The primary functions of the Human Subjects Core are as follows. (1) Recruitment of female and male human subjects representing the population of the local community for participation In the longitudinal study of age-related hearing loss and experiments proposed in each project. (2) Collection, storage, and analysis of demographic, audiologic, and biologic/medical data and tissue (blood and DNA) from human subjects enrolling in and continuing in the longitudinal study. These data define the basic demographic, audiologic, and medical profiles of each subject and are organized into a searchable database, which provides key information needed by investigators in each project to select subjects according to the needs of their experiments. (3) Coordination of subject schedules for the audiologic and medical test battery, annual evaluations, longitudinal measures, and visits to the Otolaryngology clinic and to the Clinical Translational Research Center (CTRC) for blood draws. Because of the strong links among projects, there is substantial overlap of needs for subject participation. Thus, a major goal ofthe Human Subjects Core is to make efficient use of subjects'testing time and coordinate storage of their data to optimize data access and analyses across projects.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Specialized Center (P50)
Project #
2P50DC000422-26
Application #
8782526
Study Section
Special Emphasis Panel (ZDC1-SRB-K (15))
Project Start
Project End
Budget Start
2014-01-01
Budget End
2014-12-31
Support Year
26
Fiscal Year
2014
Total Cost
$535,718
Indirect Cost
$177,378
Name
Medical University of South Carolina
Department
Type
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29425
Harris, Kelly C; Vaden Jr, Kenneth I; Dubno, Judy R (2014) Auditory-evoked cortical activity: contribution of brain noise, phase locking, and spectral power. J Basic Clin Physiol Pharmacol 25:277-84
Hao, Xinping; Xing, Yazhi; Moore, Michael W et al. (2014) Sox10 expressing cells in the lateral wall of the aged mouse and human cochlea. PLoS One 9:e97389
Jennings, Skyler G; Ahlstrom, Jayne B; Dubno, Judy R (2014) Computational modeling of individual differences in behavioral estimates of cochlear nonlinearities. J Assoc Res Otolaryngol 15:945-60
Kuchinsky, Stefanie E; Ahlstrom, Jayne B; Cute, Stephanie L et al. (2014) Speech-perception training for older adults with hearing loss impacts word recognition and effort. Psychophysiology 51:1046-57
Stevens, Shawn M; Xing, Yazhi; Hensley, Christopher T et al. (2014) Heptanol application to the mouse round window: a model for studying cochlear lateral wall regeneration. Otolaryngol Head Neck Surg 150:659-65
Chintanpalli, Ananthakrishna; Ahlstrom, Jayne B; Dubno, Judy R (2014) Computational model predictions of cues for concurrent vowel identification. J Assoc Res Otolaryngol 15:823-37
Ahlstrom, Jayne B; Horwitz, Amy R; Dubno, Judy R (2014) Spatial separation benefit for unaided and aided listening. Ear Hear 35:72-85
Yuan, Yasheng; Shi, Fuxin; Yin, Yanbo et al. (2014) Ouabain-induced cochlear nerve degeneration: synaptic loss and plasticity in a mouse model of auditory neuropathy. J Assoc Res Otolaryngol 15:31-43
Veneman, Carrie E; Gordon-Salant, Sandra; Matthews, Lois J et al. (2013) Age and measurement time-of-day effects on speech recognition in noise. Ear Hear 34:288-99
Bologna, William J; Chatterjee, Monita; Dubno, Judy R (2013) Perceived listening effort for a tonal task with contralateral competing signals. J Acoust Soc Am 134:EL352-8

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