The Clinical Research Center is supported by two Cores. Core A is the administrative core, which provides administrative support for scheduling subjects and handles purchasing, accounting, and general administrative functions for all projects. Core B is the Human Subjects Core where the primary functions are (1) the recruitment of human subjects for participation in the longitudinal study of age-related hearing loss and in experiments proposed in Projects 1-4;(2) collection, storage, and analysis of demographic, audiologic, and biologic/medical data and tissue (blood and DNA) from subjects enrolling in and continuing in the longitudinal study, which covers the past 25 years and the next five years;and (3) coordination of subject schedules for the audiologic and medical test battery, annual evaluations, and longitudinal measures. A goal of the Human Subjects Core is to make efficient use of subjects'testing time and coordinate storage of their data to optimize data access and analyses across projects. The Human Subjects Core is fundamental to the Clinical Research Center, with each of the four scientific projects drawing from and contributing to the human subject database. These cross-sectional and longitudinal data provide a rich and detailed characterization of the changes that occur in the aging peripheral and central auditory systems, which will further define and validate phenotypes of age-related hearing loss and assist in the generation of hypotheses and interpretation of experimental results in all projects.
Age-related hearing loss is a current and growing public health concern that affects communication and quality of life of millions of older adults. The Cores support the administration of the Clinical Research Center and provide key data to meet the goals of developing new diagnostic tests and discovering new methods for prevention and treatment of this high-prevalence communication disorder.
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|Simpson, Annie N; Simpson, Kit N; Dubno, Judy R (2016) Higher Health Care Costs in Middle-aged US Adults With Hearing Loss. JAMA Otolaryngol Head Neck Surg 142:607-9|
|Kuchinsky, Stefanie E; Vaden Jr, Kenneth I; Ahlstrom, Jayne B et al. (2016) Task-Related Vigilance During Word Recognition in Noise for Older Adults with Hearing Loss. Exp Aging Res 42:50-66|
|Fogerty, Daniel; Ahlstrom, Jayne B; Bologna, William J et al. (2016) Glimpsing Speech in the Presence of Nonsimultaneous Amplitude Modulations From a Competing Talker: Effect of Modulation Rate, Age, and Hearing Loss. J Speech Lang Hear Res 59:1198-1207|
|Tekin, Demet; Yan, Denise; Bademci, Guney et al. (2016) A next-generation sequencing gene panel (MiamiOtoGenes) for comprehensive analysis of deafness genes. Hear Res 333:179-84|
|Svec, Adam; Dubno, Judy R; Nelson, Peggy B (2016) Inherent envelope fluctuations in forward maskers: Effects of masker-probe delay for listeners with normal and impaired hearing. J Acoust Soc Am 139:1195-203|
|Lang, Hainan; Nishimoto, Eishi; Xing, Yazhi et al. (2016) Contributions of Mouse and Human Hematopoietic Cells to Remodeling of the Adult Auditory Nerve After Neuron Loss. Mol Ther 24:2000-2011|
|Vaden Jr, Kenneth I; Kuchinsky, Stefanie E; Ahlstrom, Jayne B et al. (2016) Cingulo-Opercular Function During Word Recognition in Noise for Older Adults with Hearing Loss. Exp Aging Res 42:67-82|
|Vaden Jr, Kenneth I; Matthews, Lois J; Eckert, Mark A et al. (2016) Longitudinal Changes in Audiometric Phenotypes of Age-Related Hearing Loss. J Assoc Res Otolaryngol :|
|Jennings, Skyler G; Ahlstrom, Jayne B; Dubno, Judy R (2016) Effects of age and hearing loss on overshoot. J Acoust Soc Am 140:2481|
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