Age-related declines in hearing and speech recognition are growing public health concerns that have a profound impact on the ability to communicate. Older adults describe speech recognition as fatiguing and experience speech recognition declines even after accounting for audibility, suggesting that central nervous system (CNS) declines affect speech recognition. The neuroimaging experiments proposed in Project 2 examine effects of presbyacusis and aging on central auditory and attention systems that support speech recognition.
Aim 2. 1 uses novel structural imaging to test the hypothesis that unique patterns of brain structure occur with unique audiometric patterns of presbyacusis.
This aim i s designed to characterize the extent to which 1) high frequency hearing loss occurs with trans-synaptic degeneration that stems from sensory hair cell loss, while 2) low frequency hearing loss occurs with vascular disease that is hypothesized to underlie metabolic presbyacusis.
Aim 2. 2 involves functional imaging and manipulations of attention systems to test the hypothesis that attention-related systems support speech recognition in older adults with hearing loss.
This aim i s designed to provide a mechanistic explanation for why word recognition can be better or worse than expected for hearing loss based on the engagement of specific attention systems.
Aim 2. 3 involves structural and functional imaging to test the hypothesis that longitudinal speech recognition changes occur with additive structural declines in auditory and attention-related cortex.
This aim i s designed to identify neural systems exhibiting changes that track with declines in speech recognition during a time period when auditory thresholds are relatively stable. Thus, Project 2 characterizes the unique impacts of declines in auditory thresholds and age on speech recognition, is an extension of Project 1's focus on age related changes in the auditory periphery, and will provide in vivo evidence to support mechanisms for hearing loss that are studied in Projects 3 and 4. Our overarching goal is to characterize 1) CNS declines in older adults that negatively affect speech recognition and 2) preserved structure and function that support speech recognition, thereby guiding efforts to improve communication and enhance the quality of life for older adults.

Public Health Relevance

Hearing loss and communication deficits are a major and growing problem among older adults for which treatments have limited effectiveness. We focus this project, and our program as a whole, on understanding the reasons for age-related hearing loss and speech recognition declines so that more effective treatments can be developed that address the multiple reasons for communication declines.

National Institute of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
Specialized Center (P50)
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Special Emphasis Panel (ZDC1-SRB-K (15))
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Medical University of South Carolina
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Ben Said, Mariem; Grati, M'hamed; Ishimoto, Takahiro et al. (2016) A mutation in SLC22A4 encoding an organic cation transporter expressed in the cochlea strial endothelium causes human recessive non-syndromic hearing loss DFNB60. Hum Genet 135:513-24
Simpson, Annie N; Simpson, Kit N; Dubno, Judy R (2016) Higher Health Care Costs in Middle-aged US Adults With Hearing Loss. JAMA Otolaryngol Head Neck Surg 142:607-9
Kuchinsky, Stefanie E; Vaden Jr, Kenneth I; Ahlstrom, Jayne B et al. (2016) Task-Related Vigilance During Word Recognition in Noise for Older Adults with Hearing Loss. Exp Aging Res 42:50-66
Fogerty, Daniel; Ahlstrom, Jayne B; Bologna, William J et al. (2016) Glimpsing Speech in the Presence of Nonsimultaneous Amplitude Modulations From a Competing Talker: Effect of Modulation Rate, Age, and Hearing Loss. J Speech Lang Hear Res 59:1198-1207
Tekin, Demet; Yan, Denise; Bademci, Guney et al. (2016) A next-generation sequencing gene panel (MiamiOtoGenes) for comprehensive analysis of deafness genes. Hear Res 333:179-84
Svec, Adam; Dubno, Judy R; Nelson, Peggy B (2016) Inherent envelope fluctuations in forward maskers: Effects of masker-probe delay for listeners with normal and impaired hearing. J Acoust Soc Am 139:1195-203
Lang, Hainan; Nishimoto, Eishi; Xing, Yazhi et al. (2016) Contributions of Mouse and Human Hematopoietic Cells to Remodeling of the Adult Auditory Nerve After Neuron Loss. Mol Ther 24:2000-2011
Vaden Jr, Kenneth I; Kuchinsky, Stefanie E; Ahlstrom, Jayne B et al. (2016) Cingulo-Opercular Function During Word Recognition in Noise for Older Adults with Hearing Loss. Exp Aging Res 42:67-82
Vaden Jr, Kenneth I; Matthews, Lois J; Eckert, Mark A et al. (2016) Longitudinal Changes in Audiometric Phenotypes of Age-Related Hearing Loss. J Assoc Res Otolaryngol :
Jennings, Skyler G; Ahlstrom, Jayne B; Dubno, Judy R (2016) Effects of age and hearing loss on overshoot. J Acoust Soc Am 140:2481

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