The Clinical Research Center is supported by two Cores. Core A is the administrative core, which provides administrative support for scheduling subjects and handles purchasing, accounting, and general administrative functions for all projects. Core B is the Human Subjects Core where the primary functions are (1) the recruitment of human subjects for participation in the longitudinal study of age-related hearing loss and in experiments proposed in Projects 1-4;(2) collection, storage, and analysis of demographic, audiologic, and biologic/medical data and tissue (blood and DNA) from subjects enrolling in and continuing in the longitudinal study, which covers the past 25 years and the next five years;and (3) coordination of subject schedules for the audiologic and medical test battery, annual evaluations, and longitudinal measures. A goal of the Human Subjects Core is to make efficient use of subjects'testing time and coordinate storage of their data to optimize data access and analyses across projects. The Human Subjects Core is fundamental to the Clinical Research Center, with each of the four scientific projects drawing from and contributing to the human subject database. These cross-sectional and longitudinal data provide a rich and detailed characterization of the changes that occur in the aging peripheral and central auditory systems, which will further define and validate phenotypes of age-related hearing loss and assist in the generation of hypotheses and interpretation of experimental results in all projects.

Public Health Relevance

Age-related hearing loss is a current and growing public health concern that affects communication and quality of life of millions of older adults. The Cores support the administration of the Clinical Research Center and provide key data to meet the goals of developing new diagnostic tests and discovering new methods for prevention and treatment of this high-prevalence communication disorder.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Specialized Center (P50)
Project #
2P50DC000422-26
Application #
8782525
Study Section
Special Emphasis Panel (ZDC1-SRB-K (15))
Project Start
Project End
Budget Start
2014-01-01
Budget End
2014-12-31
Support Year
26
Fiscal Year
2014
Total Cost
$99,450
Indirect Cost
$32,928
Name
Medical University of South Carolina
Department
Type
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29425
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Harris, Kelly C; Dubno, Judy R (2017) Age-related deficits in auditory temporal processing: unique contributions of neural dyssynchrony and slowed neuronal processing. Neurobiol Aging 53:150-158
Harris, Kelly C; Vaden Jr, Kenneth I; McClaskey, Carolyn M et al. (2017) Complementary metrics of human auditory nerve function derived from compound action potentials. J Neurophysiol :jn.00638.2017
Eckert, Mark A; Matthews, Lois J; Dubno, Judy R (2017) Self-Assessed Hearing Handicap in Older Adults With Poorer-Than-Predicted Speech Recognition in Noise. J Speech Lang Hear Res 60:251-262
Vaden Jr, Kenneth I; Teubner-Rhodes, Susan; Ahlstrom, Jayne B et al. (2017) Cingulo-opercular activity affects incidental memory encoding for speech in noise. Neuroimage 157:381-387
Vaden Jr, Kenneth I; Matthews, Lois J; Eckert, Mark A et al. (2017) Longitudinal Changes in Audiometric Phenotypes of Age-Related Hearing Loss. J Assoc Res Otolaryngol 18:371-385
Teubner-Rhodes, Susan; Vaden Jr, Kenneth I; Dubno, Judy R et al. (2017) Cognitive persistence: Development and validation of a novel measure from the Wisconsin Card Sorting Test. Neuropsychologia 102:95-108
McRackan, Theodore R; Ahlstrom, Jayne B; Clinkscales, William B et al. (2016) Clinical Implications of Word Recognition Differences in Earphone and Aided Conditions. Otol Neurotol 37:1475-1481
Jennings, Skyler G; Ahlstrom, Jayne B; Dubno, Judy R (2016) Effects of age and hearing loss on overshoot. J Acoust Soc Am 140:2481
Tekin, Demet; Yan, Denise; Bademci, Guney et al. (2016) A next-generation sequencing gene panel (MiamiOtoGenes) for comprehensive analysis of deafness genes. Hear Res 333:179-184

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