Symptomatic urinary stone disease affects approximately 900,000 persons in the United States each year, resulting in an estimated annual medical cost of $4.5 billion. Computed tomography (CT) is the established method for imaging urinary calculi and can provide accurate sub-millimeter details of the size and location of renal stones. However, in clinical routine, even the most modern CT system cannot reliably determine stone composition or quantify the amount of stone material. Our long term goal is to use advanced CT methodologies to quantitate the morphology and composition of urinary calculi for the purpose of directing clinical treatment and facilitating clinical investigation. We plan to use available and evolving technology to reliably detect the smallest possible stones and/or stone precursor plaques. Our objective in this application is to develop accurate and reproducible non-invasive CT imaging tools to stratify patients into treatment groups according to stone composition and burden. Based on our extensive preliminary results, our central hypothesis is that dual-energy CT can discriminate several types of renal stones (e.g., uric acid vs. cystine vs. struvite vs. calcium-based stones) and provide accurate quantification of stone burden. Furthermore, we hypothesize that this quantitative assessment of stone composition and burden can be performed using iodine-enhanced dual-energy CT data, which presents an opportunity to reduce patient radiation dose compared to a traditional CT urogram.
Our Specific Aims are:
Aim 1 : Develop a dual-energy CT imaging technique to discriminate between renal stones of different mineral composition.
Aim 2 : Reliably and accurately quantitate stone burden using dual-energy CT.
Aim 3 : Develop a method for stone characterization in the presence of iodinated contrast material. This proposal will develop imaging techniques that allow simultaneous identification of urinary stone type and quantification of stone burden, even in the presence of iodinated contrast material. The significance of this is that these advanced CT imaging techniques will allow physicians to more efficiently direct patient therapy and phenotype research subjects, potentially avoiding procedures associated with higher risk or cost.

Public Health Relevance

Research completed via this Urology O'Brien Center will improve our ability to detect and monitor kidney stones, and increase understanding regarding the factors that make them develop. Studies will also increase understanding of the epidemiology of kidney stones and their ability to cause chronic kidney disease. Results will improve clinical care of patients with nephrolithiasis.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Specialized Center (P50)
Project #
5P50DK083007-05
Application #
8328100
Study Section
Special Emphasis Panel (ZDK1-GRB-6 (O1))
Program Officer
Hoshizaki, Deborah K
Project Start
2008-09-30
Project End
2013-10-31
Budget Start
2012-08-01
Budget End
2013-10-31
Support Year
5
Fiscal Year
2012
Total Cost
$983,060
Indirect Cost
$479,793
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905
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Landry, Greg M; Hirata, Taku; Anderson, Jacob B et al. (2016) Sulfate and thiosulfate inhibit oxalate transport via a dPrestin (Slc26a6)-dependent mechanism in an insect model of calcium oxalate nephrolithiasis. Am J Physiol Renal Physiol 310:F152-9
Haley, William E; Enders, Felicity T; Vaughan, Lisa E et al. (2016) Kidney Function After the First Kidney Stone Event. Mayo Clin Proc 91:1744-1752
Ferrero, Andrea; Montoya, Juan C; Vaughan, Lisa E et al. (2016) Quantitative Prediction of Stone Fragility From Routine Dual Energy CT: Ex vivo proof of Feasibility. Acad Radiol 23:1545-1552
Lieske, John C; Turner, Stephen T; Edeh, Samuel N et al. (2016) Heritability of dietary traits that contribute to nephrolithiasis in a cohort of adult sibships. J Nephrol 29:45-51
Ketha, Hemamalini; Singh, Ravinder J; Grebe, Stefan K et al. (2015) Altered Calcium and Vitamin D Homeostasis in First-Time Calcium Kidney Stone-Formers. PLoS One 10:e0137350
de Cogain, Mitra R; Linnes, Michael P; Lee, Hyo Jung et al. (2015) Aqueous extract of Costus arabicus inhibits calcium oxalate crystal growth and adhesion to renal epithelial cells. Urolithiasis 43:119-24
Lieske, John C; Mehta, Ramila A; Milliner, Dawn S et al. (2015) Kidney stones are common after bariatric surgery. Kidney Int 87:839-45
Qu, Mingliang; Yu, Lifeng; Cardona, Daniel Gomez et al. (2015) Radiation Dose Reduction in Dual-Energy CT: Does It Affect the Accuracy of Urinary Stone Characterization? AJR Am J Roentgenol 205:W172-6
Perinpam, Majuran; Ware, Erin B; Smith, Jennifer A et al. (2015) Effect of Demographics on Excretion of Key Urinary Factors Related to Kidney Stone Risk. Urology 86:690-6

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