This competing renewal application requests continuation of clinical and basic research evaluating different cochlear implant prostheses. Ninety- five postlingual profoundly deaf adults implanted with 3 different multichannel prostheses will be engaged in a within-subject clinical trial of speech processing strategies. Secondly, 45 prelingually profoundly deaf children (2-13 years of age) will be implanted with multichannel cochlear implants to determine if the age at implantation affects outcome. This collaborative effort involves five areas of investigation: audiology, psychology, aural rehabilitation, electrophysiology, and speech production. Audiologic performance will be evaluated after brief and long-term experience with either analogue or interleaved pulsatile speech processing algorithms using MiniMed and lnerald cochlear implants. Nucleus users will participate in a trial contrasting two speech processing strategies. Psychological studies will evaluate the behavioral and emotional consequences of cochlear implants in both adults and children. Psychological variables that may be predictive implant use will be assessed. The adult Aural Rehabilitation Project will determine differences between rehabilitation approaches and assess the importance of communication strategies. The relationship between intraoperative measures of cochlear nerve action potentials and performance with an implant will be explored in an electrophysiologic project. Animal studies will be used to correlate electrophysiologic measures and morphology of the peripheral auditory system. A children's aural rehabilitation and speech production project will assess the relative contribution of age and home-based rehabilitation to outcome. The overall objectives of the research program include: 1) optimize speech coding algorithms for individual subjects to reduce performance variability; 2) develop electrophysiologic and psychologic measures predictive of outcome; 3) provide long-term follow-up of multichannel implant recipients; 4) assess the impact of implant coding strategies and audiovisual training on communication functioning; 5) measure the utility for methods of enhancing performance of multichannel cochlear implants in prelingually deafened children and determine the effect of age at implantation.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Specialized Center (P50)
Project #
5P50DC000242-09
Application #
3105549
Study Section
Communication Disorders Review Committee (CDRC)
Project Start
1985-09-09
Project End
1995-08-31
Budget Start
1993-09-01
Budget End
1994-08-31
Support Year
9
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of Iowa
Department
Type
Schools of Medicine
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Wu, Yu-Hsiang; Stangl, Elizabeth; Chipara, Octav et al. (2018) Characteristics of Real-World Signal to Noise Ratios and Speech Listening Situations of Older Adults With Mild to Moderate Hearing Loss. Ear Hear 39:293-304
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Kim, Jeong-Seo; Tejani, Viral D; Abbas, Paul J et al. (2018) Postoperative Electrocochleography from Hybrid Cochlear Implant users: An Alternative Analysis Procedure. Hear Res 370:304-315
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Bonnard, Damien; Schwalje, Adam; Gantz, Bruce et al. (2018) Electric and acoustic harmonic integration predicts speech-in-noise performance in hybrid cochlear implant users. Hear Res 367:223-230
Pimperton, Hannah; Walker, Elizabeth A (2018) Word Learning in Children With Cochlear Implants: Examining Performance Relative to Hearing Peers and Relations With Age at Implantation. Ear Hear 39:980-991
McMurray, Bob; Ellis, Tyler P; Apfelbaum, Keith S (2018) How Do You Deal With Uncertainty? Cochlear Implant Users Differ in the Dynamics of Lexical Processing of Noncanonical Inputs. Ear Hear :
McMurray, Bob; Danelz, Ani; Rigler, Hannah et al. (2018) Speech categorization develops slowly through adolescence. Dev Psychol 54:1472-1491
Klein, Kelsey E; Wu, Yu-Hsiang; Stangl, Elizabeth et al. (2018) Using a Digital Language Processor to Quantify the Auditory Environment and the Effect of Hearing Aids for Adults with Hearing Loss. J Am Acad Audiol 29:279-291
Roembke, Tanja C; Wiggs, Kelsey K; McMurray, Bob (2018) Symbolic flexibility during unsupervised word learning in children and adults. J Exp Child Psychol 175:17-36

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