In response to RFA-DK-11-009, our overall goal is to create a Pediatric Center of Excellence in Nephrology at Cincinnati Children's Hospital Medical Center (CCHMC PGEN), to support basic, translational, and clinical research on critical pediatric kidney diseases that have major unmet needs. The overarching theme is to conduct innovative and high-impact bench-to-bedside studies on three critical but underserved pediatric kidney diseases. Our three areas of focus include acute kidney injury, focal segmental glomerulosclerosis, and lupus nephritis, already developed as areas of multidisciplinary expertise at our institution. The urgent need will be addressed by three individual research projects as well as by the three Biomedical Cores, all proposed by outstanding funded investigators with a track record of successful multidisciplinary collaborative efforts in the focu areas. The two novel exploratory pilot studies proposed by exceptional and promising young investigators will form the basis for their future investigator-initiated applications to study acue kidney injury.
The specific aims i nclude: (1) to attract outstanding scientific expertise into the study of critical but underserved pediatric kidney diseases;(2) to foster multidisciplinary approaches to the study of critical but underserved pediatric kidney diseases within our focus areas at the basic, translational, and clinical levels;(3) To provide high-resource Gene Expression, Proteomics, and Biomarker Cores to support the study of pediatric kidney diseases locally, regionally, and nationally;and (4) to support novel exploratory pilot studies that will form the basis for future investigator-initiated applications t study critical but underserved pediatric kidney diseases. Evidence for strong support from institutional leadership is provided. Added strengths include the CCHMC Pediatric Nephrology Division, with a proven track record of excellence and collaboration in the study of the three focus areas. Active support and collaboration from the institutional CTSA and from a large number of divisions that are involved in multidisciplinary collaborative efforts in the three focus areas of study provide the extended resources for success. The proposal also comes with active support and collaboration from our NIH funded T32 Fellowship Training Program.

Public Health Relevance

Pediatric kidney diseases due to acute kidney injury, focal segmental glomerulosclerosis, and lupus nephritis contribute to an enormous major impact on the U.S. public health and a major financial burden. The Pediatric Center of Excellence in Nephrology at CCHMC will bring together experts from multiple facets of science and medicine to focus their energies on these three disease states to change their dismal outcomes.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Specialized Center (P50)
Project #
3P50DK096418-02S2
Application #
8820663
Study Section
Special Emphasis Panel (ZDK1-GRB-G (M3))
Program Officer
Moxey-Mims, Marva M
Project Start
2012-09-21
Project End
2017-08-31
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
2
Fiscal Year
2014
Total Cost
$100,000
Indirect Cost
$35,898
Name
Cincinnati Children's Hospital Medical Center
Department
Type
DUNS #
071284913
City
Cincinnati
State
OH
Country
United States
Zip Code
45229
Magella, Bliss; Adam, Mike; Potter, Andrew S et al. (2018) Cross-platform single cell analysis of kidney development shows stromal cells express Gdnf. Dev Biol 434:36-47
Lang, Joshua; Katz, Ronit; Ix, Joachim H et al. (2018) Association of serum albumin levels with kidney function decline and incident chronic kidney disease in elders. Nephrol Dial Transplant 33:986-992
Chihanga, Tafadzwa; Ma, Qing; Nicholson, Jenna D et al. (2018) NMR spectroscopy and electron microscopy identification of metabolic and ultrastructural changes to the kidney following ischemia-reperfusion injury. Am J Physiol Renal Physiol 314:F154-F166
Greenberg, Jason H; Zappitelli, Michael; Jia, Yaqi et al. (2018) Biomarkers of AKI Progression after Pediatric Cardiac Surgery. J Am Soc Nephrol 29:1549-1556
Volovelsky, Oded; Gist, Katja M; Terrell, Tara C et al. (2018) Early postoperative measurement of fibroblast growth factor 23 predicts severe acute kidney injury in infants after cardiac surgery?. Clin Nephrol 90:165-171
Gist, Katja M; Cooper, David S; Wrona, Julia et al. (2018) Acute Kidney Injury Biomarkers Predict an Increase in Serum Milrinone Concentration Earlier Than Serum Creatinine-Defined Acute Kidney Injury in Infants After Cardiac Surgery. Ther Drug Monit 40:186-194
Bennett, Michael R; Pyles, Olivia; Ma, Qing et al. (2018) Preoperative levels of urinary uromodulin predict acute kidney injury after pediatric cardiopulmonary bypass surgery. Pediatr Nephrol 33:521-526
Albert, Christian; Albert, Annemarie; Bellomo, Rinaldo et al. (2018) Urinary neutrophil gelatinase-associated lipocalin-guided risk assessment for major adverse kidney events after open-heart surgery. Biomark Med 12:975-985
Basu, Rajit K; Kaddourah, Ahmad; Goldstein, Stuart L et al. (2018) Assessment of a renal angina index for prediction of severe acute kidney injury in critically ill children: a multicentre, multinational, prospective observational study. Lancet Child Adolesc Health 2:112-120
Jotwani, Vasantha; Scherzer, Rebecca; Glidden, David V et al. (2018) Pre-exposure Prophylaxis With Tenofovir Disoproxil Fumarate/Emtricitabine and Kidney Tubular Dysfunction in HIV-Uninfected Individuals. J Acquir Immune Defic Syndr 78:169-174

Showing the most recent 10 out of 124 publications