A Developmental Research Program (DRP) is proposed for this Head and Neck SPORE to attract new ideas and pilot studies within and outside of our institution. The process for advertising pilot funds, evaluation and periodic review and funding of a spectrum of pilot projects is described. There is a focused abstract describing the proposed pilots as well as subsequent progress and publications from the work once it has been carried out. Promoting pilot projects with translational research potential to full projects within the SPORE is a key area of focus and investment for us. As presented here, several pilots were promoted to full research projects and have become the basis of 3 of the 5 new projects in this cycle. We provide information on outcome of these pilots including success in the competition for outside funds. Collaborations between projects and other SPOREs is also described.

National Institute of Health (NIH)
National Institute of Dental & Craniofacial Research (NIDCR)
Specialized Center (P50)
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Special Emphasis Panel (ZCA1-RPRB-7 (M1))
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Johns Hopkins University
United States
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Guo, Theresa; Sakai, Akihiro; Afsari, Bahman et al. (2017) A Novel Functional Splice Variant of AKT3 Defined by Analysis of Alternative Splice Expression in HPV-Positive Oropharyngeal Cancers. Cancer Res 77:5248-5258
Kang, Hyunseok; Tan, Marietta; Bishop, Justin A et al. (2017) Whole-Exome Sequencing of Salivary Gland Mucoepidermoid Carcinoma. Clin Cancer Res 23:283-288
Bishop, Justin A; Westra, William H (2017) MYB Translocation Status in Salivary Gland Epithelial-Myoepithelial Carcinoma: Evaluation of Classic, Variant, and Hybrid Forms. Am J Surg Pathol :
Zhang, Hongzheng; Kim, Sungjin; Chen, Zhengjia et al. (2017) Prognostic biomarkers in patients with human immunodeficiency virus-positive disease with head and neck squamous cell carcinoma. Head Neck 39:2433-2443
Bishop, Justin A; Rooper, Lisa M; Chiosea, Simion I et al. (2017) Clear Cell Carcinoma of Salivary Glands is Frequently p16 Positive: A Pitfall in the Interpretation of Oropharyngeal Biopsies. Am J Surg Pathol :
Anagnostou, Valsamo; Smith, Kellie N; Forde, Patrick M et al. (2017) Evolution of Neoantigen Landscape during Immune Checkpoint Blockade in Non-Small Cell Lung Cancer. Cancer Discov 7:264-276
Walline, Heather M; Carey, Thomas E; Goudsmit, Christine M et al. (2017) High-Risk HPV, Biomarkers, and Outcome in Matched Cohorts of Head and Neck Cancer Patients Positive and Negative for HIV. Mol Cancer Res 15:179-188
Peri, Suraj; Izumchenko, Evgeny; Schubert, Adrian D et al. (2017) NSD1- and NSD2-damaging mutations define a subset of laryngeal tumors with favorable prognosis. Nat Commun 8:1772
Weidhaas, Joanne B; Harris, Jonathan; Schaue, Dörthe et al. (2017) The KRAS-Variant and Cetuximab Response in Head and Neck Squamous Cell Cancer: A Secondary Analysis of a Randomized Clinical Trial. JAMA Oncol 3:483-491
Guerrero-Preston, Rafael; White, James Robert; Godoy-Vitorino, Filipa et al. (2017) High-resolution microbiome profiling uncovers Fusobacterium nucleatum, Lactobacillus gasseri/johnsonii, and Lactobacillus vaginalis associated to oral and oropharyngeal cancer in saliva from HPV positive and HPV negative patients treated with surgery and Oncotarget 8:110931-110948

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