The primary functions of the Human Subjects Core are as follows. (1) Recruitment of human subjects from majority and minority populations for participation in the longitudinal study of age-related hearing loss and in experiments proposed in each project. (2) Collection, storage, and analysis of demographic, audiologic, and biologic/medical data and tissue (blood and DMA) from human subjects enrolling in and continuing in the longitudinal study. These data define the basic demographic, audiologic, and medical profiles of each subject and are organized into searchable databases, which provide key information needed by investigators in each project to select subjects according to the needs of their experiments. (3) Coordination of subject schedules for the audiologic and medical test battery, annual evaluations, longitudinal measures, and visits to the Otolaryngology clinic and to the General Clinical Research Center (GCRC). Because of the strong links among projects, there is substantial overlap of needs for subject participation across projects. Thus, a major function of the Human Subjects Core is to make efficient use of subjects' testing time.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Specialized Center (P50)
Project #
5P50DC000422-25
Application #
8378531
Study Section
Special Emphasis Panel (ZDC1-SRB-S)
Project Start
Project End
2013-12-31
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
25
Fiscal Year
2012
Total Cost
$621,172
Indirect Cost
$200,037
Name
Medical University of South Carolina
Department
Type
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29425
Eckert, Mark A; Vaden Jr, Kenneth I; Teubner-Rhodes, Susan et al. (2017) A Novel Communication Value Task Demonstrates Evidence of Response Bias in Cases with Presbyacusis. Sci Rep 7:16512
Harris, Kelly C; Dubno, Judy R (2017) Age-related deficits in auditory temporal processing: unique contributions of neural dyssynchrony and slowed neuronal processing. Neurobiol Aging 53:150-158
Harris, Kelly C; Vaden Jr, Kenneth I; McClaskey, Carolyn M et al. (2017) Complementary metrics of human auditory nerve function derived from compound action potentials. J Neurophysiol :jn.00638.2017
Eckert, Mark A; Matthews, Lois J; Dubno, Judy R (2017) Self-Assessed Hearing Handicap in Older Adults With Poorer-Than-Predicted Speech Recognition in Noise. J Speech Lang Hear Res 60:251-262
Vaden Jr, Kenneth I; Teubner-Rhodes, Susan; Ahlstrom, Jayne B et al. (2017) Cingulo-opercular activity affects incidental memory encoding for speech in noise. Neuroimage 157:381-387
Vaden Jr, Kenneth I; Matthews, Lois J; Eckert, Mark A et al. (2017) Longitudinal Changes in Audiometric Phenotypes of Age-Related Hearing Loss. J Assoc Res Otolaryngol 18:371-385
Teubner-Rhodes, Susan; Vaden Jr, Kenneth I; Dubno, Judy R et al. (2017) Cognitive persistence: Development and validation of a novel measure from the Wisconsin Card Sorting Test. Neuropsychologia 102:95-108
McRackan, Theodore R; Ahlstrom, Jayne B; Clinkscales, William B et al. (2016) Clinical Implications of Word Recognition Differences in Earphone and Aided Conditions. Otol Neurotol 37:1475-1481
Jennings, Skyler G; Ahlstrom, Jayne B; Dubno, Judy R (2016) Effects of age and hearing loss on overshoot. J Acoust Soc Am 140:2481
Tekin, Demet; Yan, Denise; Bademci, Guney et al. (2016) A next-generation sequencing gene panel (MiamiOtoGenes) for comprehensive analysis of deafness genes. Hear Res 333:179-184

Showing the most recent 10 out of 120 publications