Age-related declines in hearing and speech recognition are growing public health concerns that have a profound impact on the ability to communicate. Older adults describe speech recognition as fatiguing and experience speech recognition declines even after accounting for audibility, suggesting that central nervous system (CNS) declines affect speech recognition. The neuroimaging experiments proposed in Project 2 examine effects of presbyacusis and aging on central auditory and attention systems that support speech recognition.
Aim 2. 1 uses novel structural imaging to test the hypothesis that unique patterns of brain structure occur with unique audiometric patterns of presbyacusis.
This aim i s designed to characterize the extent to which 1) high frequency hearing loss occurs with trans-synaptic degeneration that stems from sensory hair cell loss, while 2) low frequency hearing loss occurs with vascular disease that is hypothesized to underlie metabolic presbyacusis.
Aim 2. 2 involves functional imaging and manipulations of attention systems to test the hypothesis that attention-related systems support speech recognition in older adults with hearing loss.
This aim i s designed to provide a mechanistic explanation for why word recognition can be better or worse than expected for hearing loss based on the engagement of specific attention systems.
Aim 2. 3 involves structural and functional imaging to test the hypothesis that longitudinal speech recognition changes occur with additive structural declines in auditory and attention-related cortex.
This aim i s designed to identify neural systems exhibiting changes that track with declines in speech recognition during a time period when auditory thresholds are relatively stable. Thus, Project 2 characterizes the unique impacts of declines in auditory thresholds and age on speech recognition, is an extension of Project 1's focus on age related changes in the auditory periphery, and will provide in vivo evidence to support mechanisms for hearing loss that are studied in Projects 3 and 4. Our overarching goal is to characterize 1) CNS declines in older adults that negatively affect speech recognition and 2) preserved structure and function that support speech recognition, thereby guiding efforts to improve communication and enhance the quality of life for older adults.

Public Health Relevance

Hearing loss and communication deficits are a major and growing problem among older adults for which treatments have limited effectiveness. We focus this project, and our program as a whole, on understanding the reasons for age-related hearing loss and speech recognition declines so that more effective treatments can be developed that address the multiple reasons for communication declines.

National Institute of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
Specialized Center (P50)
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Special Emphasis Panel (ZDC1-SRB-K (15))
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Medical University of South Carolina
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Eckert, Mark A; Vaden Jr, Kenneth I; Teubner-Rhodes, Susan et al. (2017) A Novel Communication Value Task Demonstrates Evidence of Response Bias in Cases with Presbyacusis. Sci Rep 7:16512
Harris, Kelly C; Dubno, Judy R (2017) Age-related deficits in auditory temporal processing: unique contributions of neural dyssynchrony and slowed neuronal processing. Neurobiol Aging 53:150-158
Harris, Kelly C; Vaden Jr, Kenneth I; McClaskey, Carolyn M et al. (2017) Complementary metrics of human auditory nerve function derived from compound action potentials. J Neurophysiol :jn.00638.2017
Eckert, Mark A; Matthews, Lois J; Dubno, Judy R (2017) Self-Assessed Hearing Handicap in Older Adults With Poorer-Than-Predicted Speech Recognition in Noise. J Speech Lang Hear Res 60:251-262
Vaden Jr, Kenneth I; Teubner-Rhodes, Susan; Ahlstrom, Jayne B et al. (2017) Cingulo-opercular activity affects incidental memory encoding for speech in noise. Neuroimage 157:381-387
Vaden Jr, Kenneth I; Matthews, Lois J; Eckert, Mark A et al. (2017) Longitudinal Changes in Audiometric Phenotypes of Age-Related Hearing Loss. J Assoc Res Otolaryngol 18:371-385
Teubner-Rhodes, Susan; Vaden Jr, Kenneth I; Dubno, Judy R et al. (2017) Cognitive persistence: Development and validation of a novel measure from the Wisconsin Card Sorting Test. Neuropsychologia 102:95-108
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Jennings, Skyler G; Ahlstrom, Jayne B; Dubno, Judy R (2016) Effects of age and hearing loss on overshoot. J Acoust Soc Am 140:2481
Tekin, Demet; Yan, Denise; Bademci, Guney et al. (2016) A next-generation sequencing gene panel (MiamiOtoGenes) for comprehensive analysis of deafness genes. Hear Res 333:179-184

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