The proposed project is a case-control study designed to investigate the role of site, gender and race in human papillomavirus (HPV) -positive head and neck squamous cell cancer (HNSCC). HPV is an established etiologic agent in a subset of HNSCCs which largely arise from the oropharynx and is an independent marker of improved prognosis. It appears to be responsible for a shifting epidemiology: oropharyngeal cancer is rapidly rising and is projected to overtake cervical cancer. Men and Whites bear the disproportionate burden of HPV-positive HNSCCs. Reasons for this unique demographic distribution are pooriy understood. Given the strong associations of HPV-HNSCC with sexual behaviors, we will explore if gender- and race- related differences in behaviors (sexual, tobacco and alcohol) may in part be responsible for these demographic pattems. We will also investigate whether gender- and racial- differences in immunologic response are driving these distinct demographic pattems. In addition, it is presently unknown how often HPV causes malignancy in non-oropharyngeal squamous cell cancers, despite the potential therapeutic implications. Therefore, the aims of this proposal are to 1) explore the relative etiologic roles of tumor HPV, tobacco, alcohol and drug use, on odds of non-oropharyngeal site head and neck squamous cell cancer, 2) determine gender differences in risk factors for HPV-HNSCC compared to age, gender, and race matched non-cancer controls and 3) evaluate differences in risk factors for oropharyngeal cancer In black and white patients compared to age, gender, and race matched non-cancer controls.

Public Health Relevance

This proposal will inform us how often HPV-HNSCC occurs at head and neck sites other than the oropharynx and why whites and males are more commonly affected than blacks and females. This knowledge will have implications for both preventive and therapeutic vaccinations, identification of high-risk populations for potential screening and addressing public health education campaigns.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Specialized Center (P50)
Project #
5P50DE019032-12
Application #
8529492
Study Section
Special Emphasis Panel (ZCA1-RPRB-7)
Project Start
Project End
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
12
Fiscal Year
2013
Total Cost
$395,398
Indirect Cost
$142,179
Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
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Fakhry, Carole; Qualliotine, Jesse R; Zhang, Zhe et al. (2016) Serum Antibodies to HPV16 Early Proteins Warrant Investigation as Potential Biomarkers for Risk Stratification and Recurrence of HPV-Associated Oropharyngeal Cancer. Cancer Prev Res (Phila) 9:135-41

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