In response to RFA-DK-11-009, our overall goal is to create a Pediatric Center of Excellence in Nephrology at Cincinnati Children's Hospital Medical Center (CCHMC PGEN), to support basic, translational, and clinical research on critical pediatric kidney diseases that have major unmet needs. The overarching theme is to conduct innovative and high-impact bench-to-bedside studies on three critical but underserved pediatric kidney diseases. Our three areas of focus include acute kidney injury, focal segmental glomerulosclerosis, and lupus nephritis, already developed as areas of multidisciplinary expertise at our institution. The urgent need will be addressed by three individual research projects as well as by the three Biomedical Cores, all proposed by outstanding funded investigators with a track record of successful multidisciplinary collaborative efforts in the focu areas. The two novel exploratory pilot studies proposed by exceptional and promising young investigators will form the basis for their future investigator-initiated applications to study acue kidney injury.
The specific aims i nclude: (1) to attract outstanding scientific expertise into the study of critical but underserved pediatric kidney diseases;(2) to foster multidisciplinary approaches to the study of critical but underserved pediatric kidney diseases within our focus areas at the basic, translational, and clinical levels;(3) To provide high-resource Gene Expression, Proteomics, and Biomarker Cores to support the study of pediatric kidney diseases locally, regionally, and nationally;and (4) to support novel exploratory pilot studies that will form the basis for future investigator-initiated applications t study critical but underserved pediatric kidney diseases. Evidence for strong support from institutional leadership is provided. Added strengths include the CCHMC Pediatric Nephrology Division, with a proven track record of excellence and collaboration in the study of the three focus areas. Active support and collaboration from the institutional CTSA and from a large number of divisions that are involved in multidisciplinary collaborative efforts in the three focus areas of study provide the extended resources for success. The proposal also comes with active support and collaboration from our NIH funded T32 Fellowship Training Program.

Public Health Relevance

Pediatric kidney diseases due to acute kidney injury, focal segmental glomerulosclerosis, and lupus nephritis contribute to an enormous major impact on the U.S. public health and a major financial burden. The Pediatric Center of Excellence in Nephrology at CCHMC will bring together experts from multiple facets of science and medicine to focus their energies on these three disease states to change their dismal outcomes.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Specialized Center (P50)
Project #
5P50DK096418-03
Application #
8731215
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Moxey-Mims, Marva M
Project Start
2012-09-21
Project End
2017-08-31
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
3
Fiscal Year
2014
Total Cost
Indirect Cost
City
Cincinnati
State
OH
Country
United States
Zip Code
45229
Nehus, Edward; Kaddourah, Ahmad; Bennett, Michael et al. (2017) Subclinical Kidney Injury in Children Receiving Nonsteroidal Anti-Inflammatory Drugs After Cardiac Surgery. J Pediatr 189:175-180
Varnell Jr, Charles D; Goldstein, Stuart L; Devarajan, Prasad et al. (2017) Impact of Near Real-Time Urine Neutrophil Gelatinase-Associated Lipocalin Assessment on Clinical Practice. Kidney Int Rep 2:1243-1249
Bennett, Michael R; Pleasant, LaTawnya; Haffner, Christopher et al. (2017) A Novel Biomarker Panel to Identify Steroid Resistance in Childhood Idiopathic Nephrotic Syndrome. Biomark Insights 12:1177271917695832
Turnier, Jessica L; Fall, Ndate; Thornton, Sherry et al. (2017) Urine S100 proteins as potential biomarkers of lupus nephritis activity. Arthritis Res Ther 19:242
Garimella, Pranav S; Jaber, Bertrand L; Tighiouart, Hocine et al. (2017) Association of Preoperative Urinary Uromodulin with AKI after Cardiac Surgery. Clin J Am Soc Nephrol 12:10-18
Garimella, Pranav S; Bartz, Traci M; Ix, Joachim H et al. (2017) Urinary Uromodulin and Risk of Urinary Tract Infections: The Cardiovascular Health Study. Am J Kidney Dis 69:744-751
Gulati, G; Bennett, M R; Abulaban, K et al. (2017) Prospective validation of a novel renal activity index of lupus nephritis. Lupus 26:927-936
Devarajan, Prasad; Basu, Rajit K (2017) Sepsis-associated acute kidney injury - is it possible to move the needle against this syndrome? J Pediatr (Rio J) 93:1-3
Kamal, Fadia A; Travers, Joshua G; Schafer, Allison E et al. (2017) G Protein-Coupled Receptor-G-Protein ??-Subunit Signaling Mediates Renal Dysfunction and Fibrosis in Heart Failure. J Am Soc Nephrol 28:197-208
Pleasant, LaTawnya; Ma, Qing; Devarajan, Mahima et al. (2017) Increased susceptibility to structural acute kidney injury in a mouse model of presymptomatic cardiomyopathy. Am J Physiol Renal Physiol 313:F699-F705

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