to target any gene in the rat genome for deletion (or to produce transgenic overexpressing rats or even knock-ins of putatively causal sequence variants) are one of the key rationales for conducting GWAS in rats. We also hope to use pilot projects to better integrate our findings with emergent findings from human genetic studies. In this section we describe several pilot projects that we would consider for funding and also discuss the mechanism by which we will make decisions about which projects to fund. Pilot project funding will be available to new-, junior-, and senior-level investigators at any of the participating institutions.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Specialized Center (P50)
Project #
1P50DA037844-01
Application #
8742618
Study Section
Special Emphasis Panel (ZDA1-EXL-T (03))
Project Start
Project End
Budget Start
2014-06-15
Budget End
2015-04-30
Support Year
1
Fiscal Year
2014
Total Cost
$189,597
Indirect Cost
$69,599
Name
University of Chicago
Department
Type
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
Holl, K; He, H; Wedemeyer, M et al. (2018) Heterogeneous stock rats: a model to study the genetics of despair-like behavior in adolescence. Genes Brain Behav 17:139-148
Sanchez-Roige, Sandra; Palmer, Abraham A; Fontanillas, Pierre et al. (2018) Genome-Wide Association Study Meta-Analysis of the Alcohol Use Disorders Identification Test (AUDIT) in Two Population-Based Cohorts. Am J Psychiatry :appiajp201818040369
Turner, Cortney A; Flagel, Shelly B; Blandino Jr, Peter et al. (2017) Utilizing a unique animal model to better understand human temperament. Curr Opin Behav Sci 14:108-114
Flagel, Shelly B; Robinson, Terry E (2017) Neurobiological Basis of Individual Variation in Stimulus-Reward Learning. Curr Opin Behav Sci 13:178-185
Tripi, Jordan A; Dent, Micheal L; Meyer, Paul J (2017) Individual differences in food cue responsivity are associated with acute and repeated cocaine-induced vocalizations, but not cue-induced vocalizations. Psychopharmacology (Berl) 234:437-446
King, C P; Militello, L; Hart, A et al. (2017) Cdh13 and AdipoQ gene knockout alter instrumental and Pavlovian drug conditioning. Genes Brain Behav 16:686-698
Koshy Cherian, Ajeesh; Kucinski, Aaron; Pitchers, Kyle et al. (2017) Unresponsive Choline Transporter as a Trait Neuromarker and a Causal Mediator of Bottom-Up Attentional Biases. J Neurosci 37:2947-2959
Woods, Leah C Solberg; Mott, Richard (2017) Heterogeneous Stock Populations for Analysis of Complex Traits. Methods Mol Biol 1488:31-44
Parker, Clarissa C; Gopalakrishnan, Shyam; Carbonetto, Peter et al. (2016) Genome-wide association study of behavioral, physiological and gene expression traits in outbred CFW mice. Nat Genet 48:919-26
King, Christopher P; Palmer, Abraham A; Woods, Leah C Solberg et al. (2016) Premature responding is associated with approach to a food cue in male and female heterogeneous stock rats. Psychopharmacology (Berl) 233:2593-605

Showing the most recent 10 out of 16 publications