The proposed project is a case-control study designed to investigate the role of site, gender and race in human papillomavirus (HPV) -positive head and neck squamous cell cancer (HNSCC). HPV is an established etiologic agent in a subset of HNSCCs which largely arise from the oropharynx and is an independent marker of improved prognosis. It appears to be responsible for a shifting epidemiology: oropharyngeal cancer is rapidly rising and is projected to overtake cervical cancer. Men and Whites bear the disproportionate burden of HPV-positive HNSCCs. Reasons for this unique demographic distribution are pooriy understood. Given the strong associations of HPV-HNSCC with sexual behaviors, we will explore if gender- and race- related differences in behaviors (sexual, tobacco and alcohol) may in part be responsible for these demographic pattems. We will also investigate whether gender- and racial- differences in immunologic response are driving these distinct demographic pattems. In addition, it is presently unknown how often HPV causes malignancy in non-oropharyngeal squamous cell cancers, despite the potential therapeutic implications. Therefore, the aims of this proposal are to 1) explore the relative etiologic roles of tumor HPV, tobacco, alcohol and drug use, on odds of non-oropharyngeal site head and neck squamous cell cancer, 2) determine gender differences in risk factors for HPV-HNSCC compared to age, gender, and race matched non-cancer controls and 3) evaluate differences in risk factors for oropharyngeal cancer In black and white patients compared to age, gender, and race matched non-cancer controls.

Public Health Relevance

This proposal will inform us how often HPV-HNSCC occurs at head and neck sites other than the oropharynx and why whites and males are more commonly affected than blacks and females. This knowledge will have implications for both preventive and therapeutic vaccinations, identification of high-risk populations for potential screening and addressing public health education campaigns.

National Institute of Health (NIH)
National Institute of Dental & Craniofacial Research (NIDCR)
Specialized Center (P50)
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Special Emphasis Panel (ZCA1-RPRB-7)
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Johns Hopkins University
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Thompson, Elizabeth D; Stelow, Edward B; Mills, Stacey E et al. (2016) Large Cell Neuroendocrine Carcinoma of the Head and Neck: A Clinicopathologic Series of 10 Cases With an Emphasis on HPV Status. Am J Surg Pathol 40:471-8
Guo, Theresa; Rettig, Eleni; Fakhry, Carole (2016) Understanding the impact of survival and human papillomavirus tumor status on timing of recurrence in oropharyngeal squamous cell carcinoma. Oral Oncol 52:97-103
Stansfield, John C; Rusay, Matthew; Shan, Roger et al. (2016) Toward Signaling-Driven Biomarkers Immune to Normal Tissue Contamination. Cancer Inform 15:15-21
Kang, Hyunseok; Tan, Marietta; Bishop, Justin A et al. (2016) Whole-Exome Sequencing of Salivary Gland Mucoepidermoid Carcinoma. Clin Cancer Res :
Motz, Kevin; Qualliotine, Jesse R; Rettig, Eleni et al. (2016) Changes in Unknown Primary Squamous Cell Carcinoma of the Head and Neck at Initial Presentation in the Era of Human Papillomavirus. JAMA Otolaryngol Head Neck Surg 142:223-8
Guo, Theresa; Eisele, David W; Fakhry, Carole (2016) The potential impact of prophylactic human papillomavirus vaccination on oropharyngeal cancer. Cancer 122:2313-23
Walline, Heather M; Carey, Thomas E; Goudsmit, Christine M et al. (2016) High-Risk HPV, Biomarkers, and Outcome in Matched Cohorts of Head and Neck Cancer Patients Positive and Negative for HIV. Mol Cancer Res :
Rettig, Eleni M; Talbot Jr, C Conover; Sausen, Mark et al. (2016) Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma. Cancer Prev Res (Phila) 9:265-74
Sun, Yun-Yan; Peng, Shiwen; Han, Liping et al. (2016) Local HPV Recombinant Vaccinia Boost Following Priming with an HPV DNA Vaccine Enhances Local HPV-Specific CD8+ T-cell-Mediated Tumor Control in the Genital Tract. Clin Cancer Res 22:657-69
Fakhry, Carole; Qualliotine, Jesse R; Zhang, Zhe et al. (2016) Serum Antibodies to HPV16 Early Proteins Warrant Investigation as Potential Biomarkers for Risk Stratification and Recurrence of HPV-Associated Oropharyngeal Cancer. Cancer Prev Res (Phila) 9:135-41

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