Project 1: Acoustic Plus Electric Hearing Preservation of residual acoustic hearing during cochlear implantation has become an important improvement in the performance of cochlear implants. Not only does it improve the performance of implants (particularly for noisy, real-world listening conditions) but also allows the treatment of patients with severe high-frequency hearing loss, who have substantial low-frequency hearing. This project proposes to continue this work on combining acoustic plus electric (A+E) hearing. In addition to the overall goal of improving patient care for hearing loss, several unique research opportunities arise from this work. The first opportunity arises because of the new population of patients that will be implanted with these A+E devices. Never before have patients with such high levels of pre-operative residual hearing been implanted in such a large- scale project. We are at the same time seeing levels of performance for the transmission of speech through the short electrode that are surprising in light of the previous literature. This will allow us to re-examine some of the commonly held beliefs about the limitations of electric stimulation due to channel interaction. The second opportunity arises because the short-electrode Hybrid implant assigns low- and mid-frequency speech bands to extreme basal locations in the cochlea. Thus we have a unique opportunity to study the effects of remapping, neural plasticity, and adaptation to highly-distorted place-frequency maps in the cochlea.

Public Health Relevance

This research has the potential to continue to influence clinical practice. The new populations of patients will be implanted with hearing preservation devices will allow us to potentially expand the performance ceilings for all cochlear implants. The knowledge we gain regarding adapting to these new hearing preservation electrodes will influence the designs of implants in the future as well.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Specialized Center (P50)
Project #
5P50DC000242-28
Application #
8606842
Study Section
Special Emphasis Panel (ZDC1-SRB-L)
Project Start
Project End
Budget Start
2014-02-01
Budget End
2015-01-31
Support Year
28
Fiscal Year
2014
Total Cost
$206,145
Indirect Cost
$67,345
Name
University of Iowa
Department
Type
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Walker, Elizabeth; McCreery, Ryan; Spratford, Meredith et al. (2016) Children with Auditory Neuropathy Spectrum Disorder Fitted with Hearing Aids Applying the American Academy of Audiology Pediatric Amplification Guideline: Current Practice and Outcomes. J Am Acad Audiol 27:204-18
Rhone, Ariane E; Nourski, Kirill V; Oya, Hiroyuki et al. (2016) Can you hear me yet? An intracranial investigation of speech and non-speech audiovisual interactions in human cortex. Lang Cogn Neurosci 31:284-302
Shibata, Seiji B; Ranum, Paul T; Moteki, Hideaki et al. (2016) RNA Interference Prevents Autosomal-Dominant Hearing Loss. Am J Hum Genet 98:1101-13
Gantz, Bruce J; Dunn, Camille; Oleson, Jacob et al. (2016) Multicenter clinical trial of the Nucleus Hybrid S8 cochlear implant: Final outcomes. Laryngoscope 126:962-73
Gantz, Bruce J; Dunn, Camille; Walker, Elizabeth et al. (2016) Outcomes of Adolescents With a Short Electrode Cochlear Implant With Preserved Residual Hearing. Otol Neurotol 37:e118-25
McMurray, Bob; Jongman, Allard (2016) What Comes After /f/? Prediction in Speech Derives From Data-Explanatory Processes. Psychol Sci 27:43-52
Gfeller, K (2016) Music-based training for pediatric CI recipients: A systematic analysis of published studies. Eur Ann Otorhinolaryngol Head Neck Dis 133 Suppl 1:S50-6
Roland Jr, J Thomas; Gantz, Bruce J; Waltzman, Susan B et al. (2016) United States multicenter clinical trial of the cochlear nucleus hybrid implant system. Laryngoscope 126:175-81
Roembke, Tanja; McMurray, Bob (2016) Observational Word Learning: Beyond Propose-But-Verify and Associative Bean Counting. J Mem Lang 87:105-127
Kashio, Akinori; Tejani, Viral D; Scheperle, Rachel A et al. (2016) Exploring the Source of Neural Responses of Different Latencies Obtained from Different Recording Electrodes in Cochlear Implant Users. Audiol Neurootol 21:141-9

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