Although up to 30% of individuals with ASD are minimally verbal, extremely few interventions can reliably produce significant improvements in speech output. Recently, our laboratory has developed Auditory-Motor Mapping Training (AMMT), a novel intonation-based intervention, which aims to facilitate speech output in minimally verbal children with ASD. This intervention involves the mapping of sounds to oral articulatory actions through intonation and bimanual motor activities. AMMT is built upon the musical strengths and preferences that have been observed in these children. Furthermore, associating sounds with actions engages an auditory-motor network of brain regions important for speech that has been reported to be dysfunctional in ASD. The overall aim of the study is to compare the efficacy of AMMT to that of a control therapy (CT) in facilitating speech output in a randomized controlled trial (RCT). To examine whether the core components of AMMT are responsible for the treatment effects, CT will omit the intonation and motor components. The accuracy of each child's speech output will be assessed multiple times before, during, and after treatment by independent coders. Our overall aim will also be complemented by two additional aims, in which we will examine whether frequency of AMMT affects treatment outcome, and whether pre-existing variability in language-related pathways and functional connections correlate with outcome, and is changed after treatment. Based on our preliminary data, we hypothesize that: (1) compared to CT, AMMT will result in significantly greater improvements in the accuracy of consonant and vowel productions, with generalization to items that are not trained during the therapy,and more appropriate words after therapy, (2) greater improvements will be observed in individuals who undergo higher frequency (compared to lower frequency) of AMMT, (3) baseline behavioral measures (e.g., cognitive, speech praxis, joint attention abilities) will be related to the degree of speech improvements in both AMMT and CT, and (4) the degree of variability infunctional and structural brain connections will be related to AMMT treatment outcome, and (5) intensive AMMT treatment will lead to increased functional connections in the auditory-motor network. By using a combination of behavioral and brain imaging measures, the proposed study will examine the efficacy of a novel intervention, and enhance our understanding of the underlying neural mechanisms that underlie the therapy effects.
One characteristic of ASD, perhaps the most heartbreaking, us the deficiency in communication skills. Unfortunately, interventions aimed at improving verbal output and communication skills are relatively few and have had limited success. Since children with ASD often respond to music better than to spoken language, and enjoy engaging in music making, methods that use intonation-based activities may provide an effective alternative intervention strategy to facilitate speech and communication skills.
|Chenausky, Karen; Norton, Andrea; Tager-Flusberg, Helen et al. (2018) Behavioral predictors of improved speech output in minimally verbal children with autism. Autism Res 11:1356-1365|
|Kleckner, Ian R; Jones, Rebecca M; Wilder-Smith, Oliver et al. (2018) Simple, Transparent, and Flexible Automated Quality Assessment Procedures for Ambulatory Electrodermal Activity Data. IEEE Trans Biomed Eng 65:1460-1467|
|Chenausky, Karen V; Schlaug, Gottfried (2018) From intuition to intervention: developing an intonation-based treatment for autism. Ann N Y Acad Sci :|
|Goodwin, Matthew S; Özdenizci, Ozan; Cumpanasoiu, Catalina et al. (2018) Predicting Imminent Aggression Onset in Minimally-Verbal Youth with Autism Spectrum Disorder Using Preceding Physiological Signals. Int Conf Pervasive Comput Technol Healthc 2018:201-207|
|Schwartz, Sophie; Shinn-Cunningham, Barbara; Tager-Flusberg, Helen (2018) Meta-analysis and systematic review of the literature characterizing auditory mismatch negativity in individuals with autism. Neurosci Biobehav Rev 87:106-117|
|Karahano?lu, Fikret I??k; Baran, Bengi; Nguyen, Quynh Trang Huong et al. (2018) Diffusion-weighted imaging evidence of altered white matter development from late childhood to early adulthood in Autism Spectrum Disorder. Neuroimage Clin 19:840-847|
|Großekathöfer, Ulf; Manyakov, Nikolay V; Mihajlovi?, Vojkan et al. (2017) Automated Detection of Stereotypical Motor Movements in Autism Spectrum Disorder Using Recurrence Quantification Analysis. Front Neuroinform 11:9|
|Chenausky, Karen V; Norton, Andrea C; Schlaug, Gottfried (2017) Auditory-Motor Mapping Training in a More Verbal Child with Autism. Front Hum Neurosci 11:426|
|Palumbo, Richard V; Marraccini, Marisa E; Weyandt, Lisa L et al. (2017) Interpersonal Autonomic Physiology: A Systematic Review of the Literature. Pers Soc Psychol Rev 21:99-141|
|Fedorenko, Evelina; Morgan, Angela; Murray, Elizabeth et al. (2016) A highly penetrant form of childhood apraxia of speech due to deletion of 16p11.2. Eur J Hum Genet 24:302-6|
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