The fundamental goal of the Pediatric Center of Excellence in Nephrology at Cincinnati Children's Hospital Medical Center (CCHMC PCEN) is to support basic, translational, and clinical research, focused on three identified critical pediatric kidney diseases that have major unmet needs. Major components of this goal include to attract outstanding scientific expertise to the study of these focus areas in a multidisciplinary manner, to provide high-resource Cores to support research that utilizes technologies in a timely and efficient manner, and to support novel exploratory pilot projects from promising individuals that represent the future generations of leaders in the focus areas. The primary goal of the Administrative Core is to ensure that the CCHMC PCEN Center functions as a well-coordinated and highly integrated interdisciplinary research platform that synergizes with each Center member's investigation into the three identified critical pediatric kidney disease focus areas. This will be accomplished by organizing interdisciplinary scientific exchanges, providing support in key administrative and secretarial areas, providing web-based communications and information technology, and by administering the Pilot and Feasibility Program and the Enrichment Program. Thus, the Administrative Core will oversee all functions of the CCHMC PCEN Center, including membership, core services, enrichment program, pilot and feasibility program, monitoring scientific output, financial supervision, and budget management The Specific Aims of the Administrative Core are; ? Aim 1. To provide leadership and set the agenda for the research goals of the Center ? Aim 2. To provide administrative, clerical, finance and budget management support to Center members ? Aim 3. To provide biostatistical, bioinformatics, and information technology support to Center members ? Aim 4. To organize an Internal Advisory Board and an External Advisory Board ? Aim 5. To organize and implement the Pilot/Feasibility and Enrichment Programs

Public Health Relevance

Pediatric kidney diseases due to acute kidney injury, focal segmental glomerulosclerosis, and lupus nephritis contribute to an enormous major impact on the U.S. public health and a major financial burden. The Administrative Core of this Center of Excellence in Nephrology will bring together experts from multiple facets of science to focus their energies on these three disease states to change their dismal outcomes.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Specialized Center (P50)
Project #
5P50DK096418-02
Application #
8548110
Study Section
Special Emphasis Panel (ZDK1-GRB-G)
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
2
Fiscal Year
2013
Total Cost
$260,451
Indirect Cost
$90,222
Name
Cincinnati Children's Hospital Medical Center
Department
Type
DUNS #
071284913
City
Cincinnati
State
OH
Country
United States
Zip Code
45229
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Haase-Fielitz, Anja; Haase, Michael; Devarajan, Prasad (2014) Neutrophil gelatinase-associated lipocalin as a biomarker of acute kidney injury: a critical evaluation of current status. Ann Clin Biochem 51:335-51
Wang, Zhu; Ma, Shuangge; Zappitelli, Michael et al. (2014) Penalized count data regression with application to hospital stay after pediatric cardiac surgery. Stat Methods Med Res :
Jotwani, Vasantha; Scherzer, Rebecca; Abraham, Alison et al. (2014) Does HIV infection promote early kidney injury in women? Antivir Ther 19:79-87
Lennon, Michael; Devarajan, Prasad (2014) In memoriam of Clark Darwin West, MD July 4, 1918-January 11, 2014. Pediatr Nephrol 29:1293-4
Devarajan, Prasad (2014) NGAL for the detection of acute kidney injury in the emergency room. Biomark Med 8:217-9
Riley, Alyssa A; Jefferies, John L; Nelson, David P et al. (2014) Peritoneal dialysis does not adversely affect kidney function recovery after congenital heart surgery. Int J Artif Organs 37:39-47
Peralta, Ca; Scherzer, R; Grunfeld, C et al. (2014) Urinary biomarkers of kidney injury are associated with all-cause mortality in the Women's Interagency HIV Study (WIHS). HIV Med 15:291-300
Devarajan, Prasad (2013) Pediatric Acute Kidney Injury: Different From Acute Renal Failure But How And Why. Curr Pediatr Rep 1:34-40
Bagshaw, Sean M; Bennett, Michael; Devarajan, Prasad et al. (2013) Urine biochemistry in septic and non-septic acute kidney injury: a prospective observational study. J Crit Care 28:371-8

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