The overall objective of this """"""""Center of Excellence in Pediatric Nephrology"""""""" is to provide a coordinated, interdisciplinary, and inter-institutional approach to study the development of the kidney during embryonic, fetal and postnatal life. The main theme of this Research Center is """"""""Kidney Development and Disease: Cell Fate and Precursors of Disease in the Young and Adult."""""""" Broadly, the proposed research deals with fundamental questions of clinical relevance in Pediatric Nephrology such as the understanding of kidney morphogenesis and homeostasis in health and disease. The experimental approaches range from examination of epigenetic mechanisms that control cell fate, plasticity, and identity and the cellular signals underlying the phenotypic transformation that occurs during kidney injury and repair. Project 1 will investigate the role of RBP-J in lineage relationships in the kidney vasculature (Ariel Gomez, UVA). Project 2 will examine the epigenetic mechanisms of nephron progenitor cell renewal and fate (Samir El-Dahr, Tulane). Project 3 will investigate canonical Wnt regulation of renal interstitium fate and function (Jing Yu, UVA). Project 4 will elucidate the cellular mechanisms underlying the formation of atubular glomeruli, a pervasive and under-recognized pathway for nephron loss in a broad spectrum of renal disorders (Robert Chevalier, UVA). Pilot and feasibility projects (PFP) within the general theme of the program will be solicited from the Universities at large and the ASPN with the objective to add new talent to the investigation of renal diseases in children. Examples of PFPs include: Pilot 1 addresses the role of p53-mediated regulation of Wnt/pcatenin signaling in nascent nephron formation (Zubaida Saifudeen, Tulane), Pilot 2 addresses the role of Jagged 1 in kidney vascular development (Brian Belyea, UVA). The Center will be supported by an Administrative Core which will allocate and distribute resources to Center participants, implement the procedures for soliciting and selecting candidates for the PFP, maintain a Center website and an Enrichment/Educational program to provide resources for the support of research students, the development of repository data, workshops, seminars and symposia to enhance research in kidney development and disease. This Pediatric Center of Excellence in Nephrology has the necessary expertise, manpower, focus, commitment, and institutional support to accomplish the proposed goals. It is anticipated that the Center of Excellence will lead to improved management of infants and children with renal and urological diseases.

Public Health Relevance

The advances in knowledge obtained through the research and scientific exchange fostered by this Center of Excellence in Pediatric Nephrology will add to the scientific understanding that will lead to improved management of infants and children with renal and urological diseases.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1-GRB-G (M3))
Program Officer
Moxey-Mims, Marva M
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Virginia
Schools of Medicine
United States
Zip Code
Lu, Ko-Ting; Keen, Henry L; Weatherford, Eric T et al. (2016) Estrogen Receptor α Is Required for Maintaining Baseline Renin Expression. Hypertension 67:992-9
Hilliard, Sylvia A; El-Dahr, Samir S (2016) Epigenetics mechanisms in renal development. Pediatr Nephrol 31:1055-60
Shinohara, Keisuke; Liu, Xuebo; Morgan, Donald A et al. (2016) Selective Deletion of the Brain-Specific Isoform of Renin Causes Neurogenic Hypertension. Hypertension 68:1385-1392
Forbes, M S; Thornhill, B A; Galarreta, C I et al. (2016) A population of mitochondrion-rich cells in the pars recta of mouse kidney. Cell Tissue Res 363:791-803
Gomez, R Ariel; Sequeira-Lopez, Maria Luisa S (2016) Novel Functions of Renin Precursors in Homeostasis and Disease. Physiology (Bethesda) 31:25-33
Hu, Yan; Li, Minghong; Göthert, Joachim R et al. (2016) Hemovascular Progenitors in the Kidney Require Sphingosine-1-Phosphate Receptor 1 for Vascular Development. J Am Soc Nephrol 27:1984-95
Belyea, Brian C; Xu, Fang; Sequeira-Lopez, Maria Luisa S et al. (2015) Loss of Jagged1 in renin progenitors leads to focal kidney fibrosis. Physiol Rep 3:
Chevalier, Robert L (2015) Congenital urinary tract obstruction: the long view. Adv Chronic Kidney Dis 22:312-9
Lin, Eugene E; Pentz, Ellen S; Sequeira-Lopez, Maria Luisa S et al. (2015) Aldo-keto reductase 1b7, a novel marker for renin cells, is regulated by cyclic AMP signaling. Am J Physiol Regul Integr Comp Physiol 309:R576-84
Sergio, Maria; Galarreta, Carolina I; Thornhill, Barbara A et al. (2015) The Fate of Nephrons in Congenital Obstructive Nephropathy: Adult Recovery is Limited by Nephron Number Despite Early Release of Obstruction. J Urol 194:1463-72

Showing the most recent 10 out of 24 publications